Neonatal Symptoms in Pediatric Idiopathic Growth Hormone Deficiency: Prevalences and Insights
ChildrenBackground: Growth hormone deficiency (GHD) is one of the primary endocrine-related causes of short stature in pediatric patients; while neonatal GHD symptoms are well-documented in populations with known genetic and/or organic causes, their exact ...
Giorgio Sodero +2 more
doaj +6 more sources
Long-Acting Growth Hormone for Pediatric Growth Hormone Deficiency. [PDF]
J Endocr SocAbstract Long-acting growth hormone (LAGH) has the potential to improve adherence and outcomes over daily somatropin in growth hormone deficiency (GHD). Whereas daily somatropin products are molecularly identical, LAGHs are molecularly distinct; additional moieties or mechanisms that prolong LAGH action confer unique pharmacodynamic ...
Albers N +11 more
europepmc +4 more sources
Long-Acting Growth Hormone Therapy in Pediatric Growth Hormone Deficiency: A Consensus Statement.
J Clin Endocrinol MetabAbstract Context Several long-acting growth hormone (LAGH) therapies have recently become available, but guidance on their usage in children with growth hormone (GH) deficiency is limited. Methods International experts in pediatric ...
Maniatis A +10 more
europepmc +4 more sources
Growth hormone deficiency and the transition from pediatric to adult care
Jornal de Pediatria, 2021 Objective: To discuss the approach to patients diagnosed with growth hormone deficiency (GHD) in childhood during the transition period from puberty to adulthood, focusing on the following: (1) physiology; (2) effects of recombinant human GH (rhGH ...
Ana Beatriz Winter Tavares +1 more
doaj +5 more sources
Isolated Growth Hormone Deficiency
EndocrinesGrowth hormone deficiency (GHD) is the most frequent pituitary hormone deficiency in childhood, with an incidence of 1 in 4000–10,000 live births. GHD can be congenital (genetic or due to hypothalamic/pituitary abnormalities) or acquired and can be ...
Anastasia Ibba +3 more
doaj +2 more sources
Developing a Process for Preference Measures in Pediatric Growth Hormone Deficiency: Challenges and Solutions. [PDF]
Patient Prefer AdherencePatient experience data capturing the patient voice is gaining increasing recognition across the drug development continuum for use in risk/benefit analysis to evaluate new drugs. The aim of this study was to delineate a prototype process for and then, following this process, develop questionnaires to rigorously assess patient-centric treatment ...
Brod M +7 more
europepmc +5 more sources
Evaluation of cases with growth hormone deficiency
Acta Medica Alanya, 2019 Aim:The purpose of this study was to elicit data concerning the clinical and laboratory features of children with growth hormone deficiency monitored by the Pediatric Endocrinology and Metabolism Polyclinic in order to produce useful information for ...
Meltem Di̇rek +3 more
doaj +2 more sources
Once-Weekly Somatrogon in Pediatric Growth Hormone Deficiency: Real-World Efficacy, Safety, and Quality-of-Life Findings [PDF]
JCRPEObjective: To report real-world 6- and 12-month outcomes in children with growth hormone deficiency (GHD) treated with somatrogon or somatropin, including those who transitioned from somatropin to somatrogon.
Kübra Şen Küçük +5 more
doaj +2 more sources
Comparison between long-acting pegylated and daily recombinant human growth hormone for pediatric growth hormone deficiency a systematic review [PDF]
Scientific ReportsThis systematic review aims to summarize the therapeutic benefits and safety profile of long-acting PEGylated recombinant human growth hormone (PEG‑rhGH) compared with daily recombinant human growth hormone (DGH) in pediatric growth hormone deficiency ...
Jun Zhang +3 more
doaj +2 more sources
Editorial: Long-acting growth hormone therapy in pediatric growth hormone deficiency [PDF]
Frontiers in EndocrinologyAnastasia Ibba +3 more
doaj +2 more sources