Results 71 to 80 of about 46,178,416 (381)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Integrating public engagement to promote transparent data use in a new UK-wide birth cohort

International Journal of Population Data Science
Public engagement is an important mechanism for ensuring that the voices of the public are integrated into study design and data use. The commissioning of a new UK-wide birth cohort study by the UKRI Economic and Social Research Council (ESRC), the ...
Alyce Raybould, Karen Dennison, Orla McBride, Erica Wong, Lisa Calderwood, Pasco Fearon, Alissa Goodman   +6 more
doaj   +1 more source

The UK Coronavirus Job Retention Scheme and smoking, alcohol consumption and vaping during the COVID-19 pandemic: evidence from eight longitudinal population surveys

BMC Medicine, 2022
Background Employment disruptions can impact smoking and alcohol consumption. During the COVID-19 pandemic, many countries implemented furlough schemes to prevent job loss.
Michael J. Green, Jane Maddock, Giorgio Di Gessa, Bożena Wielgoszewska, Sam Parsons, Gareth J. Griffith, Jazz Croft, Anna J. Stevenson, Charlotte F. Huggins, Charlotte Booth, Jacques Wels, Richard J. Silverwood, Praveetha Patalay, Alun D. Hughes, Nishi Chaturvedi, Laura D. Howe, Emla Fitzsimons, Srinivasa Vittal Katikireddi, George B. Ploubidis   +18 more
doaj   +1 more source

Osteoporotic and Neoplastic Compression Fracture Classification on Longitudinal CT

, 2016
Classification of vertebral compression fractures (VCF) having osteoporotic or neoplastic origin is fundamental to the planning of treatment. We developed a fracture classification system by acquiring quantitative morphologic and bone density ...
Burns, Joseph E., Summers, Ronald M., Wang, Yinong, Yao, Jianhua   +3 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Structure and correlates of cognitive aging in a narrow age cohort [PDF]

, 2014
Aging-related changes occur for multiple domains of cognitive functioning. An accumulating body of research indicates that, rather than representing statistically independent phenomena, aging-related cognitive changes are moderately to strongly ...
Briley, Daniel A, Deary, Ian J, Starr, John M, Tucker-Drob, Elliot M   +3 more
core   +1 more source

Risk factors and protective factors associated with incident or increase of frailty among community-dwelling older adults: A systematic review of longitudinal studies

PLoS ONE, 2017
Introduction Frailty is one of the greatest challenges facing our aging population, as it can lead to adverse outcomes such as institutionalization, hospitalization, and mortality.
Zeyun Feng, M. Lugtenberg, C. Franse, Xinye Fang, Shanlian Hu, C. Jin, H. Raat   +6 more
semanticscholar   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Mycotoxin exposure and human cancer risk : a systematic review of epidemiological studies

, 2020
In recent years, there has been an increasing interest in investigating the carcinogenicity of mycotoxins in humans. This systematic review aims to provide an overview of data linking exposure to different mycotoxins with human cancer risk. Publications (
Castegnaro M., De Ruyck K., Eaton D. L., European Food Safety Authority (EFSA), Forner A., Halabi K., Huang C., Huang X., IARC, IARC, Knutsen H. K., Knutsen H. K., Peraica M., Ramljak D., Steinkellner H., Stephany R. W., The Commission of the European Communities   +16 more
core   +2 more sources

A comparison of multiple imputation methods for missing data in longitudinal studies

BMC Medical Research Methodology, 2018
BackgroundMultiple imputation (MI) is now widely used to handle missing data in longitudinal studies. Several MI techniques have been proposed to impute incomplete longitudinal covariates, including standard fully conditional specification (FCS-Standard)
Md Hamidul Huque, J. Carlin, J. Simpson, Katherine J. Lee   +3 more
semanticscholar   +1 more source