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Loratadine, 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester, is an antihistamine drug with long-acting effects and has limited selectivity for peripheral H1 receptors. It is widely used for the prevention of allergic diseases such as rhinitis chronic urticaria, and asthma.
Najla, AlMasoud +4 more
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Loratadine, 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester, is an antihistamine drug with long-acting effects and has limited selectivity for peripheral H1 receptors. It is widely used for the prevention of allergic diseases such as rhinitis chronic urticaria, and asthma.
Najla, AlMasoud +4 more
openaire +3 more sources
The American Journal of Emergency Medicine, 2000
WOS ...
Gokel, Y, Satar, S, Sebe, A
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Gokel, Y, Satar, S, Sebe, A
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Cardiovascular profile of loratadine
Clinical & Experimental Allergy, 1999The extremely low reporting rate of cardiovascular adverse events for loratadine, the possible preferential use of loratadine in patients with pre‐existing cardiovascular disorders, and the impressive lack of cardiovascular effects at extremely high concentrations in clinical and preclinical studies demonstrate the very safe cardiovascular profile of ...
J A, Hey +4 more
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Loratadine in the treatment of urticaria
Clinical Therapeutics, 1997Urticaria is a common skin disease, which in its chronic form, is a very disturbing condition. Because histamine is the best-documented chemical mediator of urticaria, histamine-antagonists are the mainstay of therapy. First-generation antihistamines are limited by their tendency to produce sedation and anticholinergic side effects.
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Pharmacokinetics and Dose Proportionality of Loratadine
The Journal of Clinical Pharmacology, 1987The dose proportionality and pharmacokinetics of loratadine, a new nonsedating antihistamine, were studied in 12 normal volunteers. In a three‐way cross‐over, each volunteer received a single 10‐, 20‐, or 40‐mg loratadine capsule. Blood was collected up to 96 hours after dosing. Plasma loratadine concentrations were determined by radioimmunoassay (RIA),
J, Hilbert +6 more
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