Results 121 to 130 of about 6,876,355 (238)

Real-life effectiveness of indacaterol/glycopyrronium/mometasone for symptomatic relief of cough after switching from inhaled corticosteroid/long-acting β₂-agonist therapy in patients with asthma: REACH study design. [PDF]

ERJ Open Res, 2023
Niimi A, Kanemitsu Y, Tajiri T, Sumi K, Mikami T, Kondo N.   +5 more
europepmc   +1 more source

A novel, long-acting glucagon-like peptide receptor-agonist: dulaglutide

, 2015
Tara Gurung,1 Deepson S Shyangdan,1 Joseph Paul O’Hare,2 Norman Waugh1 1Warwick Evidence, 2Division of Metabolic and Vascular Health, Warwick Medical School, University of Warwick, Coventry, UK Background: Dulaglutide is a new, long-acting glucagon-
Shyangdan DS, O’Hare JP, Gurung T, Waugh N   +3 more
core  

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

British Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Characterisation of patients with chronic obstructive pulmonary disease initiating single-device inhaled corticosteroids/long-acting β₂-agonist dual therapy in a primary care setting in England. [PDF]

BMJ Open Respir Res, 2022
Czira A, Banks V, Requena G, Wood R, Tritton T, Wild R, Compton C, Duarte M, Ismaila AS.   +8 more
europepmc   +1 more source

Rapid nongenomic actions of inhaled corticosteroids on long-acting β2-agonist transport in the airway

, 2011
Corticosteroids inhibit organic cation transporters (OCTs) that play an important role in drug absorption, tissue distribution and elimination. Corticosteroid sensitivity of bronchodilator trafficking in the airway tissue, however, is poorly understood ...
Andreas Schmid, Schmid, Nathalie, Nathalie Schmid, Gabor Horvath, Nevis L. Fregien, Wanner, Adam, Matthias Salathe, Eliana S. Mendes, Salathe, Matthias, Conner, Gregory E, Fregien, Nevis L, Mendes, Eliana S, Horvath, Gabor, Schmid, Andreas, Gregory E. Conner, Adam Wanner   +15 more
core   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

MODERN VIEW ON THE LONG ACTING β2-AGONISTS IN THERAPY FOR THE BRONCHIAL ASTHMA AMONG CHILDREN

, 2008
The article deals with the long acting β2-agonists in therapy of children, suffering from the bronchial asthma, with regards to the recommendations of the modern manuals.
L.S. Namazova, Yu.G. Levina
core  

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Potentiation of long-acting β₂-agonist and glucocorticoid responses in human airway epithelial cells by modulation of intracellular cAMP. [PDF]

Respir Res, 2021
Kim Y, Hou V, Huff RD, Aguiar JA, Revill S, Tiessen N, Cao Q, Miller MS, Inman MD, Ask K, Doxey AC, Hirota JA.   +11 more
europepmc   +1 more source

Figure_S5 – Supplemental material for Systematic review and network meta-analysis of the efficacy and safety of glycopyrrolate/formoterol fumarate metered dose inhaler in comparison with other long-acting muscarinic antagonist/long-acting β₂-agonist fixed-dose combinations in COPD

, 2019
Supplemental material, Figure_S5 for Systematic review and network meta-analysis of the efficacy and safety of glycopyrrolate/formoterol fumarate metered dose inhaler in comparison with other long-acting muscarinic antagonist/long-acting β2-agonist fixed-
Patrick Darken (3584720), Martin Jenkins (6279593), Mousumi Biswas (8179512), Mario Ouwens (2560255), Deniz Guranlioglu (8179509), Mohd Kashif Siddiqui (4636669), Pragya Shukla (4891924)   +6 more
core   +1 more source