Results 41 to 50 of about 739,569 (400)
Long non-coding RNA and diseases [PDF]
Jichu yixue yu linchuangLong non-coding RNA (lncRNA) is a class of endogenous non-coding RNA with a length of more than 200 nt. Due to lack of open reading frame (ORF), they lack the ability to directly encode proteins, but they play a crucial role in gene regulation.
doaj +1 more source
Human cancer long non-coding RNA transcriptomes. [PDF]
PLoS ONE, 2011 Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome.
Ewan A Gibb +10 more
doaj +1 more source
Regulation of Peripheral Myelination through Transcriptional Buffering of Egr2 by an Antisense Long Non-coding RNA [PDF]
, 2017 Precise regulation of Egr2 transcription is fundamentally important to the control of peripheral myelination. Here, we describe a long non-coding RNA antisense to the promoter of Egr2 (Egr2-AS-RNA).
Langer, Robert S +6 more
core +2 more sources
Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine
Molecular Cancer, 2020 Background N6-methyladenosine (m6A) is the most prevalent messenger RNA modification in mammalian cells. However, the disease relevant function of m6A on specific oncogenic long non-coding RNAs (ncRNAs) is not well understood. Methods We analyzed the m6A
Simeng Wen +5 more
semanticscholar +1 more source
Long non-coding RNAs in cancer progression [PDF]
Frontiers in Genetics, 2012 Recent large-scale transcriptome analyses have revealed that transcription is spread throughout the mammalian genomes, yielding large numbers of transcripts, including long non-coding RNAs (lncRNAs) with little or no protein-coding capacity. Dozens of lncRNAs have been identified as biologically significant.
Tano, Keiko, Akimitsu, Nobuyoshi
openaire +3 more sources
Long Non-Coding RNAs in Cardiac Hypertrophy [PDF]
Frontiers in Molecular Medicine, 2022 Heart disease represents one of the main challenges in modern medicine with insufficient treatment options. Whole genome sequencing allowed for the discovery of several classes of non-coding RNA (ncRNA) and widened our understanding of disease regulatory circuits.
Mangraviti, Nicolò, De Windt, Leon J
openaire +2 more sources
A long non-coding RNA protects the heart from pathological hypertrophy [PDF]
, 2014 The role of long noncoding RNA (lncRNA) in adult hearts is unknownalso unclear is how lncRNA modulates nucleosome remodeling. An estimated 70% of mouse genes undergo antisense transcription, including myosin heavy chain 7 (Myh7) that encodes molecular ...
Ashley, Euan +18 more
core +5 more sources
An autophagy‐related long non‐coding RNA signature for glioma
FEBS Open Bio, 2019 Glioma is one of the most common types of malignant primary central nervous system tumor, and prognosis for this disease is poor. As autophagic drugs have been reported to induce glioma cell death, we investigated the potential prognostic role of ...
Fangkun Luan +7 more
doaj +1 more source
Identification and function of long non-coding RNA [PDF]
, 2013 Long non-coding (lnc) RNAs are defined as non-protein coding RNAs distinct from housekeeping RNAs such as tRNAs, rRNAs, and snRNAs, and independent from small RNAs with specific molecular processing machinery such as micro- or piwi-RNAs.
Ernst, Carl, Morton, Cynthia C.
core +2 more sources
Molecular Cancer, 2019 The long non-coding RNA PVT1 (lncRNA PVT1) has been reported to act as an oncogenic regulator of several cancers. However, its expression and function in gallbladder cancer (GBC) remain largely unknown.
Jianan Chen +13 more
semanticscholar +1 more source