Results 71 to 80 of about 58,845 (265)
Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats [PDF]
, 2015 Hypertension-induced structural remodeling of the left atrium (LA) has been suggested to involve the renin–angiotensin system. This study investigated whether treatment with an angiotensin receptor blocker, candesartan, regresses atrial remodeling in ...
Choisy, Stéphanie C. +5 more
core +1 more source
Considerations for drug trials in hypertrophic cardiomyopathy
ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant +17 more
wiley +1 more source
, 2004 Hypertension is a rapidly moving clinical field with frequent developments in new pharmacologic agents and management strategies. Perhaps more importantly, there have been substantial improvements in our understanding of how best to use the drugs ...
Farrugia, Emanuel
core
Generic versus brand-name drugs used in cardiovascular diseases [PDF]
, 2016 This meta-analysis aimed to compare the efficacy and adverse events, either serious or mild/moderate, of all generic versus brand-name cardiovascular medicines.
Boccia, Stefania +9 more
core +1 more source
Sustainability in Analytical Chemistry Illustrated by Pharmaceutical Nitrosamine Testing
ELECTROPHORESIS, EarlyView.ABSTRACT Following the valsartan scandal in 2018, the testing of drug substances and drug products for N‐nitrosamines has become a critical and mandatory quality control measure. The European Pharmacopoeia chapter 2.5.42 currently describes three analytical methods for this purpose: HPLC–MS/MS, GC–MS, and GC–MS/MS.
Felix Bredendiek +2 more
wiley +1 more source
PLoS ONE, 2015 Inhibition of angiotensin II type 1 receptor (AT1R) is an important therapy in the management of hypertension, particularly in the immediate post-myocardial infarction period.
Minwoo A Song +2 more
doaj +1 more source
Expert Approaches to the Assessment of Losartan Drugs Bioequivalence
Регуляторные исследования и экспертиза лекарственных средств, 2020 Angiotensin II receptor antagonists (ARAs) are one of the most promising classes of antihypertensive drugs. They are most widely represented on the Russian market by losartan drugs which total 24 items.
D. P. Romodanovsky, D. V. Goryachev
doaj +1 more source
Advanced Science, 2022 Pancreatic ductal adenocarcinoma (PDAC), one of the worst prognosis types of tumors, is characterized by dense extracellular matrix, which compresses tumor vessels and forms a physical barrier to inhibit therapeutic drug penetration and efficacy. Herein,
Suchen Bian +12 more
doaj +1 more source
Cardiovascular morbidity following epilepsy: A nationwide retrospective cohort study in South Korea
Epilepsia Open, EarlyView.Abstract Objective This study evaluated the long‐term risk of major cardiovascular diseases (CVDs) in patients with epilepsy using a nationwide cohort, aiming to address critical gaps in population‐based evidence on brain–heart interactions. Methods Data from the Korean National Health Insurance Service (2002–2013) were analyzed.
Youngoh Bae +5 more
wiley +1 more source