Results 91 to 100 of about 114,870 (312)

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Inducing Private Wildfire Risk Mitigation: Experimental Investigation of Measures on Adjacent Public Lands [PDF]

open access: yes
Increasing private wildfire risk mitigation is an important part of the larger forest restoration policy challenge. Data from an economic experiment are used to evaluate the effectiveness of providing fuel treatments on public land adjacent to private ...
Joseph M. Little   +4 more
core  

Does Mitigation Save? Reviewing cost-1 benefit analyses of disaster risk reduction [PDF]

open access: yes, 2014
The benefit-cost-ratio (BCR), used in cost-benefit analysis (CBA), is an indicator that attempts to summarize the overall value for money of a project.
Shreve, Cheney   +8 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Enhancing capacities for disaster mitigation and reconstruction in the built environment: a case study from Sri Lanka [PDF]

open access: yes
Throughout the recent decades, natural and man-made disasters have demonstrated the fragility of the built environment and its vulnerability to hazards.
Ginige, K. N.   +2 more
core  

Freshwater Wetlands Compensatory Mitigation: Is No-Net-Loss a Reality? [PDF]

open access: yes, 1998
This review was conducted to determine the success of compensatory mitigation in freshwater wetland permitting programs throughout the United States, which affects the net gain or loss of wetland habitat in this country.
Suggs, Sarah
core  

Risk-Based Wind Loss and Mitigation for Residential Wood Framed Construction [PDF]

open access: yes, 2015
As a result of increasing windstorm losses in the United States over the past 50 years, a variety of residential wind hazard mitigation methods have been suggested.
Orooji, Fatemeh
core   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The Complementary Roles of Mitigation and Insurance in Managing Catastrophic Risks [PDF]

open access: yes
This paper examines the impact that specific risk mitigation measures (RMMs) could have on reducing losses from hurricanes and earthquakes as well as improving the solvency position of insurers who provide coverage against these hazards. We first explore
Paul Kleindorfer, Howard Kunreuther
core  

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