Results 41 to 50 of about 605,748 (301)

Non-coding RNAs and glioblastoma: Insight into their roles in metastasis

Molecular Therapy: Oncolytics, 2022
Glioma, also known as glioblastoma multiforme (GBM), is the most prevalent and most lethal primary brain tumor in adults. Gliomas are highly invasive tumors with the highest death rate among all primary brain malignancies.
Seyed Mojtaba Mousavi, Maryam Derakhshan, Fatereh Baharloii, Fatemeh Dashti, Seyed Mohammad Ali Mirazimi, Maryam Mahjoubin-Tehran, Saereh Hosseindoost, Pouya Goleij, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei   +10 more
doaj   +1 more source

Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome [PDF]

, 2012
Brain aging frequently underlies cognitive decline and is a major risk factor for neurodegenerative conditions. The exact molecular mechanisms underlying brain aging, however, remain unknown. Whole transcriptome sequencing provides unparalleled depth and
Brian Merry, João Pedro de Magalhães, Shona H. Wood, Thomas Craig, Yang Li   +4 more
core   +1 more source

Long non‐coding small nucleolar RNA host genes in digestive cancers

Cancer Medicine, 2019
Although long noncoding RNAs (lncRNAs) do not have protein coding capacities, they are involved in the pathogenesis of many types of cancers, including hepatocellular carcinoma, cervical cancer, and gastric cancer. Notably, the roles of lncRNAs are vital
Huan Yang, Zheng Jiang, Shuang Wang, Yongbing Zhao, Xiaomei Song, Yufeng Xiao, Shiming Yang   +6 more
doaj   +1 more source

Review: Long non-coding RNA in livestock

Animal, 2020
Less than 2% of mammalian genomes code for proteins, but ‘the majority of its bases can be found in primary transcripts’ – a phenomenon termed the pervasive transcription, which was first reported in 2007.
B. Kosinska-Selbi, M. Mielczarek, J. Szyda   +2 more
doaj   +1 more source

Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers [PDF]

, 2012
Background: Molecular characterization of tumors has been critical for identifying important genes in cancer biology and for improving tumor classification and diagnosis.
Beck, Andrew H, Brunner, Alayne L, Chang, Howard Y, Edris, Badreddin, Flynn, Ryan A, Foley, Joseph W, Giacomini, Craig P, Gilks, Thea, Guo, Xiangqian, Li, Rui, Montgomery, Kelli, Pollack, Jonathan R, Sweeney, Robert T, Tibshirani, Robert, van de Rijn, Matt, Varma, Sushama, West, Robert B, Witten, Daniela M, Zhu, Shirley X   +18 more
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Construction of asthma related competing endogenous RNA network revealed novel long non-coding RNAs and potential new drugs

Respiratory Research, 2020
Background Asthma is a heterogeneous disease characterized by chronic airway inflammation. Long non-coding RNA can act as competing endogenous RNA to mRNA, and play significant role in many diseases.
Yifang Liao, Ping Li, Yanxia Wang, Hong Chen, Shangwei Ning, Dongju Su   +5 more
doaj   +1 more source

Complete genome sequence of Spirosoma linguale type strain (1). [PDF]

, 2010
Spirosoma linguale Migula 1894 is the type species of the genus. S. linguale is a free-living and non-pathogenic organism, known for its peculiar ringlike and horseshoe-shaped cell morphology. Here we describe the features of this organism, together with
Brettin, Thomas, Bristow, Jim, Bruce, David, Chain, Patrick, Chang, Yun-Juan, Chen, Amy, Chen, Feng, Cheng, Jan-Fang, Copeland, Alex, Detter, John C, Eisen, Jonathan A, Glavina Del Rio, Tijana, Goodwin, Lynne, Göker, Markus, Hauser, Loren, Hugenholtz, Philip, Ivanova, Natalia, Jeffries, Cynthia D, Klenk, Hans-Peter, Kyrpides, Nikos C, Lail, Kathleen, Land, Miriam, Lapidus, Alla, Lucas, Susan, Markowitz, Victor, Mavromatis, Konstantinos, Nolan, Matt, Ovchinnikova, Galina, Palaniappan, Krishna, Pati, Amrita, Pitluck, Sam, Rohde, Manfred, Saunders, Elizabeth, Schütze, Andrea, Sikorski, Johannes, Tice, Hope, Tindall, Brian J   +36 more
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The lncRNA PARylator promotes PARP1 activation and resistance to DNA‑damaging therapy in esophageal squamous cell carcinoma

Experimental Hematology & Oncology
Background Outcomes for patients with esophageal squamous cell carcinoma (ESCC) remain poor, partly due to treatment resistance, particularly to DNA-damaging therapies.
Teng Fei Qi, Yadong Liu, Jinkun Yang, Yi Meng Yue, Man Man Han, Hongtao Liu, Jing Li, Min Liu, Yuwei Zhang, Jia Hui Kou, Wen Jin Li, Xiaoying Liu, Ting La, Tao Liu, Song Chen, Xu Dong Zhang, Shundong Cang, Liu Teng, Tianli Fan   +18 more
doaj   +1 more source

Pathophysiology and Clinical Utility of Non-coding RNAs in Epilepsy

Frontiers in Molecular Neuroscience, 2017
Epilepsy is a common neurologic disorder. The underlying pathological processes include synaptic strength, inflammation, ion channels, and apoptosis. Acting as epigenetic factors, non-coding RNAs (ncRNAs) participate in the regulation of pathophysiologic
Yiye Shao, Yiye Shao, Yinghui Chen, Yinghui Chen   +3 more
doaj   +1 more source

CAHM, a long non-coding RNA gene hypermethylated in colorectal neoplasia [PDF]

, 2014
Copyright © 2014 Landes Bioscience This is an open-access article licensed under a Creative Commons Attribution 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is
Baker, Rohan T, Graham, Lloyd D, Ho, Thu, LaPointe, Lawrence C, McEvoy, Aidan, Mitchell, Susan M, Molloy, Peter L, Pedersen, Susanne K, Ross, Jason P, Thomas, Melissa, Xu, Zheng-Zhou, Young, Graeme Paul   +11 more
core   +1 more source