Results 71 to 80 of about 19,218 (261)

Signaling Pathways and Therapeutic Strategies in Advanced Basal Cell Carcinoma [PDF]

, 2023
Non-melanoma skin cancers (NMSCs) are the most common human neoplasms world-wide. In detail, basal cell carcinoma (BCC) is the most frequent malignancy in the fair-skinned population.
Linda Tognetti, Gentileschi, Stefano, Costanza Canino, Pietro Rubegni, Trovato, Emanuele, Giulia Vallini, Stefano Gentileschi, Rubegni, Pietro, Emanuele Trovato, Tognetti, Linda, Vallini, Giulia, Canino, Costanza, Calabrese, Laura, Laura Calabrese   +13 more
core   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source

The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets

Life Science Alliance, 2021
Basal cell carcinoma (BCC) is the most common skin cancer and human malignancy. By analyzing BCC RNA sequencing data according to clinically important features, we identified novel differentially regulated genes and new targetable pathways.
Ivan V Litvinov, Pingxing Xie, Scott Gunn, Denis Sasseville, Philippe Lefrançois   +4 more
doaj   +1 more source

Supplementary Data from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma

, 2022
Supplementary Data from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell ...
Nicole Basset-Seguin (187601), Florian Herms (15045215), Nicolas Meyer (86532), Caroline Dutriaux (15033126), Andrey A. Yurchenko (15045188), Fanny Bouquet (15045206), Brigitte Dreno (292705), Fatemeh Rajabi (691876), Sergey I. Nikolaev (14909870), Florent Grange (3569189), Caroline Robert (15032672), Lukas Flatz (251190), Meriem Ighilahriz (15045194), Oltin T. Pop (15045191), Samia Mourah (15033147), Sandrine Monestier (15045212), Nicolas Dumaz (365666), Frederic J. de Sauvage (15045218), Nicolas Poulalhon (15045200), Andrej Besse (2899043), Jerome Lambert (282171), Marc Delord (12064068), Antonio Alberti (15045203), Ariel Savina (3157380), Philippe Saiag (4219240), Max Mendez-Lopez (15045209), Nadem Soufir (108407), Maxime Battistella (15033144), Hayley J. Sharpe (15045197), Ismael Padioleau (687518), Laurent Mortier (4030046), Amir Khammari (149729)   +31 more
core   +1 more source

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

Basal cell carcinoma.

, 2022
Representative treatment patterns among randomly selected patients treated within the first 90 days with vismodegib (n = 40, A), non-vismodegib treatment (n = 40, B), and observation (n = 28, C).
Simon Yoo (11949194), Aleksandar Sekulic (3192720), Laura Chu (1891477), Edward McKenna (4030052), Yong Mun (9200749), Julie Guillen (11949200), Ragini Kudchadkar (11949197), Gary Rogers (505210), Keith Dawson (11949209), Scott Guenthner (11949203), Mario Lacouture (11949212), Anne Lynn S. Chang (3339900), Bernard Raskin (11949206)   +12 more
core   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Complete response with combined sonidegib and pembrolizumab in synchronous advanced basal cell carcinoma and metastatic cutaneous squamous cell carcinoma: A case report

EJC Skin Cancer
Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the most common skin cancers. While most cases are managed with local therapies, advanced disease may require systemic treatment.
Paola Valeria Marchese, Carolina Ortiz, Julia Lostes Bardaji, Francesca Comito, Eva Muñoz-Couselo   +4 more
doaj   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source