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Bumetanide, a new loop diuretic
Clinical Pharmacology & Therapeutics, 1976The effect of bumetanide on renal function has been compared with that o.ffurosemide and a placebo in a double‐blind study in 9 healthy young men. The sequence for oral administration of the drug was subjected to a random assignation based upon the Latin‐square methodology under three different conditions.
S. Carrière +4 more
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Effects of Ototoxic Diuretics (Loop Diuretics) on the Endolymphatic Sac
ORL, 2010The acute and chronic effects of treatment with ethacrynic acid (EA) and furosemide (FU) on the structure of the murine endolymphatic sac were studied by means of light and transmission electron microscopy. The animals were treated with loop diuretics in doses which are known to cause morphological alterations of the stria vascularis and a significant ...
C, Erwall +3 more
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Loop diuretics in heart failure
Heart Failure Reviews, 2011Congestion is a major component of the clinical syndrome of heart failure, and diuretic therapy remains the cornerstone of congestion management. Despite being widely used, there is very limited evidence from prospective randomized studies to guide the prescription and titration of diuretics.
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Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics [PDF]
Current Heart Failure ReportsPurpose of Review: Fluid retention or congestion is a major cause of symptoms, poor quality of life, and adverse outcome in patients with heart failure (HF).
Andrew L Clark, Joseph J Cuthbert
exaly +2 more sources
Clinical Pharmacology of Loop Diuretics
Drugs, 1991The clinical pharmacology of torasemide, bumetanide, piretanide and furosemide (frusemide) is discussed. These drugs share a similar mechanism of action in inhibiting Na(+)-K(+)-2Cl- reabsorption at the thick ascending limb of the loop of Henle. They differ in their routes of metabolism, pharmacokinetics, and potency.
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[Loop diuretics and ototoxicity].
Actas urologicas espanolas, 2008Loop diuretics are quite often used in medical practice. In spite of a wide security, there are several adverse events that should be known, in order to be early recognised as soon as they appear. Ototoxicity associated to furosemide is infrequent and reversible.
R, Martínez-Rodríguez +5 more
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