Results 211 to 220 of about 6,663,585 (252)

Intronic polyadenylation-derived long noncoding RNA modulates nucleolar integrity and function. [PDF]

Proc Natl Acad Sci U S A
Mallick S, Borkar P, Thind J, Chung D, Hubbs T, Singh I.   +5 more
europepmc   +1 more source

Breaking the ice: multiple origins of ice‐binding/antifreeze proteins

The FEBS Journal, EarlyView.
Ice‐binding proteins (IBPs) evolved independently in many organisms during Cenozoic cooling and glaciation. In flounders, α‐helical IBPs evolved from an antiviral protein, while similar IBPs arose independently from different progenitors in three other fish lineages.
Laurie A. Graham, Peter L. Davies
wiley   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi-Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin. [PDF]

Adv Sci (Weinh)
Yao Y, Jiang P, Zhou X, Yin M, Luo Q, Wang H.   +5 more
europepmc   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

A long noncoding RNA modulates anthocyanin biosynthesis in Camellia sinensis. [PDF]

Commun Biol
Xiong B, Zhang L, Li Q, Yang Y, Wang B, Song Q, Cronk Q, Niu S.   +7 more
europepmc   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Retraction: Long Noncoding RNA MEG3 Suppresses Glioma Cell Proliferation, Migration, and Invasion by Acting as a Competing Endogenous RNA of miR-19a. [PDF]

Oncol Res
Oncology Research Editorial Office.
europepmc   +1 more source

Unmasking the Influence of Viral Micro‐RNAs on Host Immunity

Immunology &Cell Biology, EarlyView.
Viral micro‐RNAs are increasingly recognized as key modulators of host–virus interactions. They influence multiple immune functions, including antigen presentation, T‐cell activation, and cytokine signaling, while also tuning viral gene expression to promote persistence.
Riley J. K. Easton, Bernadette M. Saunders   +1 more
wiley   +1 more source

A B1 SINE element within the mouse <i>Malat1</i> long noncoding RNA acts as an internal ribosome entry site mediating micropeptide translation. [PDF]

Sci Adv
Xiao W, Hann T, Perry Z, Pandey V, Cheng J, Wohlschlegel J, Pyle AM, Black DL.   +7 more
europepmc   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source