Results 241 to 250 of about 75,890 (310)

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Efficacy of irreversible electroporation combined with immunotherapy versus irreversible electroporation alone in locally advanced pancreatic cancer: a propensity score-matched retrospective study. [PDF]

Front Immunol
Xi P, Sun P, Chen M, Yao Z, Zhu Q, Li S, He C.   +6 more
europepmc   +1 more source

Immunotherapy and Breast Reconstruction: Opportunities, Challenges, and Future Directions

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Immunotherapy is transforming breast cancer management, but it also presents new challenges for surgical and reconstructive practice. This review summarizes current evidence on immune checkpoint inhibitors, perioperative safety, and immune‐related adverse events, highlighting their impact on surgical timing, postoperative recovery, and ...
Shuang Li, Jianguo Wang, Yingjie Liu, Wenwu Cai, Weichang Zhang, Shengyun Li, Yunjian Zhang   +6 more
wiley   +1 more source

Progression-free survival for unresectable non-metastatic locally advanced pancreatic cancer after surgical microwave ablation plus durvalumab and tremelimumab: phase-2 non-randomized prospective clinical trial. [PDF]

Commun Med (Lond)
Topal H, Venken T, Bassez A, Chiritescu G, Van Cutsem E, van der Merwe S, Lambrechts D, Topal B.   +7 more
europepmc   +1 more source

Multi‐Transcriptomic Analysis Reveals That EREG‐Driven TME Crosstalk Defines Anti‐EGFR Response in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 5, May 2026.
A multi‐transcriptomic analysis reveals the “EREG/EGFR/CSF axis” as a key intercellular network in the tumor microenvironment that dictates anti‐EGFR sensitivity in colorectal cancer. ABSTRACT Sidedness influences colorectal cancer (CRC) prognosis and treatment response, yet the mechanism dictating differential EGFR inhibitor (EGFRI) sensitivity is ...
Atsuki Taniguchi, Shunsuke Kagawa, Shohei Nogi, Tomohiko Yagi, Nobuhiko Kanaya, Shinji Kuroda, Satoru Kikuchi, Yoshihiko Kakiuchi, Hiroshi Tazawa, Toshiyoshi Fujiwara   +9 more
wiley   +1 more source

Modern Clinical Trials: Seamless Designs and Master Protocols

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Drug development is often inefficient, costly and lengthy, yet it is essential for evaluating the safety and efficacy of new interventions. Compared with other disease areas, this is particularly true for Phase II/III cancer clinical trials where many drug candidates fail to advance and reduced regulatory approvals are being seen ...
Abigail Burdon, Thomas Jaki, Xijin Chen, Pavel Mozgunov, Haiyan Zheng, Richard Baird   +5 more
wiley   +1 more source

Prognostic model for resected borderline and locally advanced pancreatic cancer after neoadjuvant chemotherapy. [PDF]

Int J Surg
Son J, Lee W, Lee JB, Hong K, Sung MK, Park Y, Jun E, Song KB, Hwang DW, Lee JH, Kim SC.   +10 more
europepmc   +1 more source

Predicting Prognosis for Gastric Cancer Patients Receiving Neoadjuvant Treatment With Body Composition‐Based Deep Learning

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background This study sought to develop an innovative body composition (BC)‐based deep learning (DL) model to precisely evaluate survival in gastric cancer (GC) patients undergoing neoadjuvant treatment (NT). Materials and Methods This retrospective study included GC patients undergoing NT from two centers.
Yingjing Zhang, Tong Tong, Bowen Hou, Tian Yu, Pengfei Su, Jianchun Yu, Yakai Huang   +6 more
wiley   +1 more source

Nationwide implementation of the international multidisciplinary best-practice for locally advanced pancreatic cancer (PREOPANC-4): study protocol. [PDF]

BMC Cancer
Stoop TF, Seelen LWF, van 't Land FR, van der Hout AC, Scheepens JCM, Ali M, Stiggelbout AM, van der Kolk BM, Bonsing BA, Lips DJ, de Groot DJA, van Veldhuisen E, Kerver ED, Manusama ER, Daams F, Kazemier G, Cirkel GA, van Tienhoven G, Patijn GA, Lelieveld-Rier HN, de Hingh IH, van Hellemond IEG, Wijsman JH, Erdmann JI, Mieog JSD, de Vos-Geelen J, de Groot JWB, Lutchman KRD, Mekenkamp LJ, Kranenburg LW, Beuk LPM, Nijkamp MW, den Dulk M, Polée MB, Homs MYV, Wumkes ML, Stommel MWJ, Busch OR, de Wilde RF, Theijse RT, Luelmo SAC, Festen S, Bollen TL, Neumann UP, de Meijer VE, Draaisma WA, Groot Koerkamp B, Molenaar IQ, Wolfgang CL, Del Chiaro M, Katz MGH, Hackert T, Rietjens JAC, Wilmink JW, van Santvoort HC, van Eijck CHJ, Besselink MG, Dutch Pancreatic Cancer Group.   +57 more
europepmc   +1 more source

Contrasting Ocular Manifestations of Xeroderma Pigmentosum in Siblings

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Xeroderma Pigmentosum (XP) can present with markedly different ocular severities even among siblings sharing the same genetic background. Early detection and preventive care are crucial to reduce the risk of vision‐ and life‐threatening malignancies.
Mohammad Taher Rajabi, Ali Asadzadeh, Seyed Mohsen Rafizadeh, Amirhossein Aghajani, Amin Zand   +4 more
wiley   +1 more source