Results 191 to 200 of about 80,960 (256)

Retinomorphic Visual Processing Enabled by Contact‐Engineered IGZO Optoelectronic Synaptic Memtransistors

Advanced Science, EarlyView.
Here, we present an optoelectronic synaptic memtransistor (OSMT) integrating photoresponsive IGZO with contact‐engineered HfO2, enabling electrically and optically tunable synaptic weights. The device demonstrates broad range of tunable conductance states and array‐level image processing, highlighting its potential for intelligent machine vision ...
Donghyun Kang, San Nam, Dayul Nam, In‐Soo Kim, Myung‐Gil Kim, Sung Kyu Park, Yong‐Hoon Kim   +6 more
wiley   +1 more source

Cortical nitric oxide required for presynaptic long-term potentiation in the insular cortex. [PDF]

Philos Trans R Soc Lond B Biol Sci
Yamamoto K, Chen QY, Zhou Z, Kobayashi M, Zhuo M.   +4 more
europepmc   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

The role of calcium stores in long-term potentiation and synaptic tagging and capture in mouse hippocampus. [PDF]

Philos Trans R Soc Lond B Biol Sci
Koek LA, Sanderson TM, Georgiou J, Collingridge GL.   +3 more
europepmc   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations. [PDF]

Philos Trans R Soc Lond B Biol Sci
Hagena H, Manahan-Vaughan D.
europepmc   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Rapid and local neuroestrogen synthesis supports long-term potentiation of hippocampal Schaffer collaterals-cornu ammonis 1 synapse in ovariectomized mice. [PDF]

J Neuroendocrinol
Maroteaux MJ, Noccioli CT, Daniel JM, Schrader LA.   +3 more
europepmc   +1 more source

Interference with glutamate antiporter system x_c ^- enables post-hypoxic long-term potentiation in hippocampus. [PDF]

Exp Physiol
Heit BS, Chu A, McRay A, Richmond JE, Heckman CJ, Larson J.   +5 more
europepmc   +1 more source

Developmental ethanol exposure produces deficits in long-term potentiation in vivo that persist following postnatal choline supplementation. [PDF]

Alcohol Clin Exp Res (Hoboken)
Titterness AK, Gräfe EL, Acosta C, Rodriguez C, Thomas JD, Christie BR.   +5 more
europepmc   +1 more source