Results 81 to 90 of about 8,380,026 (270)

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

OPTICAL COHERENCE TOMOGRAPHY EVALUATION IN LOCALLY ADVANCED BASAL CELL CARCINOMA DURING SYSTEMIC TREATMENT

, 2023
Background: Basal cell carcinoma (BCC) is the most common cancer in the Caucasian population, and in Italy its incidence is around 100 cases per 100,000 population. It has a multifactorial pathogenesis, and the most important environmental risk factor is
Cantisani Carmen, Rovaldi Emanuele, Pellacani Giovanni, Ambrosio Luca, Azzella Giulia, Rega Federica, Rossi Giovanni, Paolino Giovanni, Di Guardo Antonio, Noah M.   +9 more
core  

Supplementary Data from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma

, 2022
Supplementary Data from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell ...
Nicole Basset-Seguin (187601), Florian Herms (15045215), Nicolas Meyer (86532), Caroline Dutriaux (15033126), Andrey A. Yurchenko (15045188), Fanny Bouquet (15045206), Brigitte Dreno (292705), Fatemeh Rajabi (691876), Sergey I. Nikolaev (14909870), Florent Grange (3569189), Caroline Robert (15032672), Lukas Flatz (251190), Meriem Ighilahriz (15045194), Oltin T. Pop (15045191), Samia Mourah (15033147), Sandrine Monestier (15045212), Nicolas Dumaz (365666), Frederic J. de Sauvage (15045218), Nicolas Poulalhon (15045200), Andrej Besse (2899043), Jerome Lambert (282171), Marc Delord (12064068), Antonio Alberti (15045203), Ariel Savina (3157380), Philippe Saiag (4219240), Max Mendez-Lopez (15045209), Nadem Soufir (108407), Maxime Battistella (15033144), Hayley J. Sharpe (15045197), Ismael Padioleau (687518), Laurent Mortier (4030046), Amir Khammari (149729)   +31 more
core   +1 more source

m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6‐Mediated Wnt/β‐catenin Signaling Pathway

Advanced Science, EarlyView.
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao, Jian Zhang, Qi Qian, Min Jiang, Yu Liu, Yan Geng, Nan Cui, Qi Guo, Jie Guo   +8 more
wiley   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

Sonidegib: Safety and Efficacy in Treatment of Advanced Basal Cell Carcinoma

Dermatology and Therapy, 2020
Hedgehog inhibitors are promising alternative treatments for patients with advanced basal cell carcinomas. Sonidegib (Odomzo®), an oral smoothened (SMO) antagonist, is indicated for the treatment of adult patients with locally advanced basal cell ...
Alessia Villani, Gabriella Fabbrocini, Claudia Costa, Massimiliano Scalvenzi   +3 more
doaj   +1 more source

Desempenho dos marcadores EGFR, CK5, CK14, p63 e P-caderina para identificar o fenótipo basal do carcinoma de mama [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências MédicasOs estudos dos perfis de expressão gênica dos carcinomas de mama identificaram um subtipo de tumor com pior ...
Vieira, Daniella Serafin Couto
core  

Basal cell carcinoma.

, 2022
Representative treatment patterns among randomly selected patients treated within the first 90 days with vismodegib (n = 40, A), non-vismodegib treatment (n = 40, B), and observation (n = 28, C).
Simon Yoo (11949194), Aleksandar Sekulic (3192720), Laura Chu (1891477), Edward McKenna (4030052), Yong Mun (9200749), Julie Guillen (11949200), Ragini Kudchadkar (11949197), Gary Rogers (505210), Keith Dawson (11949209), Scott Guenthner (11949203), Mario Lacouture (11949212), Anne Lynn S. Chang (3339900), Bernard Raskin (11949206)   +12 more
core   +1 more source

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

Advanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang   +10 more
wiley   +1 more source