Results 41 to 50 of about 4,459,968 (325)

Aging, Cognitive Decline and Hearing Loss: Effects of Auditory Rehabilitation and Training with Hearing Aids and Cochlear Implants on Cognitive Function and Depression among Older Adults [PDF]

, 2016
A growing interest in cognitive effects associated with speech and hearing processes is spreading throughout the scientific community essentially guided by evidence that central and peripheral hearing loss is associated with cognitive decline.
Benatti, Alice, Bovo, Roberto, Castiglione, Alessandro, Favaro, Diego, Gabelli, Carlo, Martini, Alessandro, Padoan, Elisa, Pagliaro, Michela, Severi, Daniele, Vallesi, Antonino, Velardita, Carmelita   +10 more
core   +1 more source

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

Philosophical Transactions of the Royal Society B: Biological Sciences, 2014
The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is
Tetsuya Kimura, Daniel J. Whitcomb, J. Jo, P. Regan, T. Piers, S. Heo, Christopher Brown, T. Hashikawa, M. Murayama, H. Seok, I. Sotiropoulos, Eunjoon Kim, G. Collingridge, A. Takashima, Kwangwook Cho   +14 more
semanticscholar   +1 more source

Psychotherapies for depression: a network meta‐analysis covering efficacy, acceptability and long‐term outcomes of all main treatment types

World Psychiatry, 2021
The effects of psychotherapies for depression have been examined in several hundreds of randomized trials, but no recent network meta‐analysis (NMA) has integrated the results of these studies.
P. Cuijpers, S. Quero, H. Noma, Marketa Ciharova, Clara Miguel, E. Karyotaki, A. Cipriani, I. Cristea, T. Furukawa   +8 more
semanticscholar   +1 more source

Motor cortical plasticity induced by motor learning through mental practice.

Frontiers in Behavioral Neuroscience, 2015
Several investigations suggest that actual and mental actions trigger similar neural substrates. Motor learning via physical practice results in long-term potentiation (LTP)-like plasticity processes, namely potentiation of M1 and a temporary occlusion ...
Laura eAvanzino, Nicolas eGueugneau, Ambra eBisio, Piero eRuggeri, Charalambos ePAPAXANTHIS, Marco eBove   +5 more
doaj   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

The demise of the synapse as the locus of memory: A looming paradigm shift?

Frontiers in Systems Neuroscience, 2016
Synaptic plasticity is widely considered to be the neurobiological basis of learning and memory by neuroscientists and researchers in adjacent fields, though diverging opinions are increasingly being recognised. From the perspective of what we might call
Patrick C. Trettenbrein, Patrick C. Trettenbrein   +1 more
doaj   +1 more source

Spike timing dependent plasticity: a consequence of more fundamental learning rules

Frontiers in Computational Neuroscience, 2010
Spike timing dependent plasticity (STDP) is a phenomenon in which the precise timing of spikes affects the sign and magnitude of changes in synaptic strength.
Harel Z Shouval, Samuel S. -H Wang, Gayle M Wittenberg   +2 more
doaj   +1 more source

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome [PDF]

, 2012
Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the fragile X mental retardation protein, which regulates signal transduction at metabotropic glutamate receptor-5 in the brain.
DiPatrizio, Nicholas V., Frick, Andreas, Ginger, Melanie, Henstridge, Christopher M., Jung, Kwang-Mook, Katona, Istvan, Lassalle, Olivier, Mackie, Ken, Manzoni, Olivier J., Martin, Henry, Neuhofer, Daniela, Piomelli, Daniele, Sepers, Marja   +12 more
core   +5 more sources

mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo

Nature Communications, 2014
NMDA-type glutamate receptors (NMDARs) are currently regarded as paramount in the potent and selective disruption of synaptic plasticity by Alzheimer’s disease amyloid β-protein (Aβ). Non-NMDAR mechanisms remain relatively unexplored.
Neng-Wei Hu, Andrew J. Nicoll, Dainan Zhang, Alexandra J Mably, Tiernan T O'Malley, Silvia A. Purro, C. Terry, J. Collinge, D. Walsh, M. Rowan   +9 more
semanticscholar   +1 more source

Non-Hebbian Spike-Timing Dependent Plasticity in Cerebellar Circuits

Frontiers in Neural Circuits, 2013
Spike-timing dependent plasticity (STDP) provides a cellular implementation of the Hebb postulate, which states that synapses, whose activity repeatedly drives action potential firing in target cells, are potentiated.
Claire ePiochon, Peter eKruskal, Jason N MacLean, Christian eHansel   +3 more
doaj   +1 more source