Results 151 to 160 of about 1,652,717 (354)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Traveling Wave Fault Location for AC Transmission Lines: An Approach Based on the Application of EMD and Teager Energy Operator [PDF]

open access: green
Andressa Pereira Oliveira   +3 more
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Ethical and Political Responsibility in Location Based Services - The Need of Implementing Ethical Thinking in Our Research Field [PDF]

open access: yes, 2014
Rapid technical developments in Location Based Services (LBS) lead to new applications and possibilities in many personal and institutional sectors. LBS became a powerful instrument in predicting consumer behaviour and preventing crime.
Retscher, Günther, Obex, Franz
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Barriers seen by potential local providers of applications using location-based services [PDF]

open access: yes, 2019
This contribution focuses on obstacles in the adoption of location-based services (LBS) as a tool for potential providers of localised applications and content. The following key question needs to be answered: What are the key factors preventing LBS from
Neuper, Oliver,   +6 more
core  

Design and Implementation of Internet Protocol Based Geolocation System

open access: yesJournal of Engineering and Sustainable Development, 2013
Determining the geographic location of an Internet Protocol (IP) devices based on its IP addresses is a challenging matter because of wide network topologies and many protocols used to interconnect these devices. On the other hand, the Internet Protocol
Muayad Khalil Murtadha
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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