Results 41 to 50 of about 9,881 (262)

Circular RNA as a Potential Biomarker for Melanoma: A Systematic Review

Frontiers in Cell and Developmental Biology, 2021
Circular RNAs (circRNAs) are newly discovered RNAs with covalently looped structures. Due to their resistance to RNAase degradation and tissue-specific expression, circRNAs are expected to be potential biomarkers in early diagnosis and target treatment ...
Keyun Tang, Hanlin Zhang, Yaqi Li, Qiuning Sun, Hongzhong Jin   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The one-loop functional of chiral SU(2) [PDF]

Journal of High Energy Physics, 2002
The one-loop functional for chiral SU(2) of Gasser and Leutwyler is extended to include up to three propagators. With this generating functional it is possible to calculated all amplitudes up to order phi^6 to next-to-leading order in the low-energy expansion. An external pion is of order phi and a vector gauge boson is of order phi^2.
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Stabilization of Neutral Time-Delay Systems With Actuator Saturation via a Sampled-Data Control Approach

IEEE Access
This paper considers the stabilization problem for neutral time-delay systems with actuator saturation under a sampled-data controller. For the actuator saturation, the saturation nonlinearity is represented as the convex combination of the state ...
Seok Young Lee, Junmin Park
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Sampled-Data Exponential Synchronization of Complex Dynamical Networks with Saturating Actuators

Entropy
This paper investigates the problem of exponential synchronization control for complex dynamical systems (CDNs) with input saturation. Considering the effects of transmission delay, a memory sampled-data controller is designed.
Runan Guo, Wenshun Lv
doaj   +1 more source

Reflexive transitive invariant relations: A basis for computing loop functions

Journal of Symbolic Computation, 2010
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ali Mili 0001, Shir Aharon, Chaitanya Nadkarni, Lamia Labed Jilani, Asma Louhichi, Olfa Mraihi   +5 more
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source