Results 131 to 140 of about 13,157 (218)

Comparison of efficacy of long-acting bronchodilators in emphysema dominant and emphysema nondominant chronic obstructive pulmonary disease

, 2011
Keisaku Fujimoto1, Yoshiaki Kitaguchi2, Shintaro Kanda2, Kazuhisa Urushihata2, Masayuki Hanaoka2, Keishi Kubo21Department of Biomedical Laboratory Sciences, 2First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano,
Urushihata K, Kitaguchi Y, Hanaoka M, Kubo K, Kanda S, Fujimoto K   +5 more
core  

Prehospital Use of Non‐Invasive Ventilation for Acute Respiratory Failure due to Acute Exacerbation of Chronic Obstructive Pulmonary Disease. A Randomised Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background In‐hospital use of non‐invasive ventilation improves outcomes in patients with acute respiratory failure caused by acute exacerbation of chronic obstructive pulmonary disease. Prehospital use of non‐invasive ventilation is uncommon due to diagnostic uncertainty and logistical constraints.
Jesper H. Brendel, Lars W. Andersen, Søren H. Skaarup, Thomas Dissing, Anders Gunnar Nielsen, Nikolaj F. Milandt, Ulrick S. Espelund, Lisa F. Irion, Lone R. Mortensen, Kim M. Larsen, Jens Aage K. Petersen   +10 more
wiley   +1 more source

Chemogenetic Stimulation of the Dorsal Motor Nucleus of the Vagus Mitigates Autonomic Dysfunction and Memory Decline in Rat Model of Alzheimer‐Like Disease

Acta Physiologica, Volume 242, Issue 7, July 2026.
ABSTRACT Aim To test the hypothesis that Alzheimer‐like metabolic neurodegeneration rat model leads to an autonomic dysfunction, memory impairment, and hippocampal amyloid pathology and that long‐term chemogenetic stimulation of the dorsal motor nucleus of the vagus reverses these alterations. Methods Male and female transgenic Long Evans rats received
Beatriz Pacheco Sousa, Karoline Martins dos Santos, Vagner Roberto Antunes   +2 more
wiley   +1 more source

Envolvimento dos receptores B1 e B2 para as cininas na hiperatividade da bexiga urinária induzida por lesão medular em ratos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2011O envolvimento dos receptores B1 e B2 para as cininas em processos fisiopatológicos da bexiga ...
Forner, Stefânia
core  

The amino terminal domain of the human α7 nicotinic acetylcholine receptor subunit leads to the functional expression of human/insect receptors

British Journal of Pharmacology, Volume 183, Issue 13, Page 3517-3537, July 2026.
Human α7 receptors have been characterised in terms of pharmacological properties. Insertion of the N‐terminal domain of the human α7 subunit leads to honeybee and cockroach chimeric receptors activated by ACh and inhibited by α‐Bgt. Insertion of the human cys‐loop leads to cockroach chimeric receptors modulated by PNU.
Alison Cartereau, Chloé Veront, Alexandra Cremades, Priscilla Martin, Remi Gojard, Nicolas Galland, Emiliane Taillebois, Dieudonnée Togbé, Jean‐Yves Le Questel, Steeve H. Thany   +9 more
wiley   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Don't Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
A new galvanic skin response‐based approach offers a simple method for measuring sweating in the paws of mice. This method is used to demonstrate that cannabinoid CB1 receptors reduce baseline sweating in mice, likely via inhibition of sympathetic acetylcholine release via axonal CB1 receptors.
Natalia Murataeva, Joseph Youkilis, Yogith Rao, Alex Straiker   +3 more
wiley   +1 more source

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Farideh A. Javid, Javid, Farideh A., Mashhadi, Farzaneh Farajian, Robert J. Naylor, Farzaneh Farajian Mashhadi, Naylor, Robert J.   +5 more
core   +1 more source

Tiotropium bromide (Ba 679 BR), a novel long-acting muscarinic antagonist for the treatment of obstructive airways disease

, 1995
Tiotropium bromide (Ba 679 BR) is a novel potent and long-lasting muscarinic antagonist that has been developed for the treatment of chronic obstructive airways disease (COPD). Binding studies with [3H]tiotropium bromide in human lung have confirmed that
Belvisi, MG, Judith C.W. Mak, Barnes, PJ, El-Bdaoui Haddad, Peter J Barnes, O'connor, B, Mak, JCW, Haddad, EB, Maria G Belvisi, Brian O'Connor   +9 more
core   +1 more source

New developments in the combination treatment of COPD: focus on umeclidinium/vilanterol

Drug Design, Development and Therapy, 2013
Mario Cazzola,1 Andrea Segreti,1 Maria Gabriella Matera2 1Department of System Medicine, University of Rome 'Tor Vergata', Rome, Italy; 2Department of Experimental Medicine, Second University, Naples, Italy Abstract: An increasing body of ...
Cazzola M, Segreti A, Matera MG
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