Results 51 to 60 of about 728,039 (351)
Long non‐coding small nucleolar RNA host genes in digestive cancers
Cancer Medicine, 2019 Although long noncoding RNAs (lncRNAs) do not have protein coding capacities, they are involved in the pathogenesis of many types of cancers, including hepatocellular carcinoma, cervical cancer, and gastric cancer. Notably, the roles of lncRNAs are vital
Huan Yang +6 more
doaj +1 more source
EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks [PDF]
, 2019 The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is an essential step in homologous ...
Bonath, Franziska +7 more
core +2 more sources
Pathophysiology and Clinical Utility of Non-coding RNAs in Epilepsy
Frontiers in Molecular Neuroscience, 2017 Epilepsy is a common neurologic disorder. The underlying pathological processes include synaptic strength, inflammation, ion channels, and apoptosis. Acting as epigenetic factors, non-coding RNAs (ncRNAs) participate in the regulation of pathophysiologic
Yiye Shao +3 more
doaj +1 more source
Long intergenic non-coding RNA expression signature in human breast cancer [PDF]
, 2016 Breast cancer is a complex disease, characterized by gene deregulation. There is less systematic investigation of the capacity of long intergenic non-coding RNAs (lincRNAs) as biomarkers associated with breast cancer pathogenesis or several ...
Cai, Qiuyin +7 more
core +1 more source
Molecular Cancer, 2019 Gallbladder cancer is the most common biliary tract malignancy and not sensitive to chemotherapy. Autophagy is an important factor prolonging the survival of cancer cells under chemotherapeutic stress.
Qiang Cai +7 more
semanticscholar +1 more source
Long Non-coding RNA in Plants in the Era of Reference Sequences
Frontiers in Plant Science, 2020 The discovery of non-coding RNAs (ncRNAs), and the subsequent elucidation of their functional roles, was largely delayed due to the misidentification of non-protein-coding parts of DNA as “junk DNA,” which forced ncRNAs into the shadows of their protein ...
H. Budak, Sezgi Kaya, H. B. Cagirici
semanticscholar +1 more source
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
Role of MicroRNAs and Long Non-Coding RNAs in Sarcopenia
Cells, 2022 Sarcopenia is an age-related pathological process characterized by loss of muscle mass and function, which consequently affects the quality of life of the elderly.
Jihui Lee, Hara Kang
doaj +1 more source
Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages. [PDF]
, 2015 To elucidate the transcriptional 'landscape' that regulates human lymphoid commitment during postnatal life, we used RNA sequencing to assemble the long non-coding transcriptome across human bone marrow and thymic progenitor cells spanning the earliest ...
Casero, David +8 more
core
CAHM, a long non-coding RNA gene hypermethylated in colorectal neoplasia [PDF]
, 2014 Copyright © 2014 Landes Bioscience This is an open-access article licensed under a Creative Commons Attribution 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is
Baker, Rohan T +11 more
core +1 more source