Results 191 to 200 of about 80,675 (256)

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Rapid and local neuroestrogen synthesis supports long-term potentiation of hippocampal Schaffer collaterals-cornu ammonis 1 synapse in ovariectomized mice. [PDF]

J Neuroendocrinol
Maroteaux MJ, Noccioli CT, Daniel JM, Schrader LA.   +3 more
europepmc   +1 more source

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu, Zhenguo Liu, Lizhen Jiang, Andong Huang, Xinqing Lin, Xinyue Li, Bingyuan Liu, Shiwen Hu, Qiang Pan, Junjun Huang, Liyuan Yin, Liling Jiang, Wei Yi, Wenjun Mao, Yueyuan Zheng, Xianping Shi   +15 more
wiley   +1 more source

Interference with glutamate antiporter system x_c ^- enables post-hypoxic long-term potentiation in hippocampus. [PDF]

Exp Physiol
Heit BS, Chu A, McRay A, Richmond JE, Heckman CJ, Larson J.   +5 more
europepmc   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Developmental ethanol exposure produces deficits in long-term potentiation in vivo that persist following postnatal choline supplementation. [PDF]

Alcohol Clin Exp Res (Hoboken)
Titterness AK, Gräfe EL, Acosta C, Rodriguez C, Thomas JD, Christie BR.   +5 more
europepmc   +1 more source

Median raphe glutamatergic neuron-mediated enhancement of GABAergic transmission and suppression of long-term potentiation in the hippocampus. [PDF]

Heliyon
Stinson HE, Ninan I.
europepmc   +1 more source

Ventral tegmental area dopamine projections to the hippocampus trigger long-term potentiation and contextual learning. [PDF]

Nat Commun
Sayegh FJP, Mouledous L, Macri C, Pi Macedo J, Lejards C, Rampon C, Verret L, Dahan L.   +7 more
europepmc   +1 more source

Reflecting on 50 years of long-term potentiation: Insights from the Royal Society's LTP50 conference. [PDF]

Brain Neurosci Adv
Mitchell-Heggs R, Tse D.
europepmc   +1 more source

Impaired Hippocampal Long-Term Potentiation and Memory Deficits upon Haploinsufficiency of MDGA1 Can Be Rescued by Acute Administration of D-Cycloserine. [PDF]

Int J Mol Sci
Ojima D, Tominaga Y, Kubota T, Tada A, Takahashi H, Kishimoto Y, Tominaga T, Yamamoto T.   +7 more
europepmc   +1 more source