Results 111 to 120 of about 73,633 (314)

Cardiovascular risk reduction in hypertensive black patients with left ventricular hypertrophy The life study [PDF]

, 2004
ObjectivesWe report on a subanalysis of the effects of losartan and atenolol on cardiovascular events in black patients in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study.BackgroundThe LIFE study compared losartan-based to ...
Alderman, Michael H, Beevers, Gareth, Dahlöf, Björn, Devereux, Richard B, Douglas, Janice G, Edelman, Jonathan M, Harris, Katherine E, Julius, Stevo, Kjeldsen, Sverre E, Nesbitt, Shawna, Randall, Otelio S, Wright, Jackson T   +11 more
core   +1 more source

Advancing antihypertensive drug development

British Journal of Pharmacology, Volume 182, Issue 15, Page 3389-3410, August 2025.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu, Yanrong Liu, Fozia Zahir Ahmed, Xin Wang, Darren Green, Hongyuan Zhang   +5 more
wiley   +1 more source

MODERN POSSIBILITIES OF ACHIEVING TARGET BLOOD PRESSURE LEVEL IN HYPERTENSIVE PATIENTS IN OUTPATIENT PRACTICE: THE LEADER STUDY RESULTS

Рациональная фармакотерапия в кардиологии, 2018
Aim. To study the efficacy and safety of the use of hydrochlorothiazide/losartan or amlodipine/losartan fixed combinations in patients with arterial hypertension (HT) in real clinical practice.Material and methods.
D. V. Nebieridze, A. S. Safaryan, V. A. Vygodin, O. M. Drapkina, S. A. Boytsov   +4 more
doaj   +1 more source

Concordance of gout management with European League against Rheumatism recommendations in hospital practice [PDF]

, 2010
Aim: To assess the concordance of gout management with the European League Against Rheumatism (EULAR) gout recommendations in hospital practice. Methods: This was a retrospective review of case notes of patients presenting to rheumatology outpatients ...
Attard Cortis, Petramay, Borg, Andrew A., Coleiro, Bernard, Mercieca, Cecilia   +3 more
core  

TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults. [PDF]

, 2017
Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often leads to the development of epilepsy. Patients who develop post-injury epilepsy tend to have poor functional outcomes.
Becker, Albert, Friedman, Alon, Gu, Feng, Heinemann, Uwe, KAUFER, daniela, Kim, Soo, Lippmann, Kristina, Milikovsky, Dan, Morrissey, Christapher, Parada, Isabel, Prince, David, Senatorov, Vladimir, Vazquez, Oscar   +12 more
core   +1 more source

A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials [PDF]

, 2017
There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease.
Agresti, C., Buscarinu, Maria Chiara, Calo', Giorgia, Eleuteri, Cecilia, Ferrari, F., Mechelli, Rosella, Olla, S., Ristori, Giovanni, Romano, Silvia, Salvetti, Marco, Umeton, Renato, Veroni, Chiara   +11 more
core   +2 more sources

A randomised controlled trial of losartan as an anti-fibrotic agent in non-alcoholic steatohepatitis

PLoS ONE, 2017
Introduction Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide. Experimental and small clinical trials have demonstrated that angiotensin II blockers (ARB) may be anti-fibrotic in the liver.
S. McPherson, Nina Wilkinson, D. Tiniakos, J. Wilkinson, A. Burt, E. McColl, D. Stocken, N. Steen, J. Barnes, Nicola Goudie, S. Stewart, Y. Bury, D. Mann, Q. Anstee, C. Day   +14 more
semanticscholar   +1 more source

The effects of single and combined application of ramipril and losartan on renal structure and function in hypertensive rats

Clinical and Experimental Hypertension, 2018
The objective of the present study was to investigate the effects of single and combined administration of ramipril and losartan on renal structure and function in spontaneously hypertensive rats (SHRs). Thirty-two 9-week-old SHRs and eight Wistar-Kyoto (
Lin Yun, Xingshun Xu, Ying Dai, Rui Xu, Guohua Li, Yucai Yao, Jiamin Li, Fei Zheng   +7 more
doaj   +1 more source

Losartan therapy and hyperuricemia correction in patients with metabolic syndrome and arterial hypertension

Кардиоваскулярная терапия и профилактика, 2011
Aim. To assess the potential of the angiotensin II receptor antagonist losartan for the correction of hyperuricemia (HU) in patients with arterial hypertension (AH) and metabolic syndrome (MS). Material and methods.
S. V. Nedogoda, E. V. Chumachok, A. A. Ledyaeva, V. V. Tsoma   +3 more
doaj   +1 more source

Investigation of a broad‐spectrum micronutrient formulation as a possible precipitant of pharmacokinetic micronutrient–drug interactions

British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 1987-1995, July 2025.
Aims Daily broad‐spectrum micronutrients are being used by the general public and formulations are receiving research interest in mental health settings. Despite concerns about combining medicines and broad‐spectrum micronutrients in mental health care, there have not been any formal evaluations of potential interactions.
Bess M. Kew, Matthew P. Doogue, Richard McNeill, Mei Zhang, Julia J. Rucklidge, Christopher M. Frampton, Roger T. Mulder, Ben Beaglehole   +7 more
wiley   +1 more source