Results 151 to 160 of about 35,344 (268)

Loop-mediated Isothermal Amplification [PDF]

, 2020
openaire   +1 more source

ElectrochemCap: an integrated detection for loop-mediated isothermal amplification reactions

Lab on a Chip
An electrochemical microcentrifuge tube cap (ElectrochemCap) for integrated (bio)electroanalysis is demonstrated with a LAMP amplification reaction and its subsequent electrochemical detection. Adaptations for different containers are also presented.
P. Rioboó-Legaspi, E. Costa-Rama, M. T. Fernández-Abedul   +2 more
openaire   +4 more sources

Mesoscale and Submesoscale Variability in the Indian Ocean

Reviews of Geophysics, Volume 64, Issue 2, June 2026.
Abstract Material transport and air‐sea coupling dynamics associated with monsoon‐related mesoscale and submesoscale processes in the Indian Ocean significantly modulate biogeochemical cycles, the large‐scale energy balance, and both regional and global climate change.
Lei Zhou, Dongxiao Wang, Xuhua Cheng, Lixin Qu, Yun Qiu, Fuan Xiao, Lin Wang, Qiaoyan Wu, Xiaoyi Yang, Zhigang Lai, Danian Liu, Hui Zhao, Lin Liu, Ke Huang, Jianhuang Qin, Baosheng Li, Guangli Zhang, Chunhua Qiu, Haibo Tang, Huaming Huang   +19 more
wiley   +1 more source

Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 5, Page 1019-1029, May 2026.
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall, Henry G. Box, Karl A. P. Payne, Stephen A. Marshall, David Leys   +4 more
wiley   +1 more source

Advances in Avian Diagnostic Pathology: Current Trends, Challenges and Future Directions: A Review

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Advances in avian diagnostic pathology integrate histopathology, immunohistochemistry, molecular diagnostics and digital pathology to enhance the detection and management of poultry diseases. Emerging tools, including machine learning and artificial intelligence, further improve diagnostic accuracy, disease surveillance and outbreak prediction.
Gebyaw Menge Getnet, Mengesha Ayehu Getnet, Ayenalem Shibabaw Atenaf   +2 more
wiley   +1 more source

Mechanistic Basis of Cholesterol Binding and Transfer in NPC2: Insights From Molecular Dynamics Simulations

ChemBioChem, Volume 27, Issue 7, 14 April 2026.
A mechanistic basis is proposed for how variation in protein sequence perturbs cholesterol handling in Niemann–Pick type C2 (NPC2) protein. A relatively rigid hydrophobic core stabilizes cholesterol binding, a flexible but coordinated rim enables controlled access and productive transfer of cholesterol, and coordinated loop motions modulate pocket ...
Smit Patel, Nadia Elghobashi‐Meinhardt
wiley   +1 more source

The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia, Michael Kapsalis, Michael Georgoulakis, Athanasios Panousis, Constantinos G. Neochoritis   +4 more
wiley   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, Volume 13, Issue 19, 2 April 2026.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Interfacial Engineering in Rare‐Earth Oxide/ZnO Heterojunctions for High‐Performance Trimethylamine Sensing and Fish Freshness Monitoring

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study realizes superior gas sensing performance via Yb2O3/ZnO heterojunction design, achieving highly sensitive/selective trimethylamine detection at room temperature while elucidating the intrinsic sensing mechanism. This innovation is applied to reliable real‐time fish freshness monitoring, paving a feasible way for translating advanced material
Junxi Cheng, Chang Liu, Miaomiao Liu, Qihua Sun, Jun Sun, Zhaofeng Wu   +5 more
wiley   +1 more source

Rational Design Strategies for Stimuli‐Responsive DNAzymes Using Modified and Artificial Nucleotides

Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.
Activity control of RNA‐cleaving DNAzymes in response to external stimuli has attracted growing interest for applications in DNA‐based diagnostics, therapeutics, and dynamic DNA nanotechnology. This review summarizes rational design strategies for stimuli‐responsive DNAzymes using modified or artificial nucleotides, including split and caged DNAzymes ...
Yusuke Takezawa, Mitsuhiko Shionoya
wiley   +1 more source