Results 61 to 70 of about 588,548 (249)

Long Non-coding RNAs in Myeloid Malignancies [PDF]

Frontiers in Oncology, 2019
Acute myeloid leukemia (AML) represents 80% of adult leukemias and 15-20% of childhood leukemias. AML are characterized by the presence of 20% blasts or more in the bone marrow, or defining cytogenetic abnormalities. Laboratory diagnoses of myelodysplastic syndromes (MDS) depend on morphological changes based on dysplasia in peripheral blood and bone ...
Alina-Andreea Zimta, Ciprian Tomuleasa, Ciprian Tomuleasa, Iman Sahnoune, George A. Calin, George A. Calin, Ioana Berindan-Neagoe, Ioana Berindan-Neagoe   +7 more
openaire   +4 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The complex transcriptional landscape of the anucleate human platelet. [PDF]

, 2013
BACKGROUND: Human blood platelets are essential to maintaining normal hemostasis, and platelet dysfunction often causes bleeding or thrombosis. Estimates of genome-wide platelet RNA expression using microarrays have provided insights to the platelet ...
Bray, Paul F, Chen, Huang-Wen, Delgrosso, Kathleen, Edelstein, Leonard, Ertel, Adam, Fortina, Paolo, Jing, Yi, Kupper, Joan, Loher, Phillipe, Londin, Eric R, McKenzie, Steven E, Nagalla, Srikanth, Rigoutsos, Isidore   +12 more
core   +1 more source

Long Non-coding RNAs in Endothelial Biology [PDF]

Frontiers in Physiology, 2018
In recent years, the role of RNA has expanded to the extent that protein-coding RNAs are now the minority with a variety of non-coding RNAs (ncRNAs) now comprising the majority of RNAs in higher organisms. A major contributor to this shift in understanding is RNA sequencing (RNA-seq), which allows a largely unconstrained method for monitoring the ...
Giuseppe Militello, Tyler Weirick, Shizuka Uchida   +2 more
openaire   +4 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Long non coding RNA H19: An emerging therapeutic target in fibrosing diseases

Autoimmunity, 2020
Fibrosis is characterised by excessive deposition of the extracellular matrix (ECM) and develops because of fibroblast differentiation during the process of inflammation. There are few effective treatment options for this diseases due to the aetiology of
Juan Li, Long-Ting Cao, Hong-Hui Liu, Xiao-Dong Yin, Jing Wang   +4 more
doaj   +1 more source

Non-coding RNA as lung disease biomarkers. [PDF]

, 2015
Biomarkers are quantifiable indicators of disease. These surrogates should be specific, sensitive, predictive, robust and easily accessible. A major class of RNA described as non-coding RNA fulfils many of these criteria, and recent studies have ...
Greene, Catherine M, McKiernan, Paul J, Vencken, Sebastian F   +2 more
core   +1 more source

Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome [PDF]

, 2012
Brain aging frequently underlies cognitive decline and is a major risk factor for neurodegenerative conditions. The exact molecular mechanisms underlying brain aging, however, remain unknown. Whole transcriptome sequencing provides unparalleled depth and
Brian Merry, João Pedro de Magalhães, Shona H. Wood, Thomas Craig, Yang Li   +4 more
core   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source