Results 51 to 60 of about 436,258 (285)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Multicellular String-Like Structure Formation by Salmonella Typhimurium Depends on Cellulose Production: Roles of Diguanylate Cyclases, YedQ and YfiN

open access: yesFrontiers in Microbiology, 2020
Bacteria face diverse stresses in the environment and, sometimes, respond by forming multi-cellular structures, e.g., biofilms. Here, we report a novel macroscopic and multi-cellular structure formed by Salmonella Typhimurium, which resembles small ...
Alan Varghese   +3 more
doaj   +1 more source

Gravitating spinning strings in AdS3

open access: yesJournal of High Energy Physics, 2022
In the AdS/CFT correspondence, single trace operators of large-N gauge theories at large spin J can be described by classical spinning strings, giving a geometric and classical description of their spectrum at strong coupling.
Henry Maxfield, Zhencheng Wang
doaj   +1 more source

Extrusion deformation estimation method of oil and gas string basedon AIC-RBF

open access: yesYou-qi chuyun, 2021
It is difficult to measure the deformation of oil and gas strings affected by the ground movement for a long time. In order to solve this problem, an inversion algorithm for extrusion deformation estimation of oil and gas strings based on pulsed eddy ...
Xuanyong ZHOU   +5 more
doaj   +1 more source

"How Long is a Piece of String": [PDF]

open access: yesProceedings of the 2017 Workshop on Cyber-Physical Systems Security and PrivaCy, 2017
The numbers and severity of global cyber security attacks on Industrial Control Systems have increased over recent years. However, there are also significant efforts to improve defensive capabilities. While comprehensive reviews of risk assessment efforts exist, little detail is currently available on how they are being applied by security ...
Green, Benjamin   +3 more
openaire   +1 more source

Trajectories of Physical Function in Canadian Children with Juvenile Idiopathic Arthritis

open access: yesArthritis Care &Research, Accepted Article.
Objectives We describe trajectories of physical function in children newly diagnosed with juvenile idiopathic arthritis (JIA) and identify trajectories with persisting functional impairments and associated baseline characteristics. Methods We included patients enrolled in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry ...
Clare Cunningham   +14 more
wiley   +1 more source

Superstrings on AdS_3 and Symmetric Products

open access: yes, 2000
Some properties of N=2 superstrings on AdS_3 x N are studied. Their spectrum has the same pattern as 2-d CFTs in the moduli space of symmetric products M^p/S_p, where p is associated with the number of long fundamental strings required to construct the ...
Argurio, Riccardo   +2 more
core   +1 more source

Cumulative Social Disadvantage and Disease Activity in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study

open access: yesArthritis Care &Research, EarlyView.
Objective Social determinants of health (SDOH) contribute to juvenile idiopathic arthritis (JIA) disparities, but most studies have assessed SDOH independently rather than cumulatively across individual, family, and neighborhood levels. Using a socioecological framework, we investigated the relationship among cumulative social disadvantage ...
William Daniel Soulsby   +448 more
wiley   +1 more source

When strings surprise

open access: yesJournal of High Energy Physics
We argue that on-shell excitations with large negative energies are created rapidly when the string coupling increases with time. This does not indicate an inconsistency in string theory since the negative energy on-shell excitation is always entangled ...
Nissan Itzhaki, Uri Peleg
doaj   +1 more source

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