Results 21 to 30 of about 614,602 (305)
Long non-coding RNA-polycomb intimate rendezvous [PDF]
Open Biology, 2020 The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate.
Andrea Cerase, Gian Gaetano Tartaglia
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Long Non-Coding RNAs in Endometrial Carcinoma [PDF]
International Journal of Molecular Sciences, 2015 Endometrial carcinoma (EC), the second most common form of gynaecological malignancy, can be divided into two distinct sub-types: Type I tumours arise from hyperplastic endometrium and typically effect women around the time of menopause, whereas type II tumours arise in postmenopausal women from atrophic endometrium.
Maria Smolle +4 more
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The Role of Long Non-Coding RNAs in Endometriosis [PDF]
International Journal of Molecular Sciences, 2021 Endometriosis is a chronic gynecological disorder affecting the quality of life and fertility of many women around the world. Heterogeneous and non-specific symptoms may lead to a delay in diagnosis, with treatment options limited to surgery and hormonal therapy.
Quanah J. Hudson +6 more
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Long non-coding RNAs in cancer progression [PDF]
Frontiers in Genetics, 2012 Recent large-scale transcriptome analyses have revealed that transcription is spread throughout the mammalian genomes, yielding large numbers of transcripts, including long non-coding RNAs (lncRNAs) with little or no protein-coding capacity. Dozens of lncRNAs have been identified as biologically significant.
Tano, Keiko, Akimitsu, Nobuyoshi
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Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling
EMBO Molecular Medicine, 2016 The nervous and vascular systems, although functionally different, share many common regulators of function maintenance. Long non‐coding RNAs (lncRNAs) are important players in many biological processes and human disorders.
Jin Yao +15 more
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Long non-coding RNA and diseases [PDF]
Jichu yixue yu linchuangLong non-coding RNA (lncRNA) is a class of endogenous non-coding RNA with a length of more than 200 nt. Due to lack of open reading frame (ORF), they lack the ability to directly encode proteins, but they play a crucial role in gene regulation.
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Long non-coding RNAs in osteosarcoma
Oncotarget, 2017 Long non-coding RNAs (lncRNAs) with more than 200 nuleotides, have been explored to participate in various cancer types including osteosarcoma (OS), which is the most common kind of primary bone tumors with high morbidity in infants and adolescents.
Chen, Ruiling +4 more
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An autophagy‐related long non‐coding RNA signature for glioma
FEBS Open Bio, 2019 Glioma is one of the most common types of malignant primary central nervous system tumor, and prognosis for this disease is poor. As autophagic drugs have been reported to induce glioma cell death, we investigated the potential prognostic role of ...
Fangkun Luan +7 more
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Human cancer long non-coding RNA transcriptomes. [PDF]
PLoS ONE, 2011 Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome.
Ewan A Gibb +10 more
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Role of Non-Coding RNAs in Colorectal Cancer: Focus on Long Non-Coding RNAs
International Journal of Molecular Sciences, 2022 Colorectal cancer is one of the most common causes of cancer-related deaths worldwide. Despite the advances in the knowledge of pathogenetic molecular mechanisms and the implementation of more effective drug treatments in recent years, the overall survival rate of patients remains unsatisfactory.
Lulli, Matteo +4 more
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