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Long-acting growth hormones: innovations in treatment and guidance on patient selection in pediatric growth hormone deficiency [PDF]

Annals of Pediatric Endocrinology & Metabolism
Long-acting growth hormones (LAGHs) represent a significant advancement in the treatment of pediatric GH deficiency, offering an alternative to daily recombinant human GH (rhGH) therapy.
Chiara Rodaro, Gianluca Tamaro, Elena Faleschini, Gianluca Tornese   +3 more
doaj   +7 more sources

Treatment Adherence to Injectable Treatments in Pediatric Growth Hormone Deficiency Compared With Injectable Treatments in Other Chronic Pediatric Conditions: A Systematic Literature Review [PDF]

Frontiers in Endocrinology, 2022
BackgroundPediatric patients with growth hormone deficiency (GHD) are currently treated with daily injections of recombinant human growth hormone (rhGH) to promote linear growth and enable attainment of normal adult height.
Roy Gomez, S. Faisal Ahmed, Mohamad Maghnie, Mohamad Maghnie, Dejun Li, Toshiaki Tanaka, Bradley S. Miller   +6 more
doaj   +4 more sources

Long-Acting Growth Hormone for Pediatric Growth Hormone Deficiency. [PDF]

J Endocr Soc
Abstract Long-acting growth hormone (LAGH) has the potential to improve adherence and outcomes over daily somatropin in growth hormone deficiency (GHD). Whereas daily somatropin products are molecularly identical, LAGHs are molecularly distinct; additional moieties or mechanisms that prolong LAGH action confer unique pharmacodynamic ...
Albers N, Cadarette S, Feakins B, Arregui M, Ebohon S, Lai P, Raveendran S, Kjelgaard-Hansen M, Andersen C, Zhao C, Smith A, Geffner M.   +11 more
europepmc   +4 more sources

Somatrogon in pediatric growth hormone deficiency: a comprehensive review of clinical trials and real-world considerations [PDF]

Annals of Pediatric Endocrinology & Metabolism
Growth hormone (GH) is crucial for childhood growth and body composition. In pediatric GH deficiency (pGHD), the pituitary gland fails to produce sufficient GH, which affects linear growth in childhood.
Aristides K. Maniatis, Michael P. Wajnrajch, Marc Thomas, Sung Beom Chung, Jieun Lee   +4 more
doaj   +4 more sources

Obesity-Related Changes in Growth Hormone Stimulation Test Performance Under Pediatric Growth Hormone Deficiency [PDF]

Children
Background/Objectives: The objective of this study is to determine the extent to which obesity alters the diagnostic reliability of the clonidine stimulation test (CST) for growth hormone deficiency (GHD) and whether incorporating insulin-like growth ...
Semine Ozdemir Dilek, Fatma Özgüç Comlek   +1 more
doaj   +5 more sources

Long-Acting Growth Hormone Therapy in Pediatric Growth Hormone Deficiency: A Consensus Statement.

J Clin Endocrinol Metab
Abstract Context Several long-acting growth hormone (LAGH) therapies have recently become available, but guidance on their usage in children with growth hormone (GH) deficiency is limited. Methods International experts in pediatric ...
Maniatis A, Cutfield W, Dattani M, Deal C, Collett-Solberg PF, Horikawa R, Maghnie M, Miller BS, Polak M, Sävendahl L, Woelfle J.   +10 more
europepmc   +4 more sources

Growth hormone deficiency and the transition from pediatric to adult care

Jornal de Pediatria, 2021
Objective: To discuss the approach to patients diagnosed with growth hormone deficiency (GHD) in childhood during the transition period from puberty to adulthood, focusing on the following: (1) physiology; (2) effects of recombinant human GH (rhGH ...
Ana Beatriz Winter Tavares, Paulo Ferrez Collett-Solberg   +1 more
doaj   +5 more sources

Delphi-based Spanish consensus on the use of long-acting growth hormone in pediatric growth hormone deficiency: recommendations from the ConverGHe Working Group [PDF]

Frontiers in Endocrinology
BackgroundLong-acting growth hormone (LAGH) formulations have emerged as an alternative to daily recombinant human growth hormone (rhGH) in pediatric growth hormone deficiency (GHD).
Lidia Castro-Feijóo, José-Ignacio Labarta-Aizpún, Marta Ramon-Krauel, Diana Primiano, Diego Yeste Fernández, Isabel González Casado   +5 more
doaj   +2 more sources

Can long-acting growth hormone improve adherence in pediatric growth hormone deficiency? [PDF]

Endocrine
Abstract Growth hormone deficiency (GHD) in childhood and adolescence requires long-term therapy with recombinant human growth hormone (rhGH). Although daily injections are highly effective, they impose a considerable treatment burden that often leads to suboptimal adherence and compromised growth outcomes.
Rodaro C, Tamaro G, Fachin A, Nicolardi F, Tommasi S, Tornese G.   +5 more
europepmc   +3 more sources

Spotlight on Lonapegsomatropin Once-Weekly Injection and Its Potential in the Treatment of Growth Hormone Deficiency in Pediatric Patients

Drug Design, Development and Therapy, 2022
Bradley S Miller,1 Kevin CJ Yuen2 1Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, MN, USA; 2Department of Neuroendocrinology and Neurology, Barrow Pituitary Center, University of Arizona College of Medicine and Creighton ...
Miller BS, Yuen KCJ
doaj   +2 more sources