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Effects of MPTP on locomotor activity in mice

Neurotoxicology and Teratology, 1990
Thirty-two mice were randomly assigned to one of 4 groups of 8 animals each: the first received IP saline injections and the other 3 groups received 10, 20 or 30 mg/kg MPTP. Each dose or saline was administered 3 times in 3 consecutive days and locomotor activity was measured during the next 3 days. In addition, the animals were observed in 2 trials in
V A, Colotla   +4 more
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Cocaine-induced locomotor activity in rats

Pharmacology Biochemistry and Behavior, 1991
Rats were injected SC or IP with a dose of cocaine at 20 mg/kg twice daily or saline (2 ml/kg) for 15 consecutive doses. Horizontal (including ambulatory and repetitive activity) and ambulatory locomotor activities were assessed following the first (acute) and the 15th (chronic) injections. Total locomotor activity (area under curve, AUC) following the
S Y, Yeh, C A, Haertzen
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Neuropharmacology of light-induced locomotor activation

Neuropharmacology, 2015
Presentation of non-aversive light stimuli for several seconds was found to reliably induce locomotor activation and exploratory-like activity. Light-induced locomotor activity (LIA) can be considered a convenient simple model to study sensory-motor activation.
Davide, Amato   +7 more
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Hyperuricemia and locomotor activity in developing rats

Pharmacology Biochemistry and Behavior, 1989
This research was motivated by the previous finding that serum uric acid levels correlate with symptoms of hyperactivity in normal children. We attempted, therefore, to investigate this relationship in an animal model. Dose and time relationships between allantoxanamide-induced heightened serum uric acid and locomotor activity were investigated. A dose-
C M, Barrera, R E, Hunter, W P, Dunlap
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Effects of U50,488H on locomotor activity in the hamster

Pharmacology Biochemistry and Behavior, 1990
Two experiments investigated the effects of the specific kappa opiate agonist, U50,488 on locomotor activity in the golden Syrian hamster. In Experiment 1, the effects of U50,488 were found to be dose-related, with a 1 mg/kg dose eliciting hyperactivity and a 10 mg/kg dose eliciting hypoactivity.
P, Schnur, J M, Walker
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Locomotor activity and exploration

1993
Publisher Summary This chapter provides an overview of locomotor activity and exploration. The analysis of the drug effects on general motor activity and exploratory behavior has been central to the field of behavioral pharmacology since its inception.
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Trunk Kinematics During Locomotor Activities

Physical Therapy, 1992
We investigated upper-body (ie, trunk) angular kinematics (motions) during gait, stair climbing and descending, and rising from a chair in two reference frames--relative to the pelvis and to room coordinates. Bilateral kinematic data were collected from 11 healthy subjects (6 female, 5 male), who were 27 to 88 years of age (mean = 58.9, SD = 17.9 ...
D E, Krebs   +4 more
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The effect of clonidine on locomotor activity in mice

Life Sciences, 1972
Abstract Clonidine decreased the locomotor activity in mice despite marked sympathomimetic signs. It did not stimulate locomotor activity depressed by pretreatment with reserpine, alpha-methyltyrosine, FLA-63, spiroperidol or phenoxybenzamine. The combined apomorphine-clonidine treatment increased the motor activity in normal, reserpine-, alpha ...
J, Maj   +3 more
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Analysis of locomotor activity rhythms in Drosophila

Nature Protocols, 2006
The genetic, molecular and anatomical dissection of the circadian clock in Drosophila and other higher organisms relies on the quantification of rhythmic phenotypes. Here, we introduce the methods currently in use in our laboratories for the analysis of fly locomotor activity rhythms.
Rosato, E, Kyriacou, CP
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Circadian Rhythms of Locomotor Activity in Zebrafish

Physiology & Behavior, 1998
As part of an effort to characterize the circadian system of the zebrafish, we examined the circadian regulation of locomotor activity in adult males and females. Gross locomotor activity was measured using infrared movement detectors. The effects of light, dark, and temperature on the amplitude, phase, and free-running periods of locomotor rhythms ...
M W, Hurd   +3 more
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