Results 101 to 110 of about 1,690 (152)

Ovarian expression of functional MTTP and apoB for VLDL assembly and secretion in chickens. [PDF]

Poult Sci
Chen YH, Dettipponpong P, Sin MY, Chang LC, Cheng CY, Huang SY, Walzem RL, Cheng HC, Chen SE.   +8 more
europepmc   +1 more source

Innovative Lipid-Lowering Strategies: RNA-Based, Small Molecule, and Protein-Based Therapies. [PDF]

Endocrinol Metab (Seoul)
Jang Y, Rhee EJ, Choi SH.
europepmc   +1 more source

Reply to Blom: Drugs Do Not Work in Patients Who Cannot Tolerate Them. [PDF]

Glob J Qual Saf Healthc
Esba LCA, Alharbi H.
europepmc   +1 more source

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Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma

Cancer Letters
Multiple myeloma (MM) is a hematological malignancy that remains incurable, primarily due to the high likelihood of relapse or development of resistance to current treatments.
Yuxing Hu, Yingqi Qiu, Yuhua Li
exaly   +2 more sources

Long-term experience with lomitapide treatment in patients with homozygous familial hypercholesterolemia: Over 10 years of efficacy and safety data.

Journal of Clinical Lipidology
BACKGROUND Homozygous familial hypercholesterolemia (HoFH) is a rare disease characterized by loss of low-density lipoprotein receptor (LDLR) function, an extreme elevation of circulating low-density lipoprotein cholesterol (LDL-C) from birth and ...
Marcello Arca, L. D’Erasmo, M. Cuchel, Dirk J Blom, J. Cegla, P. Duell, Raul D Santos, Sallyann O’Brien   +7 more
semanticscholar   +1 more source

Efficient Delivery of Lomitapide using Hybrid Membrane‐Coated Tetrahedral DNA Nanostructures for Glioblastoma Therapy

Advances in Materials
Glioblastoma (GBM) is the most aggressive and prevalent primary malignant tumor of the central nervous system. Traditional chemotherapy has poor therapeutic effects and significant side effects due to drug resistance, the natural blood‐brain barrier (BBB)
Mingming Song, Jiameng Tian, Li Wang, Shuqi Dong, Kun Fu, Siyu Chen, Chang Liu   +6 more
semanticscholar   +1 more source

Lomitapide-induced fatty liver is a reversible condition: Evidence from a case of familial chylomicronemia syndrome.

Journal of Clinical Lipidology
Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder characterized by severe hypertriglyceridemia. It is caused by loss-of-function variants in the genes encoding the lipoprotein lipase (LPL) enzyme and its cofactors, which ...
D. Tramontano, M. D. Martino, F. Baratta, A. D. Costanzo, N. Cocomello, Daniela Commodari, Simone Bini, I. Minicocci, Marcello Arca, L. D’Erasmo   +9 more
semanticscholar   +1 more source

Long-term efficacy and safety of lomitapide in patients with familial chylomicronemia syndrome: Data from an expanded access program.

Journal of Clinical Lipidology
BACKGROUND Familial chylomicronemia syndrome (FCS) is a rare, severe, autosomal recessive disorder characterized by extremely high triglyceride (TG) levels and an increased risk of acute and/or recurrent pancreatitis.
A. Giammanco, L. D’Erasmo, G. Iannuzzo, D. Noto, A. Montali, A. Zambon, F. Forte, P. Suppressa, S. Giannini, C. Barbagallo, C. Gagliardo, Emilio Nardi, D. Tramontano, G. Brancatelli, Marcello Arca, A. Cefalù, M. Averna   +16 more
semanticscholar   +1 more source

Co-encapsulation of norcantharidin prodrugs and lomitapide in nanoparticles to regulate CCL4 expression by inhibiting Wnt/β-catenin pathway for improved anti-tumor immunotherapy

Journal of Nanobiotechnology
In the absence of tumor antigen specificity, direct chemokine administration carries the risk of significant “on-target, off-tumor” toxicities, highlighting the need for small-molecule approaches with reduced immunogenicity.
Feng Zhao, Liming Gong, Ping Wang, Dong Chen, Shijie Cao, Feifei Yang, Manqing Tang, Yuanyuan Meng, Yuming Wang, Lin Miao, Yunfei Li, Wei Huang   +11 more
semanticscholar   +1 more source

Resistance to conventional drug therapy and good response to lomitapide allowed the identification of a novel bi-allelic semi-dominant monogenic HoFH: a case report

Current Medical Research and Opinion
Introduction Familial hypercholesterolaemia (FH) is a genetic disorder associated with high cholesterol levels and an increased risk of premature cardiovascular events.
Paolo Fornengo, Simone Mattivi, Elisa Rinaudo, Federica Lepore, Ileana Iemmolo, Valeria Bracciamà, G. B. D. del Prever, A. Faini, Marilena Durazzo, Silvia Deaglio   +9 more
semanticscholar   +1 more source