Results 41 to 50 of about 3,075,584 (328)
Philosophical Transactions of the Royal Society B: Biological Sciences, 2017 Synapses are complex because they perform multiple functions, including at least six mechanistically different forms of plasticity. Here, I comment on recent developments regarding these processes.
J. Lisman
semanticscholar +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
5-HT6 Receptors Sex-Dependently Modulate Hippocampal Synaptic Activity through GABA Inhibition
Biomolecules, 2023 The subtype 6 of the serotoninergic receptors (5-HT6Rs) is highly expressed in the hippocampus, and evidence indicates the beneficial effects of 5-HT6Rs blockade on short- and long-term memory in rodents.
Caroline Lahogue +3 more
doaj +1 more source
Beyond Near- and Long-Term: Towards a Clearer Account of Research Priorities in AI Ethics and Society [PDF]
arXiv, 2020 One way of carving up the broad "AI ethics and society" research space that has emerged in recent years is to distinguish between "near-term" and "long-term" research. While such ways of breaking down the research space can be useful, we put forward several concerns about the near/long-term distinction gaining too much prominence in how research ...
arxiv
Isospectral partners for a complex PT-invariant potential [PDF]
, 2002 We construct isospectral partner potentials of a complex PT-invariant potential, viz., V(x) = V_1 sech ^2 x - i V_2 sech x tanh x using Darboux's method. Oneset of isospectral potentials are obatined which can be termed 'Satellite potentials', in the sense that they are pf the same form as the original potential.
arxiv +1 more source
Persistent memories of long-term potentiation and the N-methyl-d-aspartate receptor
Brain and Neuroscience Advances, 2019 In this article, we describe our involvement in the early days of research into long-term potentiation. We start with a description of the early experiments conducted in Oslo and London where long-term potentiation was first characterised. We discuss the
T. Bliss, G. Collingridge
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Frontiers in Systems Neuroscience, 2019 Norepinephrine (NE) in dentate gyrus (DG) produces NE-dependent long-term potentiation (NE-LTP) of the perforant path-evoked potential population spike both in vitro and in vivo. Chemical activators infused near locus coeruleus (LC), the source of DG NE,
Meghan A. L. Quinlan +5 more
doaj +1 more source
Cells, 2022 Maternal hyperhomocysteinemia (HCY) is a common pregnancy complication caused by high levels of the homocysteine in maternal and fetal blood, which leads to the alterations of the cognitive functions, including learning and memory.
Tatyana Y. Postnikova +9 more
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NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).
Cold Spring Harbor Perspectives in Biology, 2012 Long-term potentiation and long-term depression (LTP/LTD) can be elicited by activating N-methyl-d-aspartate (NMDA)-type glutamate receptors, typically by the coincident activity of pre- and postsynaptic neurons.
C. Lüscher, R. Malenka
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