Results 21 to 30 of about 805,319 (253)

LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases

Cells, 2021
Learning and memory require structural and functional modifications of synaptic connections, and synaptic deficits are believed to underlie many brain disorders.
Youssif Ben Zablah, Haiwang Zhang, Radu Gugustea, Zhengping Jia   +3 more
doaj   +1 more source

Synaptic tagging and capture in the living rat [PDF]

, 2012
In isolated hippocampal slices, decaying long-term potentiation can be stabilized and converted to late long-term potentiation lasting many hours, by prior or subsequent strong high-frequency tetanization of an independent input to a common population of
A Gasbarri, A Govindarajan, AV Sharma, CG Gross, CM Alberini, CM O'Carroll, CM O’Carroll, CR Bramham, D Moncada, DG Amaral, EL Bienenstock, F Ballarini, G Buzsaki, G Riedel, GG Turrigiano, H Hassan, I Bethus, JD Richter, JE Lisman, JL Swanson-Park, JM Alarcon, JW Rudy, JZ Young, K McNair, K Wanisch, KC Martin, KC Martin, LS Leung, M Doyle, M Hubener, MA Sutton, N Lemon, N Meiri, P Mullany, R Anwyl, R Fonseca, RD Hawkins, RL Redondo, RL Redondo, S Frey, S Laurberg, S Sajikumar, S Sajikumar, SH Wang, SI Cohen-Matsliah, SJ Martin, SM Dudek, T Kaibara, TJ O'Dell, TN Wiesel, U Frey, U Frey, U Frey, U Stäubli, WB Smith, WC Abraham, Y Lu, Z Qi   +57 more
core   +1 more source

Differential sensitivity of three forms of hippocampal synaptic potentiation to depotentiation

Molecular Brain, 2019
Theta-burst stimulation (TBS) induces short-term potentiation (STP) plus two types of transcriptionally-independent forms of long-term potentiation (LTP), termed LTP1 and LTP2.
Pojeong Park, Thomas M. Sanderson, Zuner A. Bortolotto, John Georgiou, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge   +6 more
doaj   +1 more source

Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons

Molecular Brain, 2022
Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in synaptic plasticity, learning and memory.
Miyuki Takahashi, Takeru Nakabayashi, Naoki Mita, Xiaohua Jin, Yuta Aikawa, Kodai Sasamoto, Goichi Miyoshi, Mariko Miyata, Takafumi Inoue, Toshio Ohshima   +9 more
doaj   +1 more source

Dependence receptor involvement in subtilisin-induced long-term depression and in long-term potentiation [PDF]

, 2016
The serine protease subtilisin induces a form of long-term depression (LTD) which is accompanied by a reduced expression of the axo-dendritic guidance molecule Unco-ordinated-5C (Unc-5C).
Darlington, L. Gail, Forrest, Caroline M., Stone, Trevor W.   +2 more
core   +1 more source

Pain-motor integration in the primary motor cortex in Parkinson's disease [PDF]

, 2017
In Parkinson's disease (PD), the influence of chronic pain on motor features has never been investigated. We have recently designed a technique that combines nociceptive system activation by laser stimuli and primary motor cortex (M1) activation through ...
Berardelli, Alfredo, Biasiotta, A, Cruccu, Giorgio, Di Santo, A, DI STASIO, Flavio, LA CESA, Silvia, Leone, Caterina, Marsili, Luca, Suppa, Antonio, Truini, Andrea   +9 more
core   +1 more source

Bidirectional Synaptic Plasticity Is Driven by Sex Neurosteroids Targeting Estrogen and Androgen Receptors in Hippocampal CA1 Pyramidal Neurons

Frontiers in Cellular Neuroscience, 2019
Neuroactive estrogenic and androgenic steroids influence synaptic transmission, finely modulating synaptic plasticity in several brain regions including the hippocampus.
Alessandro Tozzi, Valentina Durante, Paolo Manca, Michela Di Mauro, Juan Blasi, Silvarosa Grassi, Paolo Calabresi, Suguru Kawato, Suguru Kawato, Vito Enrico Pettorossi   +9 more
doaj   +1 more source

The roles of STP and LTP in synaptic encoding [PDF]

PeerJ, 2013
Long-term potentiation (LTP), a cellular model of learning and memory, is generally regarded as a unitary phenomenon that alters the strength of synaptic transmission by increasing the postsynaptic response to the release of a quantum of neurotransmitter.
Arturas Volianskis, Graham L. Collingridge, Morten S. Jensen   +2 more
doaj   +2 more sources

Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses [PDF]

, 2023
Presynaptic plasticity is an activity-dependent change in the neurotransmitter release and plays a key role in dynamic modulation of synaptic strength.
Fukaya, Ryota, Hirai, Himawari, Miyano, Rinako, Sakaba, Takeshi   +3 more
core   +1 more source

Tonic and phasic nitric oxide signals in hippocampal long-term potentiation [PDF]

, 2006
Nitric oxide ( NO) participates in long-term potentiation (LTP) and other forms of synaptic plasticity in many different brain areas but where it comes from and how it acts remain controversial.
Garthwaite, J, Hopper, RA
core   +1 more source