Results 141 to 150 of about 13,157 (218)

The Bronchodilator and Anti‐Inflammatory Effect of Long‐Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper

Allergy
ABSTRACTAs cholinergic innervation is a major contributor to increased vagal tone and mucus secretion, inhaled long‐acting muscarinic antagonists (LAMA) are a pillar for the treatment of chronic obstructive pulmonary disease and asthma. By blocking the muscarinic receptors expressed in the lung, LAMA improve lung function and reduce exacerbations in ...
Agache, Ioana, Adcock, Ian, Akdis, Cezmi, Akdis, Mübeccel, Bentabol-Ramos, Guillermo, van den Berge, Maarten, Boccabella, Cristina, Canonica, Walter, Caruso, Cristiano, Couto, Mariana, Davila, Ignacio, Drummond, David, Fonseca, José, Gherasim, Alina, del Giacco, Stefano, Jackson, David, Jutel, Marek, Licari, Amelia, Loukides, Stelios, Moreira, Andreia, Mukherjee, Manali, Ojanguren, Iñigo, Palomares, Oscar, Papi, Alberto, Perez de Llano, Luis, Price, Oliver, Rukhazde, M., Shamji, Mohamed, Shaw, Dominick, Sanchez-Garcia, Silvia, Testera-Montes, Almudena, Torres, Maria José, Eguiluz-Gracia, Ibon   +32 more
openaire   +8 more sources

Hemodynamic consequences of chronic parasympathetic blockade with a peripheral muscarinic antagonist

, 2007
hereas the sympathetic nervous system has a well-established role in blood pressure (BP) regulation, it is not clear whether long-term levels of BP are affected by parasympathetic function or dysfunction. We tested the hypothesis that chronic blockade
Van Vliet, Bruce N, Dulloo, Abdul G., Antic, Vladan, Vliet, Bruce N. Van, Ayer, Antoine, Dulloo, Abdul G, Montani, Jean-Pierre   +6 more
core   +1 more source

Improvement in 24-hour bronchodilation and symptom control with aclidinium bromide versus tiotropium and placebo in symptomatic patients with COPD: post hoc analysis of a Phase IIIb study

International Journal of COPD, 2017
Jutta Beier,1 Robert Mroz,2,3 Anne-Marie Kirsten,4 Ferran Chuecos,5 Esther Garcia Gil5 1insaf Respiratory Research Institute, Wiesbaden, Germany; 2Centrum Medycyny Oddechowej, 3Medical University of Białystok, Białystok, Poland; 4Pulmonary Research ...
Beier J, Mroz R, Kirsten AM, Chuecos F, Garcia Gil E   +4 more
doaj  

Revefenacin: A Once-Daily, Long-Acting Bronchodilator For Nebulized Treatment Of COPD

International Journal of COPD, 2019
James F Donohue,1 Donald A Mahler,2,3 Sanjay Sethi4 1Pulmonary Medicine, UNC School of Medicine, Chapel Hill, NC, USA; 2Geisel School of Medicine at Dartmouth, Hanover, NH, USA; 3Director of Respiratory Services, Valley Regional Hospital, Claremont, NH ...
Donohue JF, Mahler DA, Sethi S
doaj  

Inhaled glycopyrrolate for the treatment of chronic obstructive pulmonary disease

International Journal of COPD, 2018
Donald P Tashkin,1 Nicholas J Gross2 1Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2Department of Medicine, University Medical Research LLC, Saint Francis Hospital and Medical Center, Hartford, CT, USA Abstract:
Tashkin DP, Gross NJ
doaj  

Activity of aclidinium bromide, a new long-acting muscarinic antagonist: a phase I study

, 2010
AIM: Aclidinium bromide is a muscarinic antagonist in development for the treatment of chronic obstructive pulmonary disease (COPD). This phase I trial in healthy subjects investigated the bronchodilator activity of aclidinium and its ability to reduce ...
Schelfhout, Vanessa, Joos, Guy, Jansat, Josep, Peris, Francesc, Gil, Esther, Ferrer, Pau, Pauwels, Romain   +6 more
core   +1 more source

Inhaled treatment of COPD: a Delphi consensus statement

International Journal of COPD, 2017
Vincent Ninane,1 Jean-Louis Corhay,2 Paul Germonpré,3 Wim Janssens,4 Guy F Joos,5 Giuseppe Liistro,6 Walter Vincken,7 Sandra Gurdain,8 Evelyne Vanvlasselaer,8 An Lehouck8 1Department of Respiratory Medicine, Saint-Pierre Hospital, Universit ...
Ninane V, Corhay JL, Germonpré P, Janssens W, Joos GF, Liistro G, Vincken W, Gurdain S, Vanvlasselaer E, Lehouck A   +9 more
doaj  

Impact and prevention of severe exacerbations of COPD: a review of the evidence

International Journal of COPD, 2017
David MG Halpin,1 Marc Miravitlles,2 Norbert Metzdorf,3 Bartolomé Celli4 1Department of Respiratory Medicine, Royal Devon and Exeter Hospital, Exeter, UK; 2Pneumology Department, Hospital Universitari Vall d’Hebron, CIBER de Enfermedades ...
Halpin DMG, Miravitlles M, Metzdorf N, Celli B   +3 more
doaj  

Long-acting muscarinic antagonist regulates group 2 innate lymphoid cell-dependent airway eosinophilic inflammation

博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨Background: Tiotropium bromide, a long-acting muscarinic antagonist, reduces the frequency of exacerbation in patients with moderate to severe asthma, but its underlying mechanism is not clear.
マツヤマ, タカヒロ, 松山, 崇弘, Matsuyama, Takahiro   +2 more
core  

Profile of glycopyrronium for once-daily treatment of moderate-to-severe COPD

International Journal of COPD, 2012
Roland Buhl,1 Donald Banerji21Pulmonary Department, Mainz University Hospital, Mainz, Germany; 2Novartis Pharmaceuticals Corporation, East Hanover, NJ, USAAbstract: Bronchodilators are central in the symptomatic management of chronic obstructive ...
Buhl R, Banerji D
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