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Long-term depression with a flash [PDF]
Nature Neuroscience, 1998 The site of expression of hippocampal synaptic plasticity has been hotly debated. A new study demonstrates that postsynaptic neurons alone can express long-term depression.
Robert C. Malenka, Roger A. Nicoll
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A model for long-term potentiation and depression
Journal of Computational Neuroscience, 1995A computational model of long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus is presented. The model assumes the existence of retrograde signals, is in good agreement with several experimental data on LTP, LTD, and their pharmacological manipulations, and shows how a simple kinetic scheme can capture the essential ...
Migliore, M, Alicata, F, Ayala, GF
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The long-term management of depression
Journal of Psychopharmacology, 1995The long-term outlook for patients with unipolar depression is often poor. As few as one-fifth will remain well and a similar number will suffer chronic depression. It is now standard practice to extend acute treatment into a 4–6 month period of continuation therapy, and the value of prophylactic treatment over longer periods is becoming more widely ...
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Calcium signals in long-term potentiation and long-term depression
Canadian Journal of Physiology and Pharmacology, 1999We describe postsynaptic Ca2+signals that subserve induction of two forms of neuronal plasticity, long-term potentiation (LTP) and long-term depression (LTD), in rat hippocampal neurons. The common induction protocol for LTP, a 1-s, 50-Hz tetanus, generates Ca2+increases of about 50 µM in dendritic spines of CA1 neurons.
Satoru Otani +3 more
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Long‐term treatment of depression with isocarboxazide
Acta Psychiatrica Scandinavica, 1980Isocarboxazide has been used as long‐term treatment for a selected group of 20 depressive patients, of whom some 90% (17/19) were non‐responders to treatment with tricyclic antidepressants. At the follow‐up the median duration of illness was 162 months, and the median duration of treatment was 42 months. Side‐effects and interactions were moderate thus
J. K. Larsen, O. J. Rafaelsen
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Depression: A Long-Term Illness
British Journal of Psychiatry, 1994The realisation that major depression is often both chronic and recurrent has slowly begun to change the way that depression is diagnosed and treated. In particular, the need for continuation and maintenance treatment is an issue that now deserves increased attention, especially with the availability of new classes of antidepressant treatments, which ...
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Long-Term Potentiation and Long-Term Depression
2018Synaptic connections in the brain can change their strength in response to patterned activity. This ability of synapses is defined as synaptic plasticity. Long lasting forms of synaptic plasticity, long-term potentiation (LTP), and long-term depression (LTD), are thought to mediate the storage of information about stimuli or features of stimuli in a ...
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The Long-Term Outcome of Depressive Illness
British Journal of Psychiatry, 1988One hundred and forty-five patients with primary depressive illness admitted to a university hospital between 1966 and 1970 were followed up an average of 15 years later. Adequate data were obtained on 133 (92%) of the 145. During the follow-up period, 7% of the 133 had suicided, 12% had remained incapacitated by illness and only 20% had remained ...
Gavin Andrews +2 more
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Long-Term Depression: Cerebellum
2001Long-term depression (LTD) displayed in the cerebellar cortex is a persistent decrease of the transmission efficacy from granule cell to Purkinje cells. LTD is induced when two inputs to a Purkinje cell, one from a climbing fiber and the other from a set of granule cell axons, are repeatedly associated.
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Long-Term Potentiation, Long-Term Depression, and Learning
1998Publisher Summary Almost everyone agrees that information is acquired, stored, and retrieved by the brain. All brains consist of individual cellular elements. Most neurons have the same parts: a dendritic tree, cell body, axon, and synaptic boutons.
Joe L. Martinez +2 more
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