Results 41 to 50 of about 9,816 (262)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The one-loop functional of chiral SU(2) [PDF]

Journal of High Energy Physics, 2002
The one-loop functional for chiral SU(2) of Gasser and Leutwyler is extended to include up to three propagators. With this generating functional it is possible to calculated all amplitudes up to order phi^6 to next-to-leading order in the low-energy expansion. An external pion is of order phi and a vector gauge boson is of order phi^2.
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Stabilization of Neutral Time-Delay Systems With Actuator Saturation via a Sampled-Data Control Approach

IEEE Access
This paper considers the stabilization problem for neutral time-delay systems with actuator saturation under a sampled-data controller. For the actuator saturation, the saturation nonlinearity is represented as the convex combination of the state ...
Seok Young Lee, Junmin Park
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Stabilization of chaotic quaternion-valued neutral-type neural networks via sampled-data control with two-sided looped functional approach

Nonlinear Analysis
The quaternion-valued neutral-type neural networks (QVNTNNs) stability problem through designing sampled-data controller is investigated in this paper. A main stability criterion of the considered neural networks (NNs) is obtained in the form of linear ...
Qiankun Song, Qian Wu, Yurong Liu
doaj   +1 more source

No Vertical Scar Breast Weight Transfer

Plastic and Reconstructive Surgery, Global Open, 2017
Summary:. Women desire beautiful breasts that are functional, pain free, and without foreign material. Vertical scars, insufficient elevation, inadequate upper pole fullness, nipple numbness, and loss of breast feeding are undesirable.
Gary M. Horndeski, MD, Elisa Gonzalez, PA-C   +1 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

R-loop functions in Brca1 -associated mammary tumorigenesis

Proceedings of the National Academy of Sciences
Deleterious accumulation of R-loops, a DNA–RNA hybrid structure, contributes to genome instability. They are associated with BRCA1 mutation-related breast cancer, an estrogen receptor α negative (ERα − ) tumor type originating from luminal progenitor cells.
Huai-Chin Chiang, Leilei Qi, Payal Mitra, Yimeng Huang, Yanfen Hu, Rong Li   +5 more
openaire   +4 more sources

Sampled-Data Exponential Synchronization of Complex Dynamical Networks with Saturating Actuators

Entropy
This paper investigates the problem of exponential synchronization control for complex dynamical systems (CDNs) with input saturation. Considering the effects of transmission delay, a memory sampled-data controller is designed.
Runan Guo, Wenshun Lv
doaj   +1 more source