Results 61 to 70 of about 605,748 (301)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Long non coding RNA H19: An emerging therapeutic target in fibrosing diseases

Autoimmunity, 2020
Fibrosis is characterised by excessive deposition of the extracellular matrix (ECM) and develops because of fibroblast differentiation during the process of inflammation. There are few effective treatment options for this diseases due to the aetiology of
Juan Li, Long-Ting Cao, Hong-Hui Liu, Xiao-Dong Yin, Jing Wang   +4 more
doaj   +1 more source

Long intergenic non-coding RNA expression signature in human breast cancer [PDF]

, 2016
Breast cancer is a complex disease, characterized by gene deregulation. There is less systematic investigation of the capacity of long intergenic non-coding RNAs (lincRNAs) as biomarkers associated with breast cancer pathogenesis or several ...
Cai, Qiuyin, Guo, Xingyi, He, Chunyan, Long, Jirong, May, Isaac, Wagner, Erin K., Zhang, Yanfeng, Zheng, Wei   +7 more
core   +1 more source

Uncovering RNA Editing Sites in Long Non-Coding RNAs [PDF]

Frontiers in Bioengineering and Biotechnology, 2014
RNA editing is an important co/post-transcriptional molecular process able to modify RNAs by nucleotide insertions/deletions or substitutions. In human, the most common RNA editing event involves the deamination of adenosine (A) into inosine (I) through the adenosine deaminase acting on RNA proteins. Although A-to-I editing can occur in both coding and
Ernesto ePicardi, Ernesto ePicardi, Anna Maria D'Erchia, Anna Maria D'Erchia, Angela eGallo, Antonio eMontalvo, Antonio eMontalvo, Graziano ePesole, Graziano ePesole   +8 more
openaire   +5 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Probing Long Non-coding RNA-Protein Interactions

Frontiers in Molecular Biosciences, 2017
Non-coding RNA sequences outnumber the protein-coding genes in the human genome, however our knowledge of their functions is still limited. RNA-binding proteins follow the transcripts, including non-coding RNAs, throughout their life, regulating not only
Jasmine Barra, Jasmine Barra, Eleonora Leucci   +2 more
doaj   +1 more source

Identification of long non-protein coding RNAs in chicken skeletal muscle using next generation sequencing [PDF]

Vertebrate genomes encode thousands of non-coding RNAs including short non-coding RNAs (such as microRNAs) and long non-coding RNAs (lncRNAs). Chicken (Gallus gallus) is an important model organism for developmental biology, and the recently assembled ...
Li, Tingting, Wang, Suya, Wu, Rimao, Zhou, Xueya, Zhu, Dahai, Zhang, Yong   +5 more
core   +1 more source

Into the Wild: GWAS Exploration of Non-coding RNAs [PDF]

, 2018
Genome-wide association studies (GWAS) have proven a fundamental tool to identify common variants associated to complex traits, thus contributing to unveil the genetic components of human disease.
Giral, Hector, Kratzer, Adelheid, Landmesser, Ulf   +2 more
core   +1 more source

Long Non-Coding RNAs in Haematological Malignancies [PDF]

International Journal of Molecular Sciences, 2013
Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides in length. LncRNAs are as diverse as mRNAs and they normally share the same biosynthetic machinery based on RNA polymerase II, splicing and polyadenylation. However, lncRNAs have low coding potential.
Andoni Garitano-Trojaola, Xabier Agirre, Felipe Prósper, Puri Fortes   +3 more
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source