Results 41 to 50 of about 3,183,091 (359)
, 2016 Synaptic memory is considered to be the main element responsible for learning and cognition in humans. Although traditionally non-volatile long-term plasticity changes have been implemented in nanoelectronic synapses for neuromorphic applications, recent
Roy, Kaushik, Sengupta, Abhronil
core +1 more source
Age-dependent loss of PTP and LTP in the hippocampus of PrP-null mice
Neurobiology of Disease, 2003 We have investigated synaptic function in the hippocampus in mice of different ages carrying a null mutation in the PrP gene. Experiments carried out in vivo and in vitro in two laboratories revealed no differences in the ability of juvenile and young ...
John Curtis +4 more
doaj +1 more source
, 2013 Synfire chains are thought to underlie precisely-timed sequences of spikes observed in various brain regions and across species. How they are formed is not understood. Here we analyze self-organization of synfire chains through the spike-timing dependent
Jin, Dezhe Z., Miller, Aaron
core +1 more source
Emulating long-term synaptic dynamics with memristive devices [PDF]
, 2016 The potential of memristive devices is often seeing in implementing neuromorphic architectures for achieving brain-like computation. However, the designing procedures do not allow for extended manipulation of the material, unlike CMOS technology, the ...
Berdan, Radu +5 more
core +2 more sources
Frontiers in Systems Neuroscience, 2019 Norepinephrine (NE) in dentate gyrus (DG) produces NE-dependent long-term potentiation (NE-LTP) of the perforant path-evoked potential population spike both in vitro and in vivo. Chemical activators infused near locus coeruleus (LC), the source of DG NE,
Meghan A. L. Quinlan +5 more
doaj +1 more source
Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]
, 2004 Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release.
Scheler, Gabriele
core +1 more source
Long-term potentiation in the hippocampus: discovery, mechanisms and function
Neuroforum, 2018 In this review we reflect upon our contributions to the study of the properties and mechanisms of long-term potentiation (LTP) and describe some of the major influences on our work. We then go on to consider whether LTP has fulfilled its early promise of
T. Bliss +3 more
semanticscholar +1 more source
Convergent evidence for abnormal striatal synaptic plasticity in dystonia
Neurobiology of Disease, 2010 Dystonia is a functionally disabling movement disorder characterized by abnormal movements and postures. Although substantial recent progress has been made in identifying genetic factors, the pathophysiology of the disease remains a mystery.
David A. Peterson +2 more
doaj +1 more source
Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus [PDF]
, 2016 Two forms of NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) at hippocampal CA1 synapses can be distinguished based on their sensitivity to inhibitors of protein kinase A (PKA).
Amici, Mascia +7 more
core +2 more sources
Persistent memories of long-term potentiation and the N-methyl-d-aspartate receptor
Brain and Neuroscience Advances, 2019 In this article, we describe our involvement in the early days of research into long-term potentiation. We start with a description of the early experiments conducted in Oslo and London where long-term potentiation was first characterised. We discuss the
T. Bliss, G. Collingridge
semanticscholar +1 more source