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Status of long-acting-growth hormone preparations — 2015
Growth Hormone and IGF Research, 2015Growth hormone (GH) treatment has been an established therapy for GH deficiency (GHD) in children and adults for more than three decades. Numerous studies have shown that GH treatment improves height, body composition, bone density, cardiovascular risk factors, physical fitness and quality of life and that the treatment has few side effects.
Pinchas Cohen +2 more
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Long-acting growth hormone in the treatment of children with growth hormone deficiency
Expert Review of Endocrinology and MetabolismThe introduction of long-acting formulations in recent years is changing the landscape of growth hormone (GH) therapy. Daily recombinant human GH (rhGH) has been the treatment of choice for children and adults with GH deficiency (GHD), since its approval in 1985. However, decreasing adherence to treatment over time has been identified as a cause of the
Barbara Predieri +2 more
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Somapacitan: a long-acting growth hormone derivative for treatment of growth hormone deficiency
Drugs of Today, 2022Growth hormone deficiency (GHD) is characterized by inadequate HG production from the anterior pituitary gland. Adult patients with GHD have increased fat mass, an abnormal lipid profile, decreased lean body mass and bone mineral density, decreased muscle strength and exercise endurance, and a diminished quality of life.
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Long-Acting Growth Hormone: An Update
2015After the introduction of recombinant human growth hormone (rhGH) in 1985, a myriad of children and adults have benefited from its growth-promoting and metabolic effects. Nowadays, current therapeutic regimens rely on daily subcutaneous GH injections that could be burdensome and inconvenient to pediatric patients.
Paul H, Saenger, Jorge, Mejia-Corletto
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The current state of long-acting growth hormone preparations for growth hormone therapy
Current Opinion in Endocrinology, Diabetes & Obesity, 2018Purpose of review To discuss the rationale of developing long-acting growth hormone (LAGH) preparations, to describe the technologies designed to prolong GH action, and to address key issues regarding efficacy, safety, and monitoring while on treatment.
Kevin C J, Yuen +2 more
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Long-acting Growth Hormone Preparations
Endocrinology and Metabolism Clinics of North AmericaOnce-weekly long-acting growth hormone (LAGH) preparations have demonstrated noninferiority compared to daily recombinant human growth hormone in terms of increased growth velocity and improved body composition with comparable short-term safety profiles in children with growth hormone deficiency (CGHD) and adults with growth hormone deficiency (AGHD ...
Kevin C J, Yuen +1 more
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Long-Acting Growth Hormone Analogues
2011Growth hormone (GH) is an anabolic cytokine hormone regulating linear growth in childhood and normal body composition in adults. The current therapeutic regimen for GH replacement requires once-daily subcutaneous injections which is inconvenient and expensive.
Alice Thorpe +4 more
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Novel Long-Acting Crystal Formulation of Human Growth Hormone
Pharmaceutical Research, 2005The aim of the study is to solve a significant challenge of extending the half-life of therapeutic proteins using crystalline biopharmaceuticals and without redesigning the molecules.Crystals of recombinant human growth hormone were coated with a monomolecular layer of positively charged poly(arginine). The pharmacokinetics and pharmacodynamics of this
Chandrika, Govardhan +9 more
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Long-acting growth hormone in the management of GHD in France
Archives de PédiatrieApproximately 10,000 children in France with growth hormone deficiency (GHD) are being administered daily recombinant human growth hormone (rhGH). Although this treatment has long proved efficient for restoring children's growth and metabolism, daily injections of rhGH have a few limitations, such as difficulties in terms of adherence to treatment ...
Agnès Linglart +3 more
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Update on the use of long-acting growth hormone in children
Current Opinion in PediatricsPurpose of review After extensive research and many years of waiting, long-acting growth hormone (LAGH) formulations have finally become a reality in clinical practice and emerge as a potential solution to address the challenges of daily injections of recombinant human GH (rhGH).
Margaret Cristina da Silva, Boguszewski +1 more
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