Results 41 to 50 of about 718,965 (394)

Long non-coding RNAs in cancer progression [PDF]

Frontiers in Genetics, 2012
Recent large-scale transcriptome analyses have revealed that transcription is spread throughout the mammalian genomes, yielding large numbers of transcripts, including long non-coding RNAs (lncRNAs) with little or no protein-coding capacity. Dozens of lncRNAs have been identified as biologically significant.
Nobuyoshi Akimitsu, Keiko Tano
openaire   +4 more sources

Exosomal transfer of long non-coding RNA SBF2-AS1 enhances chemoresistance to temozolomide in glioblastoma

Journal of experimental & clinical cancer research : CR, 2019
Acquired drug resistance is a constraining factor in clinical treatment of glioblastoma (GBM). However, the mechanisms of chemoresponsive tumors acquire therapeutic resistance remain poorly understood.
Zhuoran Zhang, Jianxin Yin, Chenfei Lu, Yutian Wei, Ailiang Zeng, Y. You   +5 more
semanticscholar   +1 more source

Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma. [PDF]

, 2017
Long non-coding RNAs (lncRNAs) have a critical role in cancer initiation and progression, and thus may mediate oncogenic or tumor suppressing effects, as well as be a new class of cancer therapeutic targets. We performed high-throughput sequencing of RNA
Ai, B, Bai, X-F, Cao, H-H, Feng, C-C, He, J-Z, Huang, G-W, Koeffler, HP, Lei, F, Li, C-Q, Li, E-M, Li, M, Li, S, Li, X, Li, X-C, Liao, L-D, Lin, D-C, Liu, Y-J, Shen, J-H, Tang, Z-D, Wang, L-D, Wang, M-R, Wang, Q-Y, Wang, S-H, Wu, B-L, Wu, J-Y, Wu, Z-Y, Xu, L-Y, Xu, Y-J, Xue, Y-J, Zhang, J, Zhao, J-M, Zheng, C-P, Zhu, Y   +32 more
core   +1 more source

Human cancer long non-coding RNA transcriptomes. [PDF]

PLoS ONE, 2011
Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome.
Ewan A Gibb, Emily A Vucic, Katey S S Enfield, Greg L Stewart, Kim M Lonergan, Jennifer Y Kennett, Daiana D Becker-Santos, Calum E MacAulay, Stephen Lam, Carolyn J Brown, Wan L Lam   +10 more
doaj   +1 more source

Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine

Molecular Cancer, 2020
Background N6-methyladenosine (m6A) is the most prevalent messenger RNA modification in mammalian cells. However, the disease relevant function of m6A on specific oncogenic long non-coding RNAs (ncRNAs) is not well understood. Methods We analyzed the m6A
Simeng Wen, Yulei Wei, Chong Zen, W. Xiong, Y. Niu, Yu Zhao   +5 more
semanticscholar   +1 more source

A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression [PDF]

, 2015
Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are ...
AC Thénié, B Holmqvist, B Kuzin, B Moreno-Lopez, BL Sopher, C-H Cheng, D Dahary, DS Bredt, E Ciani, E Pavesi, GB Robb, J Chen, J Garthwaite, J-T Li, JB Kelley, JE Fish, JH Brann, K Matsui, KY Kwan, L Zhou, MA Faghihi, MA Packer, ME Evangelopoulos, ME Evangelopoulos, MHT Ling, N Peunova, P Ogilvie, RG Tremblay, S Hindley, S Korneev, SA Korneev, SA Korneev, SA Korneev, SA Korneev, SM Gibbs, SR Vincent, U Forstermann, V Calabrese, Y Zhang   +38 more
core   +1 more source

Regulation of metabolism by long, non-coding RNAs [PDF]

Frontiers in Genetics, 2014
Our understanding of genomic regulation was revolutionized by the discovery that the genome is pervasively transcribed, giving rise to thousands of mostly uncharacterized non-coding ribonucleic acids (ncRNAs). Long, ncRNAs (lncRNAs) have thus emerged as a novel class of functional RNAs that impinge on gene regulation by a broad spectrum of mechanisms ...
Jens C. Brüning, Jan-Wilhelm Kornfeld
openaire   +4 more sources

Long non-coding RNA and diseases [PDF]

Jichu yixue yu linchuang
Long non-coding RNA (lncRNA) is a class of endogenous non-coding RNA with a length of more than 200 nt. Due to lack of open reading frame (ORF), they lack the ability to directly encode proteins, but they play a crucial role in gene regulation.

doaj   +1 more source

LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases

Nucleic Acids Res., 2018
Mounting evidence suggested that dysfunction of long non-coding RNAs (lncRNAs) is involved in a wide variety of diseases. A knowledgebase with systematic collection and curation of lncRNA-disease associations is critically important for further examining
Zhenyu Bao, Zhen Yang, Zhou Huang, Yiran Zhou, Qinghua Cui, Dong Dong   +5 more
semanticscholar   +1 more source

Long non-coding RNAs in osteosarcoma

Oncotarget, 2017
Long non-coding RNAs (lncRNAs) with more than 200 nuleotides, have been explored to participate in various cancer types including osteosarcoma (OS), which is the most common kind of primary bone tumors with high morbidity in infants and adolescents.
Yingqi Hua, Zhengdong Cai, Gangyang Wang, Ying Zheng, Ruiling Chen   +4 more
openaire   +3 more sources