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The discovery of long-term potentiation [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2003
Abstract This paper describes circumstances around the discovery of long-term potentiation (LTP). In 1966, I had just begun independent work for the degree of Dr medicinae (PhD) in Per Andersen’s laboratory in Oslo after an eighteen-month apprenticeship with him. Studying the effects of activating the perforant path to dentate granule
Terje Lømo
exaly   +3 more sources

Long-term potentiation and memory [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2003
Abstract The discovery of long-term potentiation (LTP) transformed research on the neurobiology of learning and memory. This did not happen overnight, but the discovery of an experimentally demonstrable phenomenon reflecting activity-driven neuronal and synaptic plasticity changed discussions about what might underlie learning from ...
Richard G M Morris
exaly   +3 more sources

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Long-Term Potentiation

Annual Review of Neuroscience, 1987
History and Definition In 1973, two reports appeared in the Journal of Physiology that described a long-term potentiation (L TP) of synaptic transmission at a monosynaptic junction in the mammalian eNS. These two papers, one dealing with the anesthetized rabbit preparation (Bliss & L0mo 1973) and the other dealing with the unanesthetized rabbit (Bliss &
T J, Teyler, P, DiScenna
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Long-Term Synaptic Potentiation

Science, 1988
Long-term synaptic potentiation (LTP) is a leading candidate for a synaptic mechanism of rapid learning in mammals. LTP is a persistent increase in synaptic efficacy that can be quickly induced. The biophysical process that controls one type of LTP is formally similar to a synaptic memory mechanism postulated decades ago by the ...
T H, Brown, P F, Chapman, E W, Kairiss, C L, Keenan   +3 more
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Neocortical long-term potentiation

Current Opinion in Neurobiology, 1993
LTP is a form of activity-dependent synaptic plasticity that has been investigated mainly in the hippocampus. It is considered likely that similar mechanisms may also account for aspects of naturally occurring plasticity in the neocortex. Consequently, an increasing number of studies have been devoted to the investigation of neocortical LTP.
M F, Bear, A, Kirkwood
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Pharmacology of long-term potentiation.

Folia Pharmacologica Japonica, 1993
The physiological characteristics and significance of long-term potentiation in the hippocampus were summarized. In particular, it was pointed out that different mechanisms are involved in the production of hippocampal LTP between the mossy fiber-CA3 system and other systems such as Schaffer collateral-CA1, fimbrial fiber-CA3 and commissural ...
M, Satoh, S, Watanabe
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LONG-TERM POTENTIATION AND LEARNING

Annual Review of Psychology, 1996
▪ Abstract  Long-term potentiation (LTP), a relatively long-lived increase in synaptic strength, remains the most popular model for the cellular process that may underlie information storage within neural systems. The strongest arguments for a role of LTP in memory are theoretical and involve Hebb's Postulate, Marr's theory of hippocampal function, and
J L, Martinez, B E, Derrick
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The long-term potential of LTP

Nature Reviews Neuroscience, 2003
Long-term potentiation has captured the attention of neuroscientists for over two decades. It has provided motivation to investigate the detailed mechanisms of synaptic transmission and remains a prime candidate for mediating circuit modifications during development and experience-dependent plasticity.
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A model for long-term potentiation and depression

Journal of Computational Neuroscience, 1995
A computational model of long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus is presented. The model assumes the existence of retrograde signals, is in good agreement with several experimental data on LTP, LTD, and their pharmacological manipulations, and shows how a simple kinetic scheme can capture the essential ...
Migliore, M, Alicata, F, Ayala, GF
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