Results 11 to 20 of about 605,748 (301)
Long non-coding RNA-polycomb intimate rendezvous [PDF]
Open Biology, 2020 The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate.
Andrea Cerase, Gian Gaetano Tartaglia
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Long Non-Coding RNA Epigenetics [PDF]
International Journal of Molecular Sciences, 2021 Long noncoding RNAs exceeding a length of 200 nucleotides play an important role in ensuring cell functions and proper organism development by interacting with cellular compounds such as miRNA, mRNA, DNA and proteins. However, there is an additional level of lncRNA regulation, called lncRNA epigenetics, in gene expression control.
Marek Kazimierczyk, Jan Wrzesinski
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Long Non-Coding RNAs in Insects [PDF]
Animals, 2021 Only a small subset of all the transcribed RNAs are used as a template for protein translation, whereas RNA molecules that are not translated play a very important role as regulatory non-coding RNAs (ncRNAs). Besides traditionally known RNAs (ribosomal and transfer RNAs), ncRNAs also include small non-coding RNAs (sncRNAs) and long non-coding RNAs ...
Chhavi Choudhary +9 more
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Long non‐coding RNA modifies chromatin [PDF]
BioEssays, 2011 AbstractCommon themes are emerging in the molecular mechanisms of long non‐coding RNA‐mediated gene repression. Long non‐coding RNAs (lncRNAs) participate in targeted gene silencing through chromatin remodelling, nuclear reorganisation, formation of a silencing domain and precise control over the entry of genes into silent compartments.
Alka Saxena, Piero Carninci??
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Long Non-Coding RNA in Cancer [PDF]
International Journal of Molecular Sciences, 2013 Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are emerging as new players in tumorigenesis due to their various functions in transcriptional, posttranscriptional and epigenetic mechanisms of gene regulation. LncRNAs are deregulated in a number of cancers, demonstrating both oncogenic and tumor suppressive roles, thus ...
Nina Hauptman, Damjan Glavač
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Long non-coding RNAs in oncourology
Non-coding RNA Research, 2021 For several decades, research in tumor biology has focused on the involvement of genes encoding a protein. Only recently has it been discovered that a whole class of molecules called non-coding RNAs (ncRNAs) play a key regulatory role in health and disease. Long noncoding RNAs (lncRNAs) are a group of noncoding RNAs longer than 200 nucleotides.
Ilgiz Gareev +10 more
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Long non-coding RNAs in cancer [PDF]
Science China Life Sciences, 2012 Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, the Third Xiangya Hospital, Central South University, Changsha 410013, China; Key Laboratory of Carcinogenesis of Ministry of Health, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South ...
Gong, ZhaoJian +15 more
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The Role of Non-Coding RNAs in Glioma
Biomedicines, 2022 For decades, research in cancer biology has been focused on the protein-coding fraction of the human genome. However, with the discovery of non-coding RNAs (ncRNAs), it has become known that these entities not only function in numerous fundamental life ...
Anshika Goenka +6 more
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Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. [PDF]
, 2019 Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under investigation for multiple nervous system disorders, including Alzheimer's disease (AD).
Balaraman, Yokesh +7 more
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Long non-coding RNAs and enhancers [PDF]
Current Opinion in Genetics & Development, 2011 Long non-coding RNAs (ncRNAs) are emerging as important regulatory factors in mammalian genomics. A number of reports within the last 2 years have identified thousands of actively expressed long ncRNA transcripts with distinct properties. The long ncRNAs show differential expression patterns and regulation in a wide variety of cells and tissues, adding
Ulf Andersson, Ørom, Ramin, Shiekhattar
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