Results 371 to 380 of about 4,254,343 (401)
Some of the next articles are maybe not open access.
Depression: A Long-Term Illness
British Journal of Psychiatry, 1994The realisation that major depression is often both chronic and recurrent has slowly begun to change the way that depression is diagnosed and treated. In particular, the need for continuation and maintenance treatment is an issue that now deserves increased attention, especially with the availability of new classes of antidepressant treatments, which ...
openaire +3 more sources
Depression in the long-term course of schizophrenia
European Archives of Psychiatry and Clinical Neuroscience, 2005Depressive symptoms are quantitatively and qualitatively among the most important characteristics of schizophrenia. The following contribution reports on the prevalence of depression in 107 patients of the ABC schizophrenia study over 12 years after first hospital admission, looks into a preponderance of depression at certain stages of the illness and ...
Wolfram an der Heiden +4 more
openaire +3 more sources
Long-Term Potentiation and Long-Term Depression
2018Synaptic connections in the brain can change their strength in response to patterned activity. This ability of synapses is defined as synaptic plasticity. Long lasting forms of synaptic plasticity, long-term potentiation (LTP), and long-term depression (LTD), are thought to mediate the storage of information about stimuli or features of stimuli in a ...
openaire +2 more sources
The Long-Term Outcome of Depressive Illness
British Journal of Psychiatry, 1988One hundred and forty-five patients with primary depressive illness admitted to a university hospital between 1966 and 1970 were followed up an average of 15 years later. Adequate data were obtained on 133 (92%) of the 145. During the follow-up period, 7% of the 133 had suicided, 12% had remained incapacitated by illness and only 20% had remained ...
Gavin Andrews +2 more
openaire +3 more sources
Long-Term Depression: Cerebellum
2001Long-term depression (LTD) displayed in the cerebellar cortex is a persistent decrease of the transmission efficacy from granule cell to Purkinje cells. LTD is induced when two inputs to a Purkinje cell, one from a climbing fiber and the other from a set of granule cell axons, are repeatedly associated.
openaire +2 more sources
Long-Term Potentiation, Long-Term Depression, and Learning
1998Publisher Summary Almost everyone agrees that information is acquired, stored, and retrieved by the brain. All brains consist of individual cellular elements. Most neurons have the same parts: a dendritic tree, cell body, axon, and synaptic boutons.
Joe L. Martinez +2 more
openaire +2 more sources
The Long-Term Outcome of Maudsley Depressives
British Journal of Psychiatry, 1988Eighty-nine consecutive admissions with primary depressive illness were prospectively ascertained and diagnosed in 1965–66 by R. E. Kendell, who also allocated each a position on a neurotic-psychotic continuum on the basis of previous discriminant function analysis. In 1983–84, 94% of the survivors were personally interviewed by a psychiatrist blind to
Robin M. Murray, Alan S. Lee
openaire +2 more sources
Heterosynaptic long-term depression in the hippocampus
Journal of Physiology-Paris, 1996Heterosynaptic long-term depression (hetLTD) at one input can be induced by applying a conditioning stimulus to an adjacent set of synapses. In hippocampal CA1 pyramidal cells, our results suggest that hetLTD is triggered by an extracellular diffusible factor that is released following tetanic activation of NMDA receptors.
Robert C. Malenka +2 more
openaire +3 more sources
The long-term stability of depressive subtypes
American Journal of Psychiatry, 1994This study used the concept of diagnostic stability to examine the validity of three subtypes of major depression.Patients with major depressive disorder (N = 424) were assigned baseline diagnoses according to structured interviews and the Research Diagnostic Criteria.
Traae Shea +5 more
openaire +2 more sources
An essential role for protein phosphatases in hippocampal long-term depression.
Science, 1993The effectiveness of long-term potentiation (LTP) as a mechanism for information storage would be severely limited if processes that decrease synaptic strength did not also exist.
R. Mulkey, C. Herron, R. Malenka
semanticscholar +1 more source