Results 101 to 110 of about 12,025 (204)

The Neurovascular Niche: A Gathering Venue for Neuroinflammation and Remyelination in Multiple Sclerosis

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT In the central nervous system (CNS), the tissue microenvironment is continuously monitored and regulated to secure the unobstructed function of neurons and of their networks. This is a key function of the neurovascular niche (NVN), which is the interface between the cells of the nervous tissue and the cells and the content of blood vessels. It
Ilias Kazanis, Maria Elena Silva, Alerie G. de la Fuente, Fernando de Castro, Francisco J. Rivera   +4 more
wiley   +1 more source

Deprescription of Psychotropics in Children and Adolescents: Systematic Review of Guidelines and Development of a Deprescribing Algorithm

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Background Psychotropics are increasingly prescribed in paediatrics despite limited evidence regarding their benefits and effectiveness. Although deprescribing approaches are established in adults, structured paediatric strategies remain poorly defined.
Paul‐Benoît Fargier, Mark Horowitz, Rodolphe Charles, Valérie Rousselon, Erik Fakra, Marie‐Noëlle Beyens, Marie‐Laure Laroche   +6 more
wiley   +1 more source

A randomized controlled trial of long-acting muscarinic antagonist and long-acting β2 agonist fixed-dose combinations in patients with chronic obstructive pulmonary disease. [PDF]

BMC Pulm Med, 2021
Muraki M, Kunita Y, Shirahase K, Yamazaki R, Hanada S, Sawaguchi H, Tohda Y.   +6 more
europepmc   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, Volume 183, Issue 17, Page 5389-5406, September 2026.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Predicting treatable traits for long-acting bronchodilators in patients with stable COPD

International Journal of COPD, 2017
Jieun Kang,1,* Ki Tae Kim,2,* Ji-Hyun Lee,3 Eun Kyung Kim,3 Tae-Hyung Kim,4 Kwang Ha Yoo,5 Jae Seung Lee,1 Woo Jin Kim,6 Ju Han Kim,2 Yeon-Mok Oh1 1Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan ...
Kang J, Kim KT, Lee JH, Kim EK, Kim TH, Yoo KH, Lee JS, Kim WJ, Kim JH, Oh YM   +9 more
doaj  

First-Line Treatment with Tiotropium/Olodaterol Improves Physical Activity in Patients with Treatment-Naïve Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2020
Koichiro Takahashi,1 Masaru Uchida,2 Go Kato,3 Ayako Takamori,4 Takashi Kinoshita,5 Makoto Yoshida,6 Ryo Tajiri,4 Keisuke Kojima,7 Hiroshi Inoue,8 Hiromi Kobayashi,9 Hironori Sadamatsu,1 Hiroki Tashiro,1 Masahide Tanaka,1 Shinichiro Hayashi,10 Atsushi ...
Takahashi K, Uchida M, Kato G, Takamori A, Kinoshita T, Yoshida M, Tajiri R, Kojima K, Inoue H, Kobayashi H, Sadamatsu H, Tashiro H, Tanaka M, Hayashi S, Kawaguchi A, Kimura S, Sueoka-Aragane N, Kawayama T   +17 more
doaj  

Functional Specialization of Clathrin‐Independent Endocytic Routes: Mechanisms and Cellular Roles

Traffic, Volume 27, Issue 3, September 2026.
Distinct clathrin‐independent endocytic (CIE) routes support specialized cellular functions across different contexts. Created with Biorender.com. ABSTRACT Clathrin‐independent endocytosis (CIE) comprises a diverse repertoire of internalization mechanisms that operate in parallel with clathrin‐mediated endocytosis.
Andrea Francesco Benvenuto, Amir Fardin, Matteo Balestra, Pier Paolo Di Fiore, Chiara Tordonato, Sara Sigismund   +5 more
wiley   +1 more source

Critical Error Frequency and the Impact of Training with Inhalers Commonly used for Maintenance Treatment in Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2020
David J Collier,1,2 Pascal Wielders,3 Job van der Palen,4,5 Logan Heyes,6 Dawn Midwinter,6 Kathryn Collison,7 Andy Preece,6 Neil Barnes,1,6 Raj Sharma6 1William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen ...
Collier DJ, Wielders P, van der Palen J, Heyes L, Midwinter D, Collison K, Preece A, Barnes N, Sharma R   +8 more
doaj  

Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis

Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.
How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala, Gabriel Eduardo Guzmán‐López, Annia Galano   +2 more
wiley   +1 more source

ARIA‐EAACI 2025: Person‐Centred, Digitally Enabled and Artificial Intelligence‐Assisted Change Management in Airway Diseases

Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.
ABSTRACT Allergic Rhinitis and its Impact on Asthma (ARIA) was, up until 2017, a guideline using the best evidence (Grading of Recommendations, Assessment, Development and Evaluation, GRADE) and developed as a change management strategy. A second change management strategy—in collaboration with the European Academy of Allergy and Clinical Immunology ...
Jean Bousquet, Bernardo Sousa‐Pinto, Mohamed H. Shamji, Maria J. Torres, Ludger Klimek, Holger J. Schünemann, Mario Morais‐Almeida, Rafael José Vieira, Alkis Togias, Boleslaw Samolinski, Arunas Valiulis, Siân Williams, Oliver Pfaar, Torsten Zuberbier, Anna Bedbrook, Wienczyslawa Czarlewski, Maryam Ali Al‐Nesf, Rita Amaral, Josep M. Anto, Antonio Bognanni, Luisa Brussino, Alvaro A. Cruz, Violeta Kvedariene, Habib Douagui, Nikolaos G. Papadopoulos, G. Walter Canonica, Ivan Cherrez‐Ojeda, Mark Dykewicz, Bilun Gemicioglu, Mattia Giovannini, Brigita Gradauskiene, Tari Haahtela, Cristina Jacomelli, Tuomas Jartti, Miloš Jeseňák, Piotr Kuna, Désirée E. Larenas‐Linnemann, Amir H. A. Latiff, Bryan Martin, Yousser Mohammad, Kari Nadeau, Elizabete Nunes, Ken Ohta, Martial Ouédraogo, Padukudru A. Mahesh, Isabella Pali‐Schölll, Ana Margarida Pereira, Frederico S. Regateiro, Nicolas Roche, Mikhail Sofiev, Luis Taborda‐Barata, Charlotte Suppli Ulrik, Sanna K. Toppila‐Salmi, Marylin Valentin Rostan, Leticia de las Vecillas, Maria Teresa Ventura, Giovanni Viegi, De Yun Wang, He Zhang, Luo Zhang, Giorgio Ciprandi, Juan Carlos Ivancevich, Nikolai Khaltaev, Olga Lourenço, Lucas Leemann, Marine Savouré, Juan Jose Yepes‐Nuñez, Arzu Yorgancioglu, Baharudin Abdullah, Mona Al‐Ahmad, Julijana Asllani, Karl‐C. Bergmann, Jonathan A. Bernstein, Michael S. Blaiss, Fulvio Braido, Pedro Carreiro‐Martins, Lorenzo Cecchi, Antonio F. M. Giuliano, George Christoff, Ieva Cirule, Jaime Correia‐de‐Sousa, Elisio M. Costa, Biljana Cvetkovski, Stefano Del Giacco, Philippe Devillier, Dejan Dokic, Maia Gotua, Maria Antonieta Guzman, Elham Hossny, Tomohisa Iinuma, Carla Irani, Zhanat Ispayeva, Kaja Julge, Igor Kaidashev, Kazi S. Bennoor, Helga Kraxner, Inger Kull, Marek Kulus, Maciej Kupczyk, Andriy Kurchenko, Xin Luo, Stefania La Grutta, Lan Le Thi Tuyet, Michael Makris, Branislava Milenkovic, Neven Miculinic, Sang Min Lee, Stephen Montefort, André Moreira, Joaquim Mullol, Rachel Nadif, Alla Nakonechna, Hugo E. Neffen, Stefania Nicola, Marek Niedoszytko, Dieudonné Nyembue, Robyn E. O’Hehir, Ismail Ogulur, Yoshitaka Okamoto, Markus Ollert, Heidi Olze, Oscar Palomares, Petr Panzner, Hae‐Sim Park, Vincenzo Patella, Ruby Pawankar, Constantinos Pitsios, Todor A. Popov, Francesca Puggioni, Santiago Quirce, Agné Ramonaité, Marysia Recto, Maria Susana Repka‐Ramirez, Karla Robles‐Velasco, Menachem Rottem, Marianella Salapatas, Joaquin Sastre, Nicola Scichilone, Juan‐Carlos Sisul, Dirceu Solé, Manuel Soto‐Martinez, Milan Sova, Katarina Stevanovic, Pongsakorn Tantilipikorn, Ana Todo‐Bom, Vladyslav Tsaryk, Ioanna Tsiligianni, Marilyn Urrutia‐Pereira, Erkka Valovirta, Tuula Vasankari, Dana Wallace, Margitta Worm, Osman M. Yusuf, Fares Zaitoun, Mihaela Zidarn, on behalf of ARIA study group   +155 more
wiley   +1 more source