Results 221 to 230 of about 3,183,091 (359)

The SNARE protein Ykt6 drives insertion of the GluA1 and GluA2 glutamate receptors at synaptic spines during long-term potentiation. [PDF]

J Biol Chem
Takahashi M, Raman M, Caraveo G.
europepmc   +1 more source

Zinc enhances hippocampal long-term potentiation at CA1 synapses through NR2B containing NMDA receptors

, 2018
John Sullivan, Xiaolei Zhang, Arthur P. Sullivan, Linnea R. Vose, Alexander A. Moghadam, Victor A. Fried, Patric K. Stanton   +6 more
openalex   +2 more sources

Activity Pattern-Dependent Long-Term Potentiation in Neocortex and Hippocampus of GluA1 (GluR-A) Subunit-Deficient Mice [PDF]

, 2009
Marco C. Frey, Rolf Sprengel, Thomas Nevian   +2 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Lysine myristoylation mediates long-term potentiation via membrane enrichment of synaptic plasticity effectors. [PDF]

EMBO J
Matthews B, Steeves SA, Akefe IO, Ahmed NY, Gormal RS, Dehorter N, Wallis TP, Meunier FA.   +7 more
europepmc   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Agmatine decreases long-term potentiation <i>via</i> α2-adrenergic receptor and imidazoline type 1 receptor in the hippocampus. [PDF]

Korean J Physiol Pharmacol
Chang W, An J, Jang SH, Kim M, Min SS.
europepmc   +1 more source

Current Studies on a Working Model of CaM Kinase II in Hippocampal Long-Term Potentiation and Memory

, 1999
Kohji Fukunaga, Miyamoto Eishichi
openalex   +1 more source

Perceptual Correlates of Nociceptive Long-Term Potentiation and Long-Term Depression in Humans [PDF]

, 2004
Thomas Klein, Walter Magerl, H. Hopf, Jürgen Sandkühler, Rolf‐Detlef Treede   +4 more
openalex   +1 more source

NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer

Advanced Science, EarlyView.
This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang, Qingling Zhang, Yuhan Zhang, Xinlu Yu, Bo Jia, Yulong Dong, Yalong Wu, Kelong Fan, Xinquan Gu, Lei Ji, Wei Jiang, Bin Liu   +11 more
wiley   +1 more source