Results 141 to 150 of about 169,643 (326)

Long-term potentiation at pyramidal cell to somatostatin interneuron synapses controls hippocampal network plasticity and memory [PDF]

, 2021
Azam Asgarihafshejani, Ève Honoré, François-Xavier Michon, Isabel Laplante, Jean‐Claude Lacaille   +4 more
openalex   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS

Вавиловский журнал генетики и селекции, 2015
Neuronal synaptic contacts are among the basic elements that determine the plasticity of the nervous system. Changes in the efficiency of synaptic transmission mediate sensation, conduction of excitation, learning, and memory.
A. L. Proskura, I. A. Malachin, T. A. Zapara, I. I. Turnaev, V. V. Suslov, A. S. Ratuschnyak   +5 more
doaj  

Impaired long-term potentiation and enhanced neuronal excitability in the amygdala of CaV1.3 knockout mice

, 2009
Brandon C. McKinney, Wilson Sze, Benjamin Lee, Geoffrey G. Murphy   +3 more
openalex   +1 more source

Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation

, 2020
Artem P. Gureev, В. Н. Попов, Anatoly A. Starkov   +2 more
openalex   +2 more sources

Gallium‐Doped MXene Nanozymes Protect Liver Through Multi‐Death Pathway Blockade and Hepatocyte Regeneration

Advanced Science, EarlyView.
This study develops gallium‐doped V2C MXene nanozymes (Ga‐V2C) to treat acetaminophen‐induced liver injury through multi‐death pathway blockade and hepatocyte regeneration. Unlike conventional single‐target therapies like N‐acetylcysteine, Ga‐V2C nanozymes enable oxidative stress suppression, apoptosis, and ferroptosis inhibition, and enhanced ...
Xiaopeng Cai, Jingwen Deng, Liqing Wang, Junjie Su, Dongyi Xian, Yilang Yan, Xinyu Yang, Chuanbin Wu, Tingting Peng, Yuan Ding, Guilan Quan, Weilin Wang, Min Zhou, Chao Lu   +13 more
wiley   +1 more source

Interactive Effects of Exercise, Sex Hormones, and Transient Congenital Hypothyroidism on Long-Term Potentiation in Hippocampal Slices of Rat Offspring

Basic and Clinical Neuroscience, 2019
Introduction: The long-term adverse effects of transient thyroid function abnormalities at birth on intellectual development are proven. The effect of exercise increases in the presence of sex hormones.
Leila Derafshpour, Ehsan Saboory, Abbas Ali Vafaei, Ali Rashidy-Pour, Shiva Roshan-Milani, Yosef Rasmi, Yosef Panahi, Hamidreza Sameni   +7 more
doaj  

A calcium-based plasticity model predicts long-term potentiation and depression in the neocortex

, 2021
Giuseppe Chindemi, Marwan Abdellah, Oren Amsalem, Ruth Benavides‐Piccione, Vincent Delattre, Michael Doron, András Ecker, Aurélien T. Jaquier, James King, Pramod Kumbhar, Caitlin Monney, Rodrigo Perin, Christian Rössert, Anil M. Tuncel, Werner Van Geit, Javier DeFelipe, Michael Graupner, Idan Segev, Henry Markram, Eilif Müller   +19 more
openalex   +2 more sources

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Current Studies on a Working Model of CaM Kinase II in Hippocampal Long-Term Potentiation and Memory

, 1999
Kohji Fukunaga, Miyamoto Eishichi
openalex   +1 more source