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Model for the role of hsa_circ_0026782/p‐CREB1 (Ser142) played in keloid. Hsa_circ_0026782 is derived from back‐splicing of ITGA7 exon 4. When hsa_circ_0026782 binds to CREB1, the exposure of the bZIP domain and dimerization of CREB1 are promoted (upper left).
Xin‐Cao Zhong+10 more
wiley +1 more source
This study focuses on the functionalization of PEDOT:PSS with substituted azobenzenes as gate electrodes and the investigation of the relationship between molecular structure and optoelectronic performance in organic photoelectrochemical transistors (OPECTs).
Isabela Berndt Paro+16 more
wiley +1 more source
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Long-term depression in the CNS
Nature Reviews Neuroscience, 2010Long-term depression (LTD) in the CNS has been the subject of intense investigation as a process that may be involved in learning and memory and in various pathological conditions. Several mechanistically distinct forms of this type of synaptic plasticity have been identified and their molecular mechanisms are starting to be unravelled.
G. Collingridge+3 more
semanticscholar +4 more sources
Annual Review of Neuroscience, 1989
LTD has now been established as a synaptic plasticity specific to the cerebellum. Cellular and molecular mechanisms of LTD have been elucidated to some extent, but still a number of questions are left open. The most crucial question may concern its time course, as to how long the LTD lasts beyond the limit of the present maximum observation time of 3 ...
Masao Ito
semanticscholar +3 more sources
LTD has now been established as a synaptic plasticity specific to the cerebellum. Cellular and molecular mechanisms of LTD have been elucidated to some extent, but still a number of questions are left open. The most crucial question may concern its time course, as to how long the LTD lasts beyond the limit of the present maximum observation time of 3 ...
Masao Ito
semanticscholar +3 more sources
Long-Term Depression in Hippocampus
Annual Review of Neuroscience, 1996Long-term depression (LTD) is a lasting decrease in synaptic effectiveness that follows some types of electrical stimulation in the hippocampus. Two broad types of LTD may be distinguished. Heterosynaptic LTD can occur at synapses that are inactive, normally during high-frequency stimulation of a converging synaptic input.
Wickliffe C. Abraham, Mark F. Bear
openaire +3 more sources
Annual Review of Neuroscience, 1995
It is widely assumed that long-term changes in synaptic strength underlie information storage in the brain and, ultimately, behavioral memory. Recent years have seen a major effort to identify and analyze electrophysiological model systems in which particular patterns of neural activity give rise to such enduring changes.
David J. Linden, John A. Connor
openaire +3 more sources
It is widely assumed that long-term changes in synaptic strength underlie information storage in the brain and, ultimately, behavioral memory. Recent years have seen a major effort to identify and analyze electrophysiological model systems in which particular patterns of neural activity give rise to such enduring changes.
David J. Linden, John A. Connor
openaire +3 more sources
Long-term management of depression
The American Journal of Medicine, 1994Major depression is often a chronic and recurrent disorder. Findings from a landmark study, the Pittsburgh Study of Maintenance Therapies in Recurrent Depression, demonstrate that full doses of antidepressants prevent recurrent depression and that maintenance therapy lasting at least 5 years may be required for patients with severely recurrent disease.
Robert M. A. Hirschfeld+3 more
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Journal of the American Medical Directors Association, 2008
To review the diagnosis and treatment of depressive disorders in long-term care settings.A review of the literature on the diagnosis and treatment of depression in long-term care.Up to 35% of residents in long-term care facilities may experience either major depression or clinically significant depressive symptoms.
Mugdha Thakur, Dan G. Blazer
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To review the diagnosis and treatment of depressive disorders in long-term care settings.A review of the literature on the diagnosis and treatment of depression in long-term care.Up to 35% of residents in long-term care facilities may experience either major depression or clinically significant depressive symptoms.
Mugdha Thakur, Dan G. Blazer
openaire +3 more sources
Long-term treatment of depression
European Neuropsychopharmacology, 1994In the late 1800's Kraepelin hypothesized that depression had a high probability for recovery. He described depression as acute episodes from which the patient returned to premorbid state of "well-being". It was postulated that there were subgroups who had a recurrent course, but the emphasis was on the theory that between episodes of depression ...
openaire +6 more sources
Clinical Psychology: Science and Practice, 2005
The assessment and treatment of depression in long-term care (LTC) settings poses unique challenges to both clinicians and researchers. In this review we discuss the variety of forms depression can take among LTC residents and the influence the LTC environment can play on the development and maintenance of depression.
Lee Hyer+3 more
openaire +2 more sources
The assessment and treatment of depression in long-term care (LTC) settings poses unique challenges to both clinicians and researchers. In this review we discuss the variety of forms depression can take among LTC residents and the influence the LTC environment can play on the development and maintenance of depression.
Lee Hyer+3 more
openaire +2 more sources