Results 81 to 90 of about 42,220 (210)

A Retrospective Analysis of Human Angiotensin II Receptor Blockers (ARB) Pharmacokinetics, Dosages and Cmax Values for the Experimental Modelling of Pleiotropic and Supratherapeutic Activities

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Angiotensin II (AngII) receptor blockers (ARBs) are medications that lower systolic blood pressure (BP) by antagonizing the AngII type 1 receptor (AT1). However, ARBs have documented or suspected therapeutic properties in diseases not caused by high BP including diabetes, muscular dystrophy, chronic obstructive pulmonary diseases (COPD) and ...
Alexandria Evans, Pascal Bernatchez
wiley   +1 more source

Network medicine and systems pharmacology approaches to predicting adverse drug effects

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 8, Page 1627-1639, April 2026.
Identifying and understanding the relationships between drug intake and adverse effects that can occur due to inadvertent molecular interactions between drugs and targets is a difficult task, especially considering the numerous variables that can influence the onset of such events.
Alessio Funari   +2 more
wiley   +1 more source

Losartan for Preventing Aortic Root Dilatation in Patients with Marfan Syndrome: A Meta-Analysis of Randomized Trials

open access: yesCardiology and Therapy, 2019
Introduction The role of losartan in preventing aortic root dilatation in Marfan syndrome has been evaluated in many clinical trials; however, the results are conflicting.
Ayman Elbadawi   +12 more
doaj   +1 more source

Cryptococcid Sweet Syndrome in the Setting of Hydralazine‐Induced ANCA Vasculitis: A Case Report

open access: yesJournal of Cutaneous Pathology, Volume 53, Issue 4, Page 356-361, April 2026.
ABSTRACT Acute febrile neutrophilic dermatosis, also known as Sweet syndrome, is an inflammatory skin condition characterized by the rapid onset of painful, erythematous plaques or nodules with neutrophilic infiltrate on histology. Rarely, acellular bodies surrounded by vacuolated spaces have been noted within the neutrophilic infiltrate, mimicking ...
Jenna Vroman   +4 more
wiley   +1 more source

The effects of single and combined application of ramipril and losartan on renal structure and function in hypertensive rats

open access: yesClinical and Experimental Hypertension, 2018
The objective of the present study was to investigate the effects of single and combined administration of ramipril and losartan on renal structure and function in spontaneously hypertensive rats (SHRs). Thirty-two 9-week-old SHRs and eight Wistar-Kyoto (
Lin Yun   +7 more
doaj   +1 more source

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

open access: yesAdvanced Science, Volume 13, Issue 14, 9 March 2026.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan   +17 more
wiley   +1 more source

Influence of losartan on the hypoglycemic activity of glimepiride in normal and diabetic rats

open access: yesTherapeutic Advances in Endocrinology and Metabolism, 2013
Background: The influence of losartan on the hypoglycemic effect of glimepiride was studied in normal and diabetic rats. Method: Losartan and glimepiride were studied at a dose of 4.5 and 0.09 mg/kg and in normal and diabetic rats, respectively.
T.E.G.K. Murthy   +2 more
doaj   +1 more source

Vaginal Ulcers Secondary to Stage Iv Uterine Prolapse Treated With L‐PRF

open access: yesClinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Pelvic organs prolapse (POP) is usually used to describe the pelvic organs' descent into or through the vagina. The related common complications are bleeding, extrusion, vaginal discharge, pain, and constipation; only older women and those with comorbidities seem to be most prone to persist with their use.
Alberta Greco Lucchina   +4 more
wiley   +1 more source

Angiotensin IV Receptors Mediate the Cognitive and Cerebrovascular Benefits of Losartan in a Mouse Model of Alzheimer's Disease

open access: yesJournal of Neuroscience, 2017
The use of angiotensin receptor blockers (ARBs) correlates with reduced onset and progression of Alzheimer's disease (AD). The mechanism depicting how ARBs such as losartan restore cerebrovascular and cognitive deficits in AD is unknown. Here, we propose
Jessika Royea   +3 more
semanticscholar   +1 more source

A Case of Intermittent Fever a Decade After Renal Transplantation

open access: yesClinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Disseminated histoplasmosis is a potentially serious complication after organ transplantation; however, its occurrence is rare, even in endemic regions. Diagnosis can be challenging, particularly in patients with nonspecific symptoms such as intermittent fever or lethargy.
Merazul Islam Ony   +2 more
wiley   +1 more source

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