Results 91 to 100 of about 1,997 (174)

Efecto del fármaco hipolipemiante lomitapide sobre el desarrollo tumoral hepático. La importancia del contexto celular y metabólico

, 2022
Lomitapide es un fármaco aprobado para su uso como agente hipolipemiante para el tratamiento de la hipercolesterolemia familiar homocigótica debido a su acción como inhibidor específico de la proteína microsomal de transferencia de triglicéridos (MTP).
Comanzo, Carla Gabriela
core   +1 more source

Breaking barriers: Innovative therapies for managing homozygous familial hypercholesterolemia

Experimental and Molecular Pathology
Homozygous familial hypercholesterolemia (HoFH) is a rare autosomal recessive disorder characterized by variants in genes involved in the regulation of low-density lipoprotein cholesterol (LDL-C) metabolism.
Shuai-Jie Huang, Ping Huang, Nan-Nan Song, Xian-Hui Jia, Hong-Li Gao, Zhi-Yuan Lu, Xiao-Lan Wen   +6 more
doaj   +1 more source

Lomitapide as a Novel Therapeutic Agent in Breast Cancer: Mechanism and Potential Implications

Introduction: Breast cancer treatment remains challenged by molecular heterogeneity and drug resistance, highlighting the need for new therapeutic strategies.
Xin-Ning Yu, Jing Liu, Wen-Jia Chen, Hua-Tao Wu, Yang-Zheng Lan, Bing-Xuan Wu   +5 more
core   +1 more source

Unlocking the mysteries of VLDL: exploring its production, intracellular trafficking, and metabolism as therapeutic targets

Lipids in Health and Disease
Reducing circulating lipid levels is the centerpiece of strategies for preventing and treating atherosclerotic cardiovascular disease (ASCVD). Despite many available lipid-lowering medications, a substantial residual cardiovascular risk remains.
Jingfei Chen, Zhenfei Fang, Qin Luo, Xiao Wang, Mohamad Warda, Avash Das, Federico Oldoni, Fei Luo   +7 more
doaj   +1 more source

Dislipidemias, ¿qué hay de nuevo?

Revista del Hospital Italiano de Buenos Aires
En los últimos años han surgido algunas investigaciones y guías de práctica clínica relacionadas con el diagnóstico y tratamiento de las dislipidemias, que aportaron nuevos conocimientos (y controversias) sobre dicha problemática.
Walter Masson
doaj  

In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy

Scientific Reports
Due to considerable global prevalence and high recurrence rate, the pursuit of effective new medication for epilepsy treatment remains an urgent and significant challenge. Drug repurposing emerges as a cost-effective and efficient strategy to combat this
Xiaoying Lv, Jia Wang, Ying Yuan, Lurong Pan, Qi Liu, Jinjiang Guo   +5 more
doaj   +1 more source

Machine learning, molecular docking and simulation studies reveal Lomitapide, Lodipamide, Zafirlukast, Netupitant and Salmon Calcitonin as potent drug molecules against Chagas disease

bioRxiv
Trypanosoma cruzi (T. cruzi), a protozoan parasite, is the pathogen that causes the hazardous disease Chagas, sometimes referred to as American trypanosomiasis. Currently, there are just two drugs commercially available to treat this fatal condition. So,
Kavya Singh, Navjeet Kaur, Ashish Prabhu
semanticscholar   +1 more source

Role of S-palmitoylation in digestive system diseases

Cell Death Discovery
Digestive system diseases, including liver diseases, gastrointestinal cancers, and inflammatory bowel diseases, pose major health challenges worldwide.
Hanqing Li, Qiuxiang Yuan, Shuangshuang Wang, Tao Yu, Xingsi Qi   +4 more
doaj   +1 more source

Management of homozygous familial hypercholesterolemia in real-world clinical practice: A report of 7 Italian patients treated in Rome with lomitapide and lipoprotein apheresis

, 2016
Homozygous familial hypercholesterolemia (HoFH) is a rare, genetically determined condition of highly elevated low-density lipoprotein cholesterol (LDLC) levels.
MOROZZI, CLAUDIA, Grossi, Alberto, STEFANUTTI, Claudia, DI GIACOMO, SERAFINA, MESCE, DARIO, SOVRANO, Barbara   +5 more
core   +1 more source

A machine-learning algorithm using claims data to identify patients with homozygous familial hypercholesterolemia

Scientific Reports
Homozygous familial hypercholesterolemia (HoFH) is an underdiagnosed and undertreated ultra-rare disease. We utilized claims data from the Komodo Healthcare Map database to develop a machine-learning model to identify potential HoFH patients.
Jing Gu, Matthew Epland, Xinshuo Ma, Jina Park, Robert J. Sanchez, Ying Li   +5 more
doaj   +1 more source