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Regulation of Peripheral Myelination through Transcriptional Buffering of Egr2 by an Antisense Long Non-coding RNA [PDF]
, 2017 Precise regulation of Egr2 transcription is fundamentally important to the control of peripheral myelination. Here, we describe a long non-coding RNA antisense to the promoter of Egr2 (Egr2-AS-RNA).
Langer, Robert S +6 more
core +2 more sources
Long Non-Coding RNAs in Haematological Malignancies [PDF]
International Journal of Molecular Sciences, 2013 Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides in length. LncRNAs are as diverse as mRNAs and they normally share the same biosynthetic machinery based on RNA polymerase II, splicing and polyadenylation. However, lncRNAs have low coding potential.
Andoni Garitano-Trojaola +3 more
openalex +5 more sources
Long Non-Coding RNAs in Neuronal Aging [PDF]
Non-Coding RNA, 2018 The expansion of long non-coding RNAs (lncRNAs) in organismal genomes has been associated with the emergence of sophisticated regulatory networks that may have contributed to more complex neuronal processes, such as higher-order cognition. In line with the important roles of lncRNAs in the normal functioning of the human brain, dysregulation of lncRNA ...
Pereira Fernandes, D. +3 more
openaire +5 more sources
An autophagy‐related long non‐coding RNA signature for glioma
FEBS Open Bio, 2019 Glioma is one of the most common types of malignant primary central nervous system tumor, and prognosis for this disease is poor. As autophagic drugs have been reported to induce glioma cell death, we investigated the potential prognostic role of ...
Fangkun Luan +7 more
doaj +1 more source
Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/$\beta$-catenin signaling pathway [PDF]
Journal of Integrative Neuroscience, 2018 Chronic stress is one of the major causes that lead to major depressive disorder, which is a prevalent mood disorder worldwide. Many patients with major depressive disorder do not benefit from available medication due to the complex etiology of the ...
Xinqiang Ni, Yingzhao Liao, Limin Li, Xiaoli Zhang, Zhengzhi Wu
doaj +1 more source
Molecular Cancer, 2019 The long non-coding RNA PVT1 (lncRNA PVT1) has been reported to act as an oncogenic regulator of several cancers. However, its expression and function in gallbladder cancer (GBC) remain largely unknown.
Jianan Chen +13 more
semanticscholar +1 more source
The Role of Long Non-Coding RNAs in Hepatocarcinogenesis [PDF]
International Journal of Molecular Sciences, 2018 Whole-transcriptome analyses have revealed that a large proportion of the human genome is transcribed in non-protein-coding transcripts, designated as long non-coding RNAs (lncRNAs). Rather than being “transcriptional noise”, increasing evidence indicates that lncRNAs are key players in the regulation of many biological processes, including ...
Luigi Terracciano +5 more
openaire +5 more sources
A long non-coding RNA protects the heart from pathological hypertrophy [PDF]
, 2014 The role of long noncoding RNA (lncRNA) in adult hearts is unknownalso unclear is how lncRNA modulates nucleosome remodeling. An estimated 70% of mouse genes undergo antisense transcription, including myosin heavy chain 7 (Myh7) that encodes molecular ...
Ashley, Euan +18 more
core +5 more sources
Non-coding RNAs and glioblastoma: Insight into their roles in metastasis
Molecular Therapy: Oncolytics, 2022 Glioma, also known as glioblastoma multiforme (GBM), is the most prevalent and most lethal primary brain tumor in adults. Gliomas are highly invasive tumors with the highest death rate among all primary brain malignancies.
Seyed Mojtaba Mousavi +10 more
doaj +1 more source
Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome [PDF]
, 2012 Brain aging frequently underlies cognitive decline and is a major risk factor for neurodegenerative conditions. The exact molecular mechanisms underlying brain aging, however, remain unknown. Whole transcriptome sequencing provides unparalleled depth and
Brian Merry +4 more
core +1 more source