Results 51 to 60 of about 16,187 (162)

The 3D genome of Gigaspora margarita unveils stable chromatin and nucleolar organization and symbiont‐dependent genome dynamics

New Phytologist, EarlyView.
Summary Arbuscular mycorrhizal fungi (AMF) are widespread plant symbionts that enhance nutrient acquisition and influence ecosystem productivity. Previous chromosome‐level assemblies of the model species Rhizophagus irregularis revealed a two‐compartment genome architecture (active A and repressed B chromatin compartments), yet its conservation across ...
Ken Mugambi, Jordana Oliveira, Franco Magurno, Alessandra Salvioli di Fossalunga, Mara Novero, Luisa Lanfranco, Stefano Ghignone, Gökalp Yildirir, Yan Wang, Paola Bonfante, Nicolas Corradi   +10 more
wiley   +1 more source

Assessment of global long interspersed nucleotide element‐1 ( LINE ‐1) DNA methylation in a longitudinal cohort of type 2 diabetes mellitus (T2 DM ) individuals

International Journal of Clinical Practice, 2018
Recent studies have indicated that methylation of the LINE-1 elements is associated with an increased risk of worsening carbohydrate metabolism. It has been shown that overall DNA methylation of LINE-1 elements could be considered as a risk factor for T2DM and its complications, independent of other established risk factors.A total of 794 T2DM ...
Nagaraj Malipatil, Mark Lunt, Ram Prakash Narayanan, Kirk Siddals, Gabriela Y Cortés Moreno, Martin J. Gibson, Harvest F. Gu, Adrian H. Heald, Rachelle P. Donn   +8 more
openaire   +5 more sources

Chromosome‐Scale Haplotype Genome Assemblies for the Australian Mango ‘Kensington Pride’ and a Wild Relative, Mangifera laurina, Provide Insights Into Anthracnose‐Resistance and Volatile Compound Biosynthesis Genes

Plant Biotechnology Journal, EarlyView.
ABSTRACT Mango (Mangifera indica) is one of the most popular fruits cultivated in tropical and subtropical regions of the world. The availability of reference genomes helps to identify the genetic basis of important traits. Here, we report assembled high‐quality chromosome‐level genomes for the Australian mango cultivar ‘Kensington Pride’ and M ...
Upendra Kumari Wijesundara, Agnelo Furtado, Ardashir Kharabian Masouleh, Natalie L. Dillon, Heather E. Smyth, Robert J. Henry   +5 more
wiley   +1 more source

Involvement of retrotransposition of long interspersed nucleotide element‐1 in skin tumorigenesis induced by 7,12‐dimethylbenz[a]anthracene and 12‐O‐tetradecanoylphorbol‐13‐acetate

Cancer Science, 2011
Tumor development induced by 7,12‐dimethylbenz[a]anthracene (DMBA) plus 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) is a well‐characterized model of multistep carcinogenesis. DMBA mutates the Ha‐ras gene, whereas TPA promotes the growth of transformed cells by activating cellular signaling molecules. It remains to be clarified how repeated TPA treatment
Noriyuki, Okudaira, Motohito, Goto, Rieko, Yanobu-Takanashi, Masato, Tamura, Akihiro, An, Yukiko, Abe, Shigeyuki, Kano, Shotaro, Hagiwara, Yukihito, Ishizaka, Tadashi, Okamura   +9 more
openaire   +2 more sources

A Natural LTR Retrotransposon Insertion in the Promoter of GhNAC140‐Dt Boosts Cotton Lint Yield

Plant Biotechnology Journal, EarlyView.
ABSTRACT Transposable elements (TEs) are fundamental drivers of crop evolution and domestication. Whereas the underlying mechanisms of TE‐mediated gene activation remain poorly understood. Lint percentage is an important yield component in cotton. Here, we report a retrotransposon insertion in the promoter of GhNAC140‐Dt, a secondary wall NAC encoding ...
Yujia Yu, Xiaoguang Shang, Haitang Wang, Lijie Zhu, Xu Han, Qingfei He, Weixi Li, Yonglin Tan, Guozhong Zhu, Wangzhen Guo   +9 more
wiley   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Phylogenetic Analyses of True Ladybirds (Coleoptera: Coccinellidae: Coccinellini) Reveal Directionality in Diet Evolution and Support a Boreotropical Origin of the Tribe

Ecology and Evolution, Volume 16, Issue 4, April 2026.
A newly generated large‐scale molecular phylogeny of true ladybirds (Coccinellini) clarifies their evolutionary relationships and supports a boreotropical origin in the Paleocene, with multiple independent southward dispersals. Ancestral diet reconstructions suggest an initial specialization on aphids, followed by expansions in host range and ...
Romain Nattier, Noémie M.‐C. Hévin, Pascaline Chifflet‐Belle, Jiajia Dong, Hermes E. Escalona, Julien M. Haran, Jean‐Claude Streito, Wioletta Tomaszewska, Adam Slipiński, Andreas Zwick, Gael J. Kergoat   +10 more
wiley   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Additional file 6: Figure S3. of Prognostic and predictive significance of long interspersed nucleotide element-1 methylation in advanced-stage colorectal cancer

, 2016
Influence of clinical and histopathological parameters and of tumor LINE-1 methylation levels on the OS of patients was analyzed by Kaplan-Meier analysis. Levels of tumor LINE-1 methylation were classified as high or low based on the cutoff value (51.7%) determined by the ROC curve (Fig. 3a). (PPTX 664 kb)
Kaneko, Mami, Kotake, Masanori, Bando, Hiroyuki, Yamada, Tetsuji, Takemura, Hirofumi, Toshinari Minamoto   +5 more
openaire   +1 more source

Additional file 7: Figure S4. of Prognostic and predictive significance of long interspersed nucleotide element-1 methylation in advanced-stage colorectal cancer

, 2016
Comparison of LINE-1 scores determined by FAIRE in LINE-1-expressing (SW480, Caco2) and non-expressing (HCT116, RKO) colon cancer cells that were treated with or without 2 ÎźM oxaliplatin for 2 hrs. The primer set (2) (Additional file 1: Table S1) was used for FAIRE analysis. (PPTX 38 kb)
Kaneko, Mami, Kotake, Masanori, Bando, Hiroyuki, Yamada, Tetsuji, Takemura, Hirofumi, Toshinari Minamoto   +5 more
openaire   +1 more source