Results 41 to 50 of about 1,004,933 (340)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Frege's logicism [PDF]

open access: yes, 2016
In this paper, I provide an interpretation of Frege's logicist project, drawing a connection between it and his idiosyncratic view of ...
Henderson, Jared
core   +1 more source

Translation of Tanabe Hajime’s “The Limit of Logicism in Epistemology: A Critique of the Marburg and Freiburg Schools”

open access: yesJournal of World Philosophies, 2017
This article provides the first English translation of Tanabe’s early essay, “The Limit of Logicism in Epistemology: A Critique of the Marburg and Freiburg Schools” (1914).
Takeshi Morisato
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Logicism, Ontology, and the Epistemology of Second-Order Logic [PDF]

open access: yes, 2018
In two recent papers, Bob Hale has attempted to free second-order logic of the 'staggering existential assumptions' with which Quine famously attempted to saddle it. I argue, first, that the ontological issue is at best secondary: the crucial issue about
Heck, Richard Kimberly
core  

Arnošt Kolman’s Critique of Mathematical Fetishism [PDF]

open access: yes, 2020
Arnošt Kolman (1892–1979) was a Czech mathematician, philosopher and Communist official. In this paper, we would like to look at Kolman’s arguments against logical positivism which revolve around the notion of the fetishization of mathematics.
Mácha, Jakub, Zouhar, Jan
core   +1 more source

Logicism Revisited

open access: yesPrincipia: An International Journal of Epistemology, 2001
In this paper, I develop a new defense of logicism: one that combines logicism and nominalism. First, I defend the logicist approach from recent criticisms; in particular from the charge that a crucial principle in the logicist reconstruction of ...
Otávio Bueno
doaj  

A Scoping Review on Artificial Intelligence–Supported Interventions for Nonpharmacologic Management of Chronic Rheumatic Diseases

open access: yesArthritis Care &Research, EarlyView.
This review summarizes artificial intelligence (AI)‐supported nonpharmacological interventions for adults with chronic rheumatic diseases, detailing their components, purpose, and current evidence base. We searched Embase, PubMed, Cochrane, and Scopus databases for studies describing AI‐supported interventions for adults with chronic rheumatic diseases.
Nirali Shah   +5 more
wiley   +1 more source

PENGARUH PEMIKIRAN WITTGENSTEIN TERHADAP MATEMATIKA

open access: yesJurnal Filsafat, 2017
Wittgenstein is a unique philosopher. He criticizes his own opinion. Philosophers divide his views in two periods that are early and later. The early of Wittgentein’s view set by Tractatus Logico Philosophicus and the later set by Philosophical ...
Hardi Suyitno
doaj   +1 more source

Validation of the Pediatric Arthritis Ultrasound Scoring System for the Elbow, Wrist, and Finger Joints in Children With Juvenile Idiopathic Arthritis

open access: yesArthritis Care &Research, EarlyView.
Objective We aimed to validate the Pediatric Arthritis Ultrasound Scoring System (PAUSS) for upper extremity joints in children with juvenile idiopathic arthritis (JIA). Methods Children with JIA were evaluated for elbow, wrist, or finger arthritis by clinical examination (CE) and musculoskeletal ultrasound (MSUS) with images scored according to the ...
Patricia Vega‐Fernandez   +12 more
wiley   +1 more source

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