Results 61 to 70 of about 19,218 (261)

Vismodegib: A smoothened inhibitor for the treatment of advanced basal cell carcinoma

Indian Dermatology Online Journal, 2013
Incidence of basal cell carcinoma (BCC), the most common skin cancer in humans, is rising. Surgery is the mainstay of treatment but there is no standard of care for locally advanced or metastatic disease. Hedgehog signaling proteins are critical for cell
Suruchi Aditya, Aditya Rattan
doaj   +1 more source

Sonidegib en el tratamiento del carcinoma basocelular localmente avanzado

Actas Dermo-Sifiliográficas, 2021
Resumen: Sonidegib es un inhibidor del receptor transmembrana Smoothened (SMO), de la vía de señalización de Hedgehog, indicado para el tratamiento del carcinoma basocelular localmente avanzado (CBCla), no susceptible a cirugía curativa ni a radioterapia.
O. Sanmartín, B. Llombart, G. Carretero Hernández, Á. Flórez Menéndez, R. Botella-Estrada, E. Herrera Ceballos, S. Puig   +6 more
doaj   +1 more source

OPTICAL COHERENCE TOMOGRAPHY EVALUATION IN LOCALLY ADVANCED BASAL CELL CARCINOMA DURING SYSTEMIC TREATMENT

, 2023
Background: Basal cell carcinoma (BCC) is the most common cancer in the Caucasian population, and in Italy its incidence is around 100 cases per 100,000 population. It has a multifactorial pathogenesis, and the most important environmental risk factor is
Cantisani Carmen, Rovaldi Emanuele, Pellacani Giovanni, Ambrosio Luca, Azzella Giulia, Rega Federica, Rossi Giovanni, Paolino Giovanni, Di Guardo Antonio, Noah M.   +9 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Maxillary plexiform ameloblastoma showing basaloid differentiation: Report of a rare case with review of literature

Indian Journal of Dental Research, 2015
Ameloblastoma is a benign, locally aggressive tumor originating from the odontogenic epithelium. It manifests as a slow growing swelling, causing expansion of the jaw bones.
Sravani Ghattamaneni, Venkateswara Rao Guttikonda, M Geetha Kumari, D Rakesh Kumar   +3 more
doaj   +1 more source

Attitudes among dermatologists regarding non-melanoma skin cancer treatment options

Discover Oncology, 2021
Non-melanoma skin cancers include basal and squamous cell carcinoma. These tumors have become an important health issue for their high incidence and for the morbidity, especially if untreated for a long period.
Luca Fania, Tonia Samela, Gaia Moretta, Francesco Ricci, Elena Dellambra, Mara Mancini, Francesca Sampogna, Annarita Panebianco, Damiano Abeni   +8 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hedgehog Pathway Inhibition for the Treatment of Basal Cell Carcinoma

, 2019
Globally, basal cell carcinoma is the most commonly diagnosed cancer. While most cases are amenable to surgery, treatment options for advanced basal cell carcinoma, including locally advanced basal cell carcinoma and metastatic basal cell carcinoma, have
Gutzmer, Ralf, Solomon, James A.
core   +1 more source

Reflectance Confocal Microscopy Identification of Subclinical Basal Cell Carcinoma after Vismodegib Treatment: Report of a Case

, 2021
Although surgery represents the treatment of choice for the majority of basal cell carcinomas, different therapies are required to treat the advanced ones.
Fabbrocini G., Villani A., Scalvenzi M., Costa C.   +3 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source