Results 1 to 10 of about 169,643 (326)

Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation [PDF]

Nature Communications
The CCKBR agonists induce neocortical long-term potentiation of excitatory synaptic transmission and enhance memory formation, while its antagonists weaken the potentiation in the amygdala and alleviate depression-like behaviors.
Heng Shi, Mengfan Zhang, Xiaofeng Hu, Jie Zhang, Tao Chen, Pingzhou Wu, Xue Wang, Shu Wei, George Choy, Stephen Temitayo Bello, Huifeng Chen, Chunhua Liu, Yiping Guo, Hongyan Sun, Jufang He   +14 more
doaj   +2 more sources

Modeling Maintenance of Long-Term Potentiation in Clustered Synapses: Long-Term Memory without Bistability [PDF]

Neural Plasticity, 2015
Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist?
Paul Smolen
doaj   +5 more sources

The roles of STP and LTP in synaptic encoding [PDF]

PeerJ, 2013
Long-term potentiation (LTP), a cellular model of learning and memory, is generally regarded as a unitary phenomenon that alters the strength of synaptic transmission by increasing the postsynaptic response to the release of a quantum of neurotransmitter.
Arturas Volianskis, Graham L. Collingridge, Morten S. Jensen   +2 more
doaj   +6 more sources

Long-Term Potentiation: The Accidental Discovery. [PDF]

Hippocampus
ABSTRACTLong‐term potentiation (LTP), is a type of synaptic plasticity now considered essential for learning and memory. Here I tell the story of how I accidentally discovered in 1966 in the laboratory of Per Andersen in Oslo, Norway, because I was not looking for it. It just emerged.
Lømo T.
europepmc   +5 more sources

Long-term potentiation and long-term depression: a clinical perspective [PDF]

Clinics, 2011
Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system.
Timothy V.P. Bliss, Sam F. Cooke
doaj   +5 more sources

Long-term potentiation in an innexin-based electrical synapse [PDF]

Scientific Reports, 2018
Electrical synapses are formed by two unrelated gap junction protein families, the primordial innexins (invertebrates) or the connexins (vertebrates). Although molecularly different, innexin- and connexin-based electrical synapses are strikingly similar ...
Georg Welzel, Stefan Schuster
doaj   +2 more sources

The Pathway-Selective Dependence of Nitric Oxide for Long-Term Potentiation in the Anterior Cingulate Cortex of Adult Mice [PDF]

Biomedicines
Nitric oxide (NO) is a key diffusible messenger in the mammalian brain. It has been proposed that NO may diffuse in retrograde into presynaptic terminals, contributing to the induction of hippocampal long-term potentiation (LTP).
Qi-Yu Chen, Jinjin Wan, Yujie Ma, Min Zhuo   +3 more
doaj   +2 more sources

The role of calcium stores in long-term potentiation and synaptic tagging and capture in mouse hippocampus. [PDF]

Philos Trans R Soc Lond B Biol Sci
Koek LA, Sanderson TM, Georgiou J, Collingridge GL.   +3 more
europepmc   +3 more sources

Long-term potentiation and neurotransmitters expression and segregation are altered in the Metabolic Syndrome-associated dysautonomia. [PDF]

PLoS One
Elinos D, Veladiz-Gracia F, González-Sierra C, Rubio-Galicia A, Cifuentes F, Morales MA.   +5 more
europepmc   +2 more sources

Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation. [PDF]

PLoS ONE, 2015
The long-term potentiation (LTP) of spinal C-fiber-evoked field potentials is considered as a fundamental mechanism of central sensitization in the spinal cord.
Chao Bian, Zhi-Qi Zhao, Yu-Qiu Zhang, Ning Lü   +3 more
doaj   +1 more source