Results 261 to 270 of about 470,220 (291)
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Annual Review of Neuroscience, 1995
It is widely assumed that long-term changes in synaptic strength underlie information storage in the brain and, ultimately, behavioral memory. Recent years have seen a major effort to identify and analyze electrophysiological model systems in which particular patterns of neural activity give rise to such enduring changes.
David J. Linden, John A. Connor
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It is widely assumed that long-term changes in synaptic strength underlie information storage in the brain and, ultimately, behavioral memory. Recent years have seen a major effort to identify and analyze electrophysiological model systems in which particular patterns of neural activity give rise to such enduring changes.
David J. Linden, John A. Connor
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Long-term management of depression
The American Journal of Medicine, 1994Major depression is often a chronic and recurrent disorder. Findings from a landmark study, the Pittsburgh Study of Maintenance Therapies in Recurrent Depression, demonstrate that full doses of antidepressants prevent recurrent depression and that maintenance therapy lasting at least 5 years may be required for patients with severely recurrent disease.
Robert M. A. Hirschfeld +3 more
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Journal of the American Medical Directors Association, 2008
To review the diagnosis and treatment of depressive disorders in long-term care settings.A review of the literature on the diagnosis and treatment of depression in long-term care.Up to 35% of residents in long-term care facilities may experience either major depression or clinically significant depressive symptoms.
Mugdha Thakur, Dan G. Blazer
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To review the diagnosis and treatment of depressive disorders in long-term care settings.A review of the literature on the diagnosis and treatment of depression in long-term care.Up to 35% of residents in long-term care facilities may experience either major depression or clinically significant depressive symptoms.
Mugdha Thakur, Dan G. Blazer
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Long-term treatment of depression
European Neuropsychopharmacology, 1994In the late 1800's Kraepelin hypothesized that depression had a high probability for recovery. He described depression as acute episodes from which the patient returned to premorbid state of "well-being". It was postulated that there were subgroups who had a recurrent course, but the emphasis was on the theory that between episodes of depression ...
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Long-term depression with a flash [PDF]
Nature Neuroscience, 1998 The site of expression of hippocampal synaptic plasticity has been hotly debated. A new study demonstrates that postsynaptic neurons alone can express long-term depression.
Robert C. Malenka, Roger A. Nicoll
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Clinical Psychology: Science and Practice, 2005
The assessment and treatment of depression in long-term care (LTC) settings poses unique challenges to both clinicians and researchers. In this review we discuss the variety of forms depression can take among LTC residents and the influence the LTC environment can play on the development and maintenance of depression.
Lee Hyer +3 more
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The assessment and treatment of depression in long-term care (LTC) settings poses unique challenges to both clinicians and researchers. In this review we discuss the variety of forms depression can take among LTC residents and the influence the LTC environment can play on the development and maintenance of depression.
Lee Hyer +3 more
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Annual Review of Neuroscience, 1989
LTD has now been established as a synaptic plasticity specific to the cerebellum. Cellular and molecular mechanisms of LTD have been elucidated to some extent, but still a number of questions are left open. The most crucial question may concern its time course, as to how long the LTD lasts beyond the limit of the present maximum observation time of 3 ...
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LTD has now been established as a synaptic plasticity specific to the cerebellum. Cellular and molecular mechanisms of LTD have been elucidated to some extent, but still a number of questions are left open. The most crucial question may concern its time course, as to how long the LTD lasts beyond the limit of the present maximum observation time of 3 ...
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A model for long-term potentiation and depression
Journal of Computational Neuroscience, 1995A computational model of long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus is presented. The model assumes the existence of retrograde signals, is in good agreement with several experimental data on LTP, LTD, and their pharmacological manipulations, and shows how a simple kinetic scheme can capture the essential ...
Migliore, M, Alicata, F, Ayala, GF
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The long-term management of depression
Journal of Psychopharmacology, 1995The long-term outlook for patients with unipolar depression is often poor. As few as one-fifth will remain well and a similar number will suffer chronic depression. It is now standard practice to extend acute treatment into a 4–6 month period of continuation therapy, and the value of prophylactic treatment over longer periods is becoming more widely ...
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Calcium signals in long-term potentiation and long-term depression
Canadian Journal of Physiology and Pharmacology, 1999We describe postsynaptic Ca2+signals that subserve induction of two forms of neuronal plasticity, long-term potentiation (LTP) and long-term depression (LTD), in rat hippocampal neurons. The common induction protocol for LTP, a 1-s, 50-Hz tetanus, generates Ca2+increases of about 50 µM in dendritic spines of CA1 neurons.
Satoru Otani +3 more
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