Results 111 to 120 of about 12,025 (204)

New developments in the combination treatment of COPD: focus on umeclidinium/vilanterol

Drug Design, Development and Therapy, 2013
Mario Cazzola,1 Andrea Segreti,1 Maria Gabriella Matera2 1Department of System Medicine, University of Rome 'Tor Vergata', Rome, Italy; 2Department of Experimental Medicine, Second University, Naples, Italy Abstract: An increasing body of ...
Cazzola M, Segreti A, Matera MG
doaj  

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

Clinical potential of aclidinium bromide in chronic obstructive pulmonary disease

Therapeutics and Clinical Risk Management, 2014
Jun Zhong, Michael Roth Pneumology and Pulmonary Cell Research, Department of Biomedicine and Internal Medicine, University Hospital Basel, Basel, Switzerland Abstract: Chronic obstructive pulmonary disease (COPD) is increasing worldwide and is ...
Zhong J, Roth M
doaj  

Parasympathetic Tone Selectively Modulates Electrogram Fragmentation and Spectral Properties in Right Atrial Ganglionated Plexi

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Electrogram fragmentation and spectral EGMs features in GPs area are selectively modulated by parasympathetic tone, as demonstrated by high‐density right atrial mapping before and after vagal blockade. EGMs, bipolar atrial electrograms; GPs, ganglionated plexi; RA, right atrium.
Andrea Giomi, Andrea Bernardini, Alessandro Paoletti Perini, Margherita Padeletti, Cristiano Salvatore Zaccaria, Federica Michelotti, Umberto Signorini, Rossella Marcucci, Massimo Milli   +8 more
wiley   +1 more source

The Bronchodilator and Anti‐Inflammatory Effect of Long‐Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper

Allergy
ABSTRACTAs cholinergic innervation is a major contributor to increased vagal tone and mucus secretion, inhaled long‐acting muscarinic antagonists (LAMA) are a pillar for the treatment of chronic obstructive pulmonary disease and asthma. By blocking the muscarinic receptors expressed in the lung, LAMA improve lung function and reduce exacerbations in ...
Agache, Ioana, Adcock, Ian, Akdis, Cezmi, Akdis, Mübeccel, Bentabol-Ramos, Guillermo, van den Berge, Maarten, Boccabella, Cristina, Canonica, Walter, Caruso, Cristiano, Couto, Mariana, Davila, Ignacio, Drummond, David, Fonseca, José, Gherasim, Alina, del Giacco, Stefano, Jackson, David, Jutel, Marek, Licari, Amelia, Loukides, Stelios, Moreira, Andreia, Mukherjee, Manali, Ojanguren, Iñigo, Palomares, Oscar, Papi, Alberto, Perez de Llano, Luis, Price, Oliver, Rukhazde, M., Shamji, Mohamed, Shaw, Dominick, Sanchez-Garcia, Silvia, Testera-Montes, Almudena, Torres, Maria José, Eguiluz-Gracia, Ibon   +32 more
openaire   +8 more sources

Review of nutrition management of pediatric intestinal pseudo‐obstruction

Nutrition in Clinical Practice, Volume 41, Issue 4, Page 1048-1060, August 2026.
Abstract Chronic intestinal pseudo‐obstruction (CIPO) is a rare, heterogeneous, and debilitating disorder characterized by profound intestinal dysmotility and severe nutrition challenges. Its presentation resembles that of mechanical bowel obstruction, but CIPO occurs in the absence of luminal obstruction.
Senthilkumar Sankararaman, Raisa Rani James, Bushra El‐Amaireh, Andrea Adler, Kadakkal Radhakrishnan, Sujithra Velayuthan   +5 more
wiley   +1 more source

Improvement in 24-hour bronchodilation and symptom control with aclidinium bromide versus tiotropium and placebo in symptomatic patients with COPD: post hoc analysis of a Phase IIIb study

International Journal of COPD, 2017
Jutta Beier,1 Robert Mroz,2,3 Anne-Marie Kirsten,4 Ferran Chuecos,5 Esther Garcia Gil5 1insaf Respiratory Research Institute, Wiesbaden, Germany; 2Centrum Medycyny Oddechowej, 3Medical University of Białystok, Białystok, Poland; 4Pulmonary Research ...
Beier J, Mroz R, Kirsten AM, Chuecos F, Garcia Gil E   +4 more
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In Vivo Evaluation of Psoralen in a Copper Sulfate–Induced Chick (Gallus gallus domesticus) Emesis Model and In Silico Analysis of Its Interaction With D2, 5‐HT3A, and Muscarinic Receptors

ChemistryOpen, Volume 15, Issue 8, August 2026.
Psoralen (PSN) demonstrates significant dose‐dependent antiemetic activity in a copper sulfate–induced chick emesis model. Integrated in vivo and in silico analyses reveal reduced retching frequency, prolonged latency, and favorable multi‐receptor interactions with D2, 5‐HT3A, and muscarinic receptors, highlighting PSN as a promising multi‐target ...
Kishor Chandra, Sharif Uddin Bahar, Khadija Akter, Mst Muslima Khatun, Samiran Sadhukhan, Progna Saha Puja, Fazley Rohan, Md Shimul Bhuia, Mohammed Alfaifi, Faisal H. Altemani, Faisal Alsenani, Salehin Sheikh, Muhammad Torequl Islam   +12 more
wiley   +1 more source

Revefenacin: A Once-Daily, Long-Acting Bronchodilator For Nebulized Treatment Of COPD

International Journal of COPD, 2019
James F Donohue,1 Donald A Mahler,2,3 Sanjay Sethi4 1Pulmonary Medicine, UNC School of Medicine, Chapel Hill, NC, USA; 2Geisel School of Medicine at Dartmouth, Hanover, NH, USA; 3Director of Respiratory Services, Valley Regional Hospital, Claremont, NH ...
Donohue JF, Mahler DA, Sethi S
doaj  

Error Traps in Pediatric Neuromuscular Block

Pediatric Anesthesia, Volume 36, Issue 8, Page 887-898, August 2026.
ABSTRACT Background Neuromuscular blocking agents are essential for safe pediatric anesthesia but remain a frequent source of preventable morbidity when misused, inadequately monitored, or incompletely reversed. Children, particularly neonates and infants, are especially vulnerable to residual neuromuscular block due to developmental pharmacological ...
Gabriel Soares de Sousa, Debra Faulk, Vinicius Caldeira Quintao, Niekoo Abbasian, Hans D. de Boer, Ricardo Vieira Carlos   +5 more
wiley   +1 more source