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Synaptic tagging and long-term potentiation
Nature, 1997Repeated stimulation of hippocampal neurons can induce an immediate and prolonged increase in synaptic strength that is called long-term potentiation (LTP)-the primary cellular model of memory in the mammalian brain. An early phase of LTP (lasting less than three hours) can be dissociated from late-phase LTP by using inhibitors of transcription and ...
Richard G. M. Morris, Uwe Frey
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2000
Virtually all notions about memory hold dear the central notion that learning relies on the modification of synaptic function. In recent years considerable attention has focused on one particular form of use-dependent synaptic plasticity known as long-term potentiation (LTP).
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Virtually all notions about memory hold dear the central notion that learning relies on the modification of synaptic function. In recent years considerable attention has focused on one particular form of use-dependent synaptic plasticity known as long-term potentiation (LTP).
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Long-Term Potentiation, Long-Term Depression, and Learning
1998Publisher Summary Almost everyone agrees that information is acquired, stored, and retrieved by the brain. All brains consist of individual cellular elements. Most neurons have the same parts: a dendritic tree, cell body, axon, and synaptic boutons.
Joe L. Martinez +2 more
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Long-term potentiation and 4-aminopyridine
Cellular and Molecular Neurobiology, 1985Long-term potentiation (LTP) of excitatory postsynaptic potentials (epsp's) was investigated with extracellular field potential recording in hippocampal slices from rats. In the presence of 100 microM 4-aminopyridine (4-AP) the probability of eliciting LTP was unchanged or increased; the extent of potentiation was not significantly different from ...
Helmut L. Haas, Robert W. Greene
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Long‐Term synaptic potentiation in the amygdala
Synapse, 1990AbstractThe manner in which the circuitry of the amygdala computes its suspected mnemonic has been a mystery, partly cellular analysis. Here we report in vitro methods and results that may help elucidate cellular learning mechanisms in amygdala neurons.
Claude L. Keenan +3 more
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NCAM in Long-Term Potentiation and Learning [PDF]
, 2009 The neural cell adhesion molecule (NCAM) is important in regulating neuronal development and plasticity by modulating cell adhesion and signal transduction. Studies using NCAM antibodies have demonstrated a role of NCAM in hippocampal long-term potentiation and in animal learning models.
Barbara P. Hartz +1 more
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Long-term potentiation and long-term depression
2006This chapter concentrates on the basic mechanisms that are thought to underlie induction and expression of long-term plasticity (LTP). LTP has been demonstrated at all of the major synapses in the hippocampus. Activity-dependent LTP is a commonly observed feature of the neocortex and does not differ from the hippocampus in its induction or expression ...
Peter V. Massey, Zafir I. Bashir
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Long-term potentiation as synaptic dialogue
Brain Research Reviews, 1993We have proposed a testable model of the physiological and biochemical events underlying LTP that offers the following novel features. (1) The focus is not on a single mechanism or synaptic site, but rather on the integration and interaction of mechanisms occurring on both sides of the synapse, (2) beta PKC plays a critical presynaptic role in LTP ...
Aryeh Routtenberg, Patricia A. Colley
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Long-Term Potentiation--A Decade of Progress?
Science, 1999Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that ...
Robert C. Malenka, Roger A. Nicoll
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Long-Term Potentiation and Drugs
1996We investigated the modulation of tetanus-induced long-term potentiation (LTP) in guinea pig hippocampal slices brought about by bath-applied drugs and by neurotransmitter-related agents, using an extracellular recording technique. The magnitude of LTP at mossy fiber-CA3 synapses was augmented by the muscarinic receptor agonist carbachol and by ...
Takehiko Maeda, Masamichi Satoh
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