Results 61 to 70 of about 2,058,289 (307)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Linking death registration and survey data: Procedures and cohort profile for The Irish Longitudinal Study on Ageing [version 1; peer review: 2 approved, 1 approved with reservations]

HRB Open Research, 2020
Background: Research on mortality at the population level has been severely restricted by an absence of linked death registration and survey data in Ireland.
Mark Ward, Peter May, Robert Briggs, Triona McNicholas, Charles Normand, Rose Anne Kenny, Anne Nolan   +6 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A data driven approach to address missing data in the 1970 British birth cohort

BMC Medical Research Methodology
Background Missing data may induce bias when analysing longitudinal population surveys. We aimed to tackle this problem in the 1970 British Cohort Study (BCS70). Methods We utilised a data-driven approach to address missing data issues in BCS70.
Michail Katsoulis, Martina K. Narayanan, Brian Dodgeon, George B. Ploubidis, Richard J. Silverwood   +4 more
doaj   +1 more source

Harmonised Mental Health Measures at Age 10/11 in Selected British Cohorts: National Child Development Study

, 2022
copyright UK Data Service and data collection copyright owner.CLOSER (Cohort and Longitudinal Studies Enhancement Resources) aims to maximise the use, value and impact of longitudinal studies, both at home and abroad.
Cohort and Longitudinal Studies Enhancement Resources
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Trail Making Test performance contributes to subjective judgment of visual efficiency in older adults [PDF]

PeerJ, 2015
Introduction. The determinant factors that influence self-reported quality of vision have yet to be fully elucidated. This study evaluated a range of contextual information, established psychophysical tests, and in particular, a series of cognitive tests
Annalisa Setti, James Loughman, George M. Savva, RoseAnne Kenny   +3 more
doaj   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Harmonised Height, Weight and BMI in Five Longitudinal Cohort Studies: National Child Development Study

, 2019
copyright UK Data Service and data collection copyright owner.The Cohort and Longitudinal Studies Enhancement Resources (CLOSER) project aims to maximise the use, value and impact of longitudinal research. It brings together leading longitudinal studies,
Cohort and Longitudinal Studies Enhancement Resources
core   +2 more sources