Results 11 to 20 of about 16,187 (162)

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Hypomethylation of LINE-1 repeat elements and global loss of DNA hydroxymethylation in vapers and smokers

Epigenetics, 2020
The outbreak of vaping-related severe lung injuries and deaths and the epidemic of teen vaping in the U.S. underscore the urgent need for determining the biological consequences of electronic cigarette (e-cig) use.
Andrew W. Caliri, Amanda Caceres, Stella Tommasi, Ahmad Besaratinia   +3 more
doaj   +1 more source

Characterizing Repeats in Two Whole-Genome Amplification Methods in the Reniform Nematode Genome

International Journal of Genomics, 2021
One of the major problems in the U.S. and global cotton production is the damage caused by the reniform nematode, Rotylenchulus reniformis. Amplification of DNA from single nematodes for further molecular analysis can be challenging sometimes.
S. T. Nyaku, V. R. Sripathi, K. Lawrence, G. Sharma   +3 more
doaj   +1 more source

LINE-1 hypomethylation during primary colon cancer progression. [PDF]

PLoS ONE, 2011
BACKGROUND: Methylation levels of genomic repeats such as long interspersed nucleotide elements (LINE-1) are representative of global methylation status and play an important role in maintenance of genomic stability.
Eiji Sunami, Michiel de Maat, Anna Vu, Roderick R Turner, Dave S B Hoon   +4 more
doaj   +1 more source

Distinct retroelement classes define evolutionary breakpoints demarcating sites of evolutionary novelty

BMC Genomics, 2009
Background Large-scale genome rearrangements brought about by chromosome breaks underlie numerous inherited diseases, initiate or promote many cancers and are also associated with karyotype diversification during species evolution.
Green Eric D, Carone Dawn M, Longo Mark S, O'Neill Michael J, O'Neill Rachel J   +4 more
doaj   +1 more source

Soy Isoflavone Supplementation Increases Long Interspersed Nucleotide Element-1 (LINE-1) Methylation in Head and Neck Squamous Cell Carcinoma [PDF]

Nutrition and Cancer, 2019
Soy isoflavones have been suggested as epigenetic modulating agents with effects that could be important in carcinogenesis. Hypomethylation of LINE-1 has been associated with head and neck squamous cell carcinoma (HNSCC) development from oral premalignant lesions and with poor prognosis.
Laura S. Rozek, Shama Virani, Emily L. Bellile, Jeremy M. G. Taylor, Maureen A. Sartor, Katie R. Zarins, A. Virani, C. Cote, Francis P. Worden, Mark E. Prince Mark, Scott A. McLean, Sonya A. Duffy, George H. Yoo, Nabil F. Saba, Dong M. Shin, Omer Kucuk, Gregory T. Wolf   +16 more
openaire   +2 more sources

LINE-1 Methylation Status Correlates Significantly to Post-Therapeutic Recurrence in Stage III Colon Cancer Patients Receiving FOLFOX-4 Adjuvant Chemotherapy. [PDF]

PLoS ONE, 2014
Methylation levels of long interspersed nucleotide elements (LINE-1) are representative of genome-wide methylation status and crucial in maintaining genomic stability and expression.
Yun-Ting Lou, Chao-Wen Chen, Yun-Ching Fan, Wei-Chiao Chang, Chien-Yu Lu, I-Chen Wu, Wen-Hung Hsu, Ching-Wen Huang, Jaw-Yuan Wang   +8 more
doaj   +1 more source

Induction of long interspersed nucleotide element-1 (L1) retrotransposition by 6-formylindolo[3,2- b ]carbazole (FICZ), a tryptophan photoproduct [PDF]

Proceedings of the National Academy of Sciences, 2010
Long interspersed nucleotide element-1 (L1) is a retroelement comprising about 17% of the human genome, of which 80–100 copies are competent as mobile elements (retrotransposition: L1-RTP). Although the genetic structures modified during L1-RTP have been clarified, little is known about the cellular signaling cascades involved.
Noriyuki, Okudaira, Kenta, Iijima, Takayoshi, Koyama, Yuzuru, Minemoto, Shigeyuki, Kano, Akio, Mimori, Yukihito, Ishizaka   +6 more
openaire   +2 more sources

Monitoring dynamic cytotoxic chemotherapy response in castration-resistant prostate cancer using plasma cell-free DNA (cfDNA)

BMC Research Notes, 2019
Objective Cell-free DNA (cfDNA) is an attractive cancer biomarker, as it is thought to reflect a component of the underlying genetic makeup of the tumor and is readily accessible in serial fashion.
Katherin Patsch, Naim Matasci, Anjana Soundararajan, Patricia Diaz, David B. Agus, Daniel Ruderman, Mitchell E. Gross   +6 more
doaj   +1 more source

The L1Tc, Long Interspersed Nucleotide Element from Trypanosoma cruzi, Encodes a Protein with 3′-Phosphatase and 3′-Phosphodiesterase Enzymatic Activities [PDF]

Journal of Biological Chemistry, 1999
The presence of a long interspersed nucleotide element, named L1Tc, which is actively transcribed in the parasite Trypanosoma cruzi, has been recently described. The open reading frame 1 of this element encodes the NL1Tc protein, which has apurinic/apyrimidinic endonuclease activity and is probably implicated in the first stage of the transposition of ...
M, Olivares, M C, Thomas, C, Alonso, M C, López   +3 more
openaire   +2 more sources