Results 21 to 30 of about 16,187 (162)

Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs

Mobile DNA, 2011
Long interspersed elements, type 1(LINE-1, L1) are the most abundant and only active autonomous retrotransposons in the human genome. Native L1 elements are inefficiently expressed because of a transcription elongation defect thought to be caused by high
An Wenfeng, Dai Lixin, Niewiadomska Anna, Yetil Alper, O'Donnell Kathryn A, Han Jeffrey S, Boeke Jef D   +6 more
doaj   +1 more source

MaGIC: a program to generate targeted marker sets for genome-wide association studies

BioTechniques, 2004
High-throughput genotyping technologies such as DNA pooling and DNA microarrays mean that whole-genome screens are now practical for complex disease gene discovery using association studies.
Claire L. Simpson, Valerie K. Hansen, Pak C. Sham, Andrew Collins, John F. Powell, Ammar Al-Chalabi   +5 more
doaj   +1 more source

Convergence in LINE-1 nucleotide variations can benefit redundantly forming triplexes with lncRNA in mammalian X-chromosome inactivation

Mobile DNA, 2019
Background Associations between X-inactive transcript (Xist)–long noncoding RNA (lncRNA) and chromatin are critical intermolecular interactions in the X-chromosome inactivation (XCI) process. Despite high-resolution analyses of the Xist RNA-binding sites,
Yoko Matsuno, Takefumi Yamashita, Michiru Wagatsuma, Hajime Yamakage   +3 more
doaj   +1 more source

Characterization of SR3 reveals abundance of non-LTR retrotransposons of the RTE clade in the genome of the human blood fluke, Schistosoma mansoni

BMC Genomics, 2005
Background It is becoming apparent that perhaps as much as half of the genome of the human blood fluke Schistosoma mansoni is constituted of mobile genetic element-related sequences.
Brindley Paul J, Loukas Alex, Kewgrai Nonglack, Laha Thewarach   +3 more
doaj   +1 more source

Comprehensive web-based platform for advanced PCR design, genotyping, synthetic biology, molecular diagnostics, and sequence analysis

Molecular Therapy: Nucleic Acids
We present a comprehensive web-based platform that integrates a suite of molecular biology tools tailored for PCR-based applications. Key features include custom multiplex tiling PCR panel design for amplicon sequencing, loop-mediated isothermal ...
Ruslan Kalendar
doaj   +1 more source

Mediterranean Diet and Particulate Matter Exposure Are Associated With LINE-1 Methylation: Results From a Cross-Sectional Study in Women

Frontiers in Genetics, 2018
Emerging evidence suggests that air pollution increases the risk of cardiovascular disease (CVD) and metabolic disorders, adding to the global burden of disease attributable to lifestyle and behavioral factors.
Martina Barchitta, Andrea Maugeri, Annalisa Quattrocchi, Germana Barone, Paolo Mazzoleni, Alfio Catalfo, Guido De Guidi, Guido De Guidi, Maria Giovanna Iemmolo, Nunzio Crimi, Antonella Agodi   +10 more
doaj   +1 more source

Retrotransposition of Long Interspersed Nucleotide Element-1 Is Associated with Colitis but Not Tumors in a Murine Colitic Cancer Model

PLOS ONE, 2015
Long interspersed element-1 (L1) is a transposable element that can move within the genome, potentially leading to genome diversity and modified gene function. Although L1 activity in somatic cells is normally suppressed through DNA methylation, some L1s are activated in tumors including colorectal carcinoma. However, how L1-retrotransposition (L1-RTP)
Takeshi Otsubo, Tadashi Okamura, Teruki Hagiwara, Yukihito Ishizaka, Taeko Dohi, Yuki I Kawamura   +5 more
openaire   +4 more sources

Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer.

PLoS ONE, 2014
The changes in DNA methylation status in cancer cells are characterized by hypermethylation of promoter CpG islands and diffuse genomic hypomethylation.
So Yeon Park, An Na Seo, Hae Yoen Jung, Jae Moon Gwak, Namhee Jung, Nam-Yun Cho, Gyeong Hoon Kang   +6 more
doaj   +1 more source

Comparative Genomics Provide Insights Into Karyotype Evolution in Vespertilionid Bats (Vespertilionidae, Chiroptera). [PDF]

Mol Ecol Resour
ABSTRACT Studies elucidating the molecular basis and evolutionary consequences of karyotypic changes in mammals remain scarce. Here, we investigate chromosomal evolution by focusing on two contrasting lineages within the family Vespertilionidae (Chiroptera): the karyotypically variable tribe Pipistrellini and the highly conserved genus Myotis ...
Lan L, Zhang X, Xie J, Lin X, Hong X, Nie W, Wang J, Su W, Yang F, He G, Mao X.   +10 more
europepmc   +2 more sources

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source